Novel method for constructing nomogram of multiple myeloma

A construction method and nomogram technology, applied in the field of multiple myeloma nomogram construction, can solve the problems of not establishing an effective and simple MM prognosis model

Active Publication Date: 2019-09-03
SHANGHAI TISSUEBANK MEDICAL LAB CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the heterogeneity of multiple myeloma has been paid more and more attention, however, no effective and simple MM prognostic model has been established in the world

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  • Novel method for constructing nomogram of multiple myeloma
  • Novel method for constructing nomogram of multiple myeloma
  • Novel method for constructing nomogram of multiple myeloma

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Embodiment Construction

[0041] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments It is some embodiments of the present invention, but not all of them. Based on the implementation manners in the present invention, all other implementation manners obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention. Accordingly, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the invention. Based on the implementation manners in the present invention, all other implement...

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Abstract

The invention provides a method for constructing a nomogram of multiple myeloma based on ten gene characteristics, serum [beta]2 microglobulin and LDH. The method comprises the following steps: S1, obtaining a gene expression profile GSE24080 of an MM patient from a GEO database, and pre-treating genes in the gene expression profile GSE24080 to obtain the first 25% of the 5413 genes with the largest variance in expression values; S2, subjecting the 5413 genes to WGCNA gene co-expression network analysis to identify function modules of co-expression; S3, evaluating the correlation between the functional modules and clinical information by Pearson correlation test to determine the most significant module; S4, performing univariate survival analysis on the genes in the most significant modules using a Cox proportional hazard model, and screening a score model consisting of 10 best genes by LASSO regression; and S5, establishing a novel nomogram based on the scoring model, serum [beta]2M and high LDH to predict 3-year OS and 5-year OS of newly diagnosed MM patients.

Description

technical field [0001] The invention relates to a multiple myeloma nomogram construction method based on ten gene characteristics, serum β2-microglobulin and LDH. Background technique [0002] Multiple myeloma (MM) is a malignant plasma cell disease in which tumor cells originate from plasma cells in the bone marrow, which are cells that develop to the final functional stage of B lymphocytes. At present, the heterogeneity of multiple myeloma has been paid more and more attention. However, no effective and simple MM prognostic model has been established in the world. Contents of the invention [0003] The present invention provides a multiple myeloma nomogram construction method based on ten gene characteristics, serum β2-microglobulin and LDH, which can effectively solve the above problems. [0004] The present invention is achieved like this: [0005] A method for constructing a multiple myeloma nomogram based on ten gene signatures, serum β2-microglobulin and LDH, comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/00G16B40/00G16B45/00G16H50/30
CPCG16H50/30G16B20/00G16B40/00G16B45/00
Inventor 曾志勇陈君敏
Owner SHANGHAI TISSUEBANK MEDICAL LAB CO LTD
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