Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Animal experimental method of nerve stimulation to inhibit atrial fibrillation

An animal experiment and nerve stimulation technology, applied in the field of animal experiment, can solve the problems of high treatment cost and high efficacy, and achieve the effect of optimizing product design and function development

Inactive Publication Date: 2019-10-22
ZHEJIANG UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, catheter ablation only has a high curative effect on paroxysmal atrial fibrillation, and the treatment cost is high. It is of great practical significance to explore an effective and low-cost atrial fibrillation therapy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Animal experimental method of nerve stimulation to inhibit atrial fibrillation
  • Animal experimental method of nerve stimulation to inhibit atrial fibrillation
  • Animal experimental method of nerve stimulation to inhibit atrial fibrillation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0021] 1. Experimental study on the prevention of atrial fibrillation induced by low-intensity radial nerve stimulation

[0022] 1.1 Experimental purpose and principle

[0023] 1.1.1 Purpose of animal experiments

[0024] (1) Establish a model of acute atrial fibrillation induced in dogs.

[0025] (2) To clarify the impact of acute atrial fibrillation on the acute electrophysiological remodeling of the atrium.

[0026] (3) Through animal experiments, explor...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

An animal experimental method of nerve stimulation to inhibit atrial fibrillation comprises the steps: step 1, measuring and recording the effective refractory period, the atrial fibrillation induction window and the atrial fibrillation induction threshold of six measurement points in an atrium of an experimental dog at a baseline; step 2, using an induced atrial fibrillation stimulator; step 3, repeating the step 2, measuring and recording one hour later after rapid atrial pace-making; step 4, inserting two sterile acupuncture needles into a radial nerve trunk, forming a stimulation circuit,connecting electric stimulation ends at the ends, and carrying out low-intensity electric stimulation of the radial nerve trunk at the right side with the intensity 30% of the threshold intensity of the radial nerve trunk; and step 5, carrying out low-intensity electric stimulation of the radial nerve trunk at the right side with the intensity 50% of the threshold intensity of the radial nerve trunk. Through the study of dog atrial fibrillation, the parameters of the wireless portable nerve stimulator, such as the stimulation threshold, stimulation frequency, stimulation duration and optimal peripheral nerve stimulation site for effective suppression of the atrial fibrillation, are determined, and the product design and function development of the wireless portable nerve stimulator are optimized.

Description

technical field [0001] The invention relates to an animal experiment method, in particular to an animal experiment method for nerve stimulation to suppress atrial fibrillation. Background technique [0002] Atrial fibrillation (AF) is one of the most common arrhythmias in cardiovascular diseases. The incidence of atrial fibrillation is high, and the prevalence rate increases significantly with age. The current drug treatment is not effective, and its mechanism is not particularly clear . Atrial fibrillation may be the result of a combination of mechanisms. In 1947, Scherf et al. used aconitine to induce atrial fibrillation after local injection of the atrial appendage in dogs. After clamping the root of the atrial appendage with clamps, the electrical conduction between the atrial appendage and the atrium was blocked. The atrial appendage still maintained atrial fibrillation, but other parts of the atrium Maintain sinus rhythm. In 1950, Scherf et al. further researched an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/39A61N1/362A61N1/37
CPCA61N1/362A61N1/3702A61N1/371A61N1/3904A61N1/395
Inventor 孙勇樊友启朱国忠
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com