Combined medicine for treating acne and preparation method thereof

A medicine and a technology for acne are applied in the field of combination medicine for treating acne and its preparation, which can solve the problems of unclear pharmacological action mechanism and low strength, and achieve the effects of avoiding acne recurrence, improving membrane permeability and improving efficiency.

Inactive Publication Date: 2018-07-24
覃静欣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing literature, there are extensive reports on the pharmacological effects of mangiferin, including: relieving asthma, relieving cough, reducing phlegm, lowering blood sugar, antibacterial, anti-inflammatory, anti-lipid peroxidation, protecting liver and gallbladder, immune regulation, anti-allergic , anti-inflammatory, analgesic, anti-viral, central nervous system excitatory, cardiotonic, analgesic, antipyretic, anti-tumor, etc., but the intensity of each action is not outstanding, and the mechanism of pharmacological action is not clear

Method used

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  • Combined medicine for treating acne and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of orange peel extract

[0036] (1) Take the dried orange peel and put it in a high-speed pulverizer to pulverize it evenly, add 8mL / g orange peel powder with a concentration of 95% ethanol, keep it warm at 60°C for 2h, cool it to room temperature and carry out suction filtration, and put the filtrate in Vacuum concentration at 50°C to recover ethanol, repeated washing with petroleum ether, centrifugal separation, and vacuum concentration to completely remove ethanol to obtain orange peel extract;

[0037] Preparation of Esterified Mangiferin

[0038] (2) Add 1.5% by volume of 98% H 2 SO 4 After dripping, add 1g / 10mL mangiferin of acetic anhydride, mix well to form a suspension; put this suspension in a 40°C electric heating constant temperature water bath, keep this temperature for 18h, and stir from time to time during the period to make the mangiferin All dissolved; after the reaction was completed, the reaction solution was directly poured into 10L of...

Embodiment 2

[0046] Preparation of orange peel extract

[0047] (1) Take the dried orange peel and put it in a high-speed pulverizer to pulverize it evenly, add 15mL / g orange peel powder with a concentration of 95% ethanol, keep it warm at 60°C for 4h, cool it to room temperature and carry out suction filtration, and put the filtrate in Vacuum concentration at 50°C to recover ethanol, repeated washing with petroleum ether, centrifugal separation, and vacuum concentration to completely remove ethanol to obtain orange peel extract;

[0048] Preparation of Esterified Mangiferin

[0049] (2) Add 2.5% by volume of 98% H 2 SO 4 After dripping, add 5g / 10mL mangiferin of acetic anhydride, mix well to form a suspension; put this suspension in a 40°C electric heating constant temperature water bath, keep this temperature for 18h, and stir from time to time during the period to make the mangiferin All dissolved; after the reaction was completed, the reaction solution was directly poured into 10L o...

Embodiment 3

[0057] Preparation of orange peel extract

[0058] (1) Take the dried orange peel and put it in a high-speed pulverizer to pulverize it evenly, add 10mL / g orange peel powder with a concentration of 95% ethanol, keep it warm at 60°C for 3h, cool it to room temperature and carry out suction filtration, and put the filtrate in Vacuum concentration at 50°C to recover ethanol, repeated washing with petroleum ether, centrifugal separation, and vacuum concentration to completely remove ethanol to obtain orange peel extract;

[0059] Preparation of Esterified Mangiferin

[0060] (2) In a water bath at room temperature and under constant stirring, add 2% by volume of 98% H 2 SO 4 After dripping, add 4g / 10mL mangiferin of acetic anhydride, mix well to form a suspension; put this suspension in a 40°C electric heating constant temperature water bath, keep this temperature for 18h, stir from time to time during the period to make the mangiferin All dissolved; after the reaction was comp...

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Abstract

The invention discloses a combined medicine for treating acne and a preparation method thereof. The combined medicine provided by the invention is prepared from esterified mangiferin, sodium houttuyfonate, berberine hydrochloride, folium artemisiae argyi essential oil, a pericarpium citri extract, a Guangxi folium rubi suavissimi extract and succinic acid, and is prepared by microencapsulating themain components mangiferin and berberine; the combined medicine provided by the invention is lasting in drug effect, has a quite strong inhibitory effect on the propionibacterium acnes, is used for dredging a pilosebaceous catheter to promote the removal of the acne, and meanwhile, is used for keeping the skin moist, promoting the skin to absorb the essence of the medicine and preventing the acnefrom recrudescence, and the combined medicine provided by the invention also has anti-inflammatory and antiallergic functions, and the like, and is a medicine for treating the acne, which is mild inmedicinal property and quick in curative effect.

Description

technical field [0001] The invention belongs to the technical field of preparation of skin care products, and in particular relates to a combination medicine for treating acne and a preparation method thereof. Background technique [0002] Acne, or acne, is one of the most common skin diseases in adolescent men and women. It mainly occurs in areas with dense sebaceous glands and strong sebum secretion such as the face, chest and upper back. The clinical manifestations are whiteheads, blackheads and inflammatory papules. , severe pustules, nodules and cysts may occur, and some people will also leave scars and pigmentation after being cured. Therefore, it is not only a skin trouble, but also has adverse effects on patients socially, psychologically and emotionally. [0003] Propionibacterium acnes is the main pathogenic bacteria. At present, antibiotics and retinoic acid treatment are the main methods to treat acne caused by P. acnes. However, due to the emergence of bacteria...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P17/10A61K8/9789A61K8/60A61K8/46A61K8/49A61K8/362A61K8/11A61Q19/00A61Q17/00A61K31/4375A61K31/352A61K31/194A61K31/185
CPCA61K36/752A61K8/11A61K8/362A61K8/463A61K8/49A61K8/602A61K8/97A61K31/185A61K31/194A61K31/352A61K31/4375A61K36/282A61K36/73A61K2236/333A61K2236/51A61K2236/53A61K2800/56A61K2800/592A61Q17/005A61Q19/00A61K2300/00
Inventor 覃静欣
Owner 覃静欣
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