Application of GOLT1B in prognosis of kidney cancer

A prognostic and quantitative detection technology, applied in the field of kidney cancer diagnosis, can solve the problems of low 5-year survival rate, recurrence and metastasis of patients, and achieve good clinical value

Pending Publication Date: 2022-01-18
戴勇 +1
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Problems solved by technology

On the other hand, a large proportion of patients with early renal cell carcinoma will eventually relapse and metastasize after surgery, and the 5-year survival rate of patients is low
However, there is currently no ideal molecular index to evaluate the risk of prognosis in clinical practice.

Method used

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  • Application of GOLT1B in prognosis of kidney cancer
  • Application of GOLT1B in prognosis of kidney cancer
  • Application of GOLT1B in prognosis of kidney cancer

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Search and analyze the differential expression data of GOLT1B in renal cancer and normal renal tissue in the TCGA library, the results are as follows Figure 1~3 shown, where Figure 1 ~ Figure 3 They are the control results of KICH, KIRC, KIRP patients and normal people respectively. In the figure, the abscissa Tumor is kidney cancer patients, Normal is normal human tissue or paracancerous tissue, and the ordinate is Transcripts Per Million (TPM) normalization (+0.001) and Take the logarithmic value. It can be seen from the figure that the expression of GOLT1B was significantly increased in KIRC and KIRP compared with normal tissue or paracancerous tissue.

[0029] The prognostic value of GOLT1B in renal cancer patients was further analyzed using the RNA-Seq data and patient survival time information in the TCGA database. The survival curve was calculated by the Kaplan-Meier method, and the logrank test was statistically significant. The result is as Figure 4~6 As ...

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Abstract

The invention discloses application of GOLT1B in diagnosis and prognosis of kidney cancer. On the first aspect, the invention provides application of a reagent for quantitatively detecting GOLT1B in preparation of a kit for diagnosis and / or prognosis of kidney cancer. According to the application of the embodiment of the invention, at least the following beneficial effects are achieved: genes or proteins thereof differentially expressed in kidney cancer and normal kidney tissues are screened through a series of bioinformatics analysis methods, the GOLT1B genes or GOLT1B proteins are proposed for the first time to serve as biomarkers for kidney cancer diagnosis or judgment of prognosis of kidney cancer, the defects of existing kidney cancer diagnosis indexes are overcome, and the clinical diagnosis value is good.

Description

technical field [0001] The present application relates to the technical field of kidney cancer diagnosis, especially the application of GOLT1B in the prognosis of kidney cancer. Background technique [0002] Kidney cancer is one of the most common malignant tumors of the urinary system, and the most common type of kidney cancer is renal cell carcinoma, which accounts for about 90% of kidney cancers. Renal cell carcinoma can be divided into renal clear cell carcinoma, renal papillary cell carcinoma, and renal chromophobe cell carcinoma according to histopathology. In recent years, the incidence of renal cell carcinoma has been increasing year by year. Moreover, early diagnosis of renal cell carcinoma is difficult. When patients present with clinical symptoms, about 30% of patients have metastasized. On the other hand, a large proportion of patients with early renal cell carcinoma will eventually relapse and metastasize after surgery, and the 5-year survival rate of patients ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158
Inventor 戴勇张巍汤冬娥徐勇蔡晚霞
Owner 戴勇
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