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Aspiration device

A slender component, remote technology, applied in vaccination ovulation diagnosis, medical science, diagnosis, etc., can solve the problems of increasing cost and missing the main diagnosis

Pending Publication Date: 2019-07-19
YALE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

7.7% required re-biopsy and 4% missed primary diagnosis
It also increases the cost for hospitals to provide procedural sedation to treat pain

Method used

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experiment example

[0137] The present invention is described in further detail by referring to the following Experimental Examples. These examples are provided for the purpose of illustration only and are not limiting unless otherwise stated. Accordingly, the invention should in no way be construed as limited to the following examples, but rather should be understood to encompass any and all variations which become apparent as a result of the teaching presented herein.

[0138] Without further description, it is believed that one of ordinary skill in the art can, using the foregoing description and the following illustrative examples, make and utilize the compounds of the invention and perform the claimed methods. Accordingly, the following working examples specifically point out exemplary embodiments of the present invention and should not be construed as limiting in any way the remainder of the disclosure.

Embodiment 1

[0139] Example 1: Intraosseous method for drug mobilization of stem cells

[0140] In a typical bone marrow aspiration (BMA) procedure, when collecting stem cells near the puncture port, venous blood inevitably flows from the sinusoid, contaminating the sample and limiting the collected stem cells. Slowly injecting the drug into the bone is able to spread throughout the bone because it is a large interconnected space of veins, much like a sponge. An infusion that is too fast simply pushes the drug into the venous system rather than the bone. By first pharmacologically flooding the venous space of the bone, sinusoidal blood can be used to harvest stem cells away from the puncture site, greatly increasing yield beyond the configuration of existing devices. Subcutaneous and intravenous pharmacological approaches are too persistent for the intra-procedural acquisitions required for regenerative medicine and cancer diagnostics. Intraosseous infusion directly ensures peak concen...

Embodiment 2

[0142] Example 2: Addressing Sampling Errors

[0143] In cancer diagnosis, there are three main sources of sample error. The first source was "dry aspiration", where bone marrow could not be obtained (6.8% of aspirates). While this can be seen in normal patients, it can represent significant disease, such as inability to obtain fluid marrow when the marrow is tightly packed with tumor cells. It can also occur after chemotherapy (when all stem cells in the bone marrow are ablated) and in fibrotic bone marrow as in the disorder myelofibrosis. The second source was aspicular samples (20.6% aspirate). This is due to the combination of the small sampling area and the random distribution of hematopoietic marrow containing spicules in the skeleton. This occurs when the sampling needle is in an area containing fatty marrow rather than red hematopoietic marrow. This bone marrow distribution is easy to see on MRI, but it is very troublesome to guide each puncture with MRI.

[014...

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Abstract

The present invention provides improved devices for biopsy, aspiration, stem cell acquisition, and methods of using the same. The devices balance aspiration with concurrent infusion to manage changesin pressure at the site of biopsy. The present invention can be adapted for any biopsy, aspiration, or cell harvest procedure, including adipose tissue aspiration and bone marrow aspiration (BMA). Inparticular, the present invention limits patient pain, prevents blood contamination, and increases cell mobilization, such as improved stem cell yields with intraosseous (10) pharmacological mobilization of stem cells during a BMA procedure, and with improved stem cell yields using pharmacological mobilization of stem cells from fat. The pharmacological mobilization of cells allows the harvest ofcells from a biopsy many fold larger than existing methods.

Description

[0001] Citations to related applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 411,780, filed October 24, 2016, and U.S. Provisional Patent Application No. 62 / 504,090, filed May 10, 2017, the contents of which are each incorporated by reference Incorporated into this article as a whole. Background technique [0003] Stem cells are harvested in a variety of ways. The most common of these are obtained from fat cells and bone marrow. Bone marrow aspirate (BMA) for bone marrow transplantation, blood cancer diagnosis, and regenerative medicine purposes. In the United States, approximately 700,000 BMA procedures are performed annually for blood cancer diagnosis, and an estimated 500,000-1,000,000 BMA procedures are performed annually for stem cell therapy and plastic surgery. In cancer, BMA is used to diagnose, monitor, and study hematological malignancies, but poor sampling limits up to 27% of diagnostic samples. Sufficient numb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B10/02
CPCA61B10/0275A61B10/0283A61B2010/0258A61B10/025
Inventor 詹姆斯·埃利奥特·布朗布莱克·汤姆森朱丽安娜·沙维尔-费鲁西奥黛安娜·克劳斯斯蒂芬妮·哈莱内
Owner YALE UNIV
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