Application of GOLT1B in prognosis of kidney cancer
A prognostic and quantitative detection technology, applied in the field of kidney cancer diagnosis, can solve the problems of low 5-year survival rate, recurrence and metastasis of patients, and achieve good clinical value
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[0028] Search and analyze the differential expression data of GOLT1B in renal cancer and normal renal tissue in the TCGA library, the results are as follows Figure 1~3 shown, where Figure 1 ~ Figure 3 They are the control results of KICH, KIRC, KIRP patients and normal people respectively. In the figure, the abscissa Tumor is kidney cancer patients, Normal is normal human tissue or paracancerous tissue, and the ordinate is Transcripts Per Million (TPM) normalization (+0.001) and Take the logarithmic value. It can be seen from the figure that the expression of GOLT1B was significantly increased in KIRC and KIRP compared with normal tissue or paracancerous tissue.
[0029] The prognostic value of GOLT1B in renal cancer patients was further analyzed using the RNA-Seq data and patient survival time information in the TCGA database. The survival curve was calculated by the Kaplan-Meier method, and the logrank test was statistically significant. The result is as Figure 4~6 As ...
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