62 results about "Peripheral nerve stimulation" patented technology

The invention discloses a peripheral nerve stimulation system based on muscle fatigue prediction and compensation, which is used for acquiring electromyographic signals and predicting muscle fatigue states during nerve stimulation, and timely warning and adjusting stimulation to ensure the stability of muscle strength, and comprises a stimulation output module used for stimulating target nerves to activate target muscles according to stimulation parameters; the acquisition and analysis module is used for synchronously acquiring electromyographic signals of target muscles, preprocessing the electromyographic signals and extracting electromyographic signal features; the fatigue prediction module is used for predicting the fatigue state of the muscle according to the electromyographic signal characteristics; the compensation control module is used for adjusting stimulation parameters according to the fatigue state of the muscle and sending the stimulation parameters to the stimulation output module to ensure that the muscle strength is stable in the stimulation process; and the user interaction module is used for performing stimulation control and setting in real time and displaying the stimulation effect and the muscle fatigue state. Muscle fatigue and strength attenuation in the peripheral nerve stimulation process can be dynamically predicted and compensated in time, and the safety, accuracy and reliability of nerve stimulation are improved.

Disclosed herein are systems, devices, and methods for peripheral nerve stimulation, particularly for treating tremor. The nerve stimulation may be accomplished by a wearable nerve stimulation device, such as a band configured to be worn on the wrist or other body part. The device can accomplish targeted nerve stimulation using circumferentially spaced electrodes. In some embodiments, the device may use only the same number of electrodes as the number of nerves that are to be stimulated. A biphasic charge-balanced waveform may be used to selectively stimulate a nerve near one of the activated electrodes but not to stimulate the nerve near the other activated electrode. The device may use dry electrodes for long-term, repeated use. The dry electrodes may include a conductive base layer and a polymeric, plastic or rubber skin contact layer comprising a conductive filler. The filler may be a powder, fiber, conductive coating, etc.

A system and method for providing therapy to a patient can include a monitoring unit and a therapy unit. The monitoring unit can have a user interface and one or more sensors to measure patient data. The therapy unit can have a stimulator for generating electrical stimulation and a microcontroller for controlling the generation of the electrical stimulation based on the measured patient data.

Systems and methods are disclosed for the treatment and prevention of cardiac dysrhythmias and / or hypertension, and more specifically to systems and methods of treating cardiac dysrhythmias, including atrial fibrillation, as well as hypertension through noninvasive peripheral nerve stimulation.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator can have electrodes that are placed circumferentially around the patient's wrist or arm. Specific nerves in the wrist or arm can be targeted by appropriate spacing of the electrodes. Positioning the electrodes on generally opposing sides of the target nerve can result in improved stimulation of the nerve. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate tremor feedback, external data, predictive adaptation, and long-term monitoring data.

A system and method for providing therapy to a patient can include a monitoring unit and a therapy unit. The monitoring unit can have a user interface and one or more sensors to measure patient data. The therapy unit can have a stimulator for generating electrical stimulation and a microcontroller for controlling the generation of the electrical stimulation based on the measured patient data.

A wearable neurostimulation device is provided for providing transcutaneous peripheral nerve stimulation to a user. The neurostimulation device may include an enclosure housing the electronics for generating electric neurostimulation signals and an adjustable band detachably coupled to the enclosure. The enclosure may include a stimulation button and one or more auxiliary buttons. The band may be configured to be worn by a user, such as around the user's wrist or arm. The band may include a locking tab which prevents the loop from being opened. The band may comprise electrodes positioned to stimulate the user's radial and median nerves. Also provided is a charger for holding and charging the neurostimulation device. The band may include an RFID tag that wireless communicates with an RFID antenna in the charger. The charger may not charge the neurostimulation device if the band is determined to be beyond a threshold age.

Systems and methods are disclosed for the treatment and prevention of cardiac dysrhythmias and / or hypertension, and more specifically to systems and methods of treating cardiac dysrhythmias, including atrial fibrillation, as well as hypertension through noninvasive peripheral nerve stimulation.

Obstructive sleep apnea from blockage of the upper airway can result in significant health issues. Described herein is an intelligent personalized closed loop neuromodulation system and methods to prevent backwards movement of the genioglossus muscle through stimulation of certain branches of the hypoglossal nerve and muscle motor points, by using muscle feedback from electromyogram sensors to provide optimal stimulus. Alternative embodiments to treat neuropathic pain and urinary dysfunction are enclosed.

The invention discloses a peripheral nerve stimulation threshold prediction method of a magnetic resonance gradient coil and application thereof. The method comprises the following steps: firstly, designing a reference coil group with differentiated electromagnetic parameters based on a target gradient coil space structure; then combining a high-precision virtual human body anatomical model and an electromagnetic-neurodynamics coupling model, calculating the induction electric field distribution and stimulation threshold of each coil, and positioning sensitive neuron nodes; expressing a stimulation function as a weighted sum of a local magnetic vector potential component, constructing a linear equation set, and solving an optimal coefficient by adopting a least square method; and finally, establishing a linear regression model of a stimulation function and a threshold reciprocal, and defining a prediction function based on a local field. The prediction method provided by the invention has both calculation efficiency and prediction precision, can further derive a magnetic resonance coil peripheral nerve stimulation threshold curve for real-time evaluation of stimulation risks in imaging scanning, and can also introduce a coil design framework to realize electromagnetic optimization design of a high-threshold gradient coil.

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a light source and a speaker. A visual neural stimulation system provides, via the light source, visual stimulation having a first value of a first parameter. An auditory neural stimulation system provides, via the speaker, audio stimulation having a second value of the second parameter. A stimuli orchestration component selects, for a first time interval, one of the visual stimulation or the audio stimulation to vary based on a policy, selects, for the first time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy, and provides causes the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation.

Systems and methods are disclosed for the treatment and prevention of cardiac dysrhythmias and / or hypertension, and more specifically to systems and methods of treating cardiac dysrhythmias, including atrial fibrillation, as well as hypertension through noninvasive peripheral nerve stimulation.

The present disclosure relates to a muscle or nerve function rehabilitation assistance device using electrically conductive hydrogel. The electrically conductive hydrogel (IT-IC) provides an electrophysiological interface function between electrically active tissues, enabling the filling of lost muscle or nerve tissue for immediate rehabilitation in the early stages. It facilitates electrophysiological signal transmission between tissues and accelerates myofiber regeneration during the recovery phase. Particularly, when the electrically conductive hydrogel (IT-IC) is applied, the transmission of electrical signals generated in the muscle can be precisely controlled by a closed-loop device capable of being feedback in conjunction with peripheral nerve stimulation and electromyogram (EMG) monitoring.

The invention provides a peripheral nerve precise regulation and control method and system based on a multi-channel flexible electrode, and is applied to the technical field of data processing. Physiological parameter information of a target user is processed based on a target peripheral nerve stimulation model, muscle contraction characteristic comprehensive indexes are generated, the muscle contraction characteristic comprehensive indexes comprise muscle contraction amplitude and contraction frequency, and the contraction frequency is clearly distinguished according to fast muscles, slow muscles and different motion modes; processing the training purpose information and the muscle contraction characteristic comprehensive index of the target user based on the target peripheral nerve stimulation model, and generating a preliminarily adjusted muscle contraction signal; processing the preliminarily adjusted muscle contraction signal based on the physiological feature information of the target organ to generate a secondarily adjusted muscle contraction signal; and processing the muscle contraction signal after secondary adjustment based on the motion intensity interval information of the target organ, and generating a target peripheral nerve stimulation signal.

The invention discloses a wearable multi-channel peripheral nerve electric pulse generating device, belongs to the field of electrotherapy of applying current through a contact electrode, and aims to solve the problems that an existing nerve electric pulse generating device is insufficient in precision, poor in portability and limited in number of stimulation channels. The device comprises a wearable arm clamp mechanism and a modular flexible electrode patch, the wearable arm clamp mechanism comprises a circuit board bin, a battery bin and an arm clamp, the arm clamp is of an arc-shaped structure attached to the big arm of the human body, the circuit board bin and the battery bin are inserted into the upper end and the lower end of the arm clamp respectively, and a battery power source is arranged in the battery bin; a control unit MCU and a constant-current pulse generation circuit are arranged in the circuit board bin, and the modular flexible electrode paste is inserted into the circuit board bin; the constant-current pulse generation circuit generates and adjusts an electric pulse signal required by peripheral nerve stimulation under the control of the control unit MCU, and sends the electric pulse signal to the modularized flexible electrode patch attached to a specific position.

Systems, devices, and methods for stimulating peripheral nerves in the fingers or hand to treat tremor are described. For example, a wearable ring device for delivering electrical stimulation to sensory nerves in a patient's finger can include an annular ring having a plurality of electrodes and a detachable unit having a power source and a pulse generator.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

A Peripheral Nerve Stimulation (PNS) system and method are disclosed. The system includes a headset with ear hooks and electrodes for placement on the mastoid processes. A stimulation device connected to the headset via lead wires delivers a pulsed electrical current to the electrodes. The device communicates with a computing device equipped with a mobile application that controls the stimulation characteristics. The mobile application allows users to adjust settings, monitor progress, and access treatment sessions. The system also includes snap ports for electrode attachment, self-adhesive hydrogel electrodes, and current control mechanisms using a digital potentiometer and waveform generator. The method includes pre- and post-session anxiety rating, personalized treatment based on user inputs, and tracking of physiological biomarkers. The application supports multiple operating systems, secure cloud data storage, and enables data sharing with healthcare providers. The invention provides a comprehensive, customizable, safe solution for managing anxiety and insomnia.

The application provides a peripheral nerve precise regulation method and system based on a multi-channel flexible electrode, and is applied to the technical field of data processing. The physiological parameter information of a target user is processed based on a target peripheral nerve stimulation model to generate a muscle contraction characteristic comprehensive index, wherein the muscle contraction characteristic comprehensive index includes a muscle contraction amplitude, a contraction frequency, and the contraction frequency is clearly distinguished according to fast muscle, slow muscle and different movement modes. The training purpose information and the muscle contraction characteristic comprehensive index of the target user are processed based on the target peripheral nerve stimulation model to generate a preliminarily adjusted muscle contraction signal. The preliminarily adjusted muscle contraction signal is processed based on the physiological characteristic information of a target organ to generate a secondarily adjusted muscle contraction signal. The secondarily adjusted muscle contraction signal is processed based on the movement intensity interval information of the target organ to generate a target peripheral nerve stimulation signal.

The invention provides a system and method for peripheral nerve stimulation to treat tremor with a removable treatment and monitoring unit. Systems and methods for providing treatment to a patient may include a monitoring unit and a treatment unit. The monitoring unit may have a user interface and one or more sensors to measure patient data. The treatment unit may have a stimulator that generates electrical stimulation and a microcontroller that controls the generation of electrical stimulation based on measured patient data.

A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinsonian tremor, and other forms of tremor. The stimulator can have electrodes that are placed circumferentially around the patient's wrist or arm. Specific nerves in the wrist or arm can be targeted by appropriate spacing of the electrodes. Positioning the electrodes on generally opposing sides of the target nerve can result in improved stimulation of the nerve. The stimulation pattern may alternate between the nerves. Improved stimulation algorithms can incorporate tremor feedback, external data, predictive adaptation, and long-term monitoring data.

The invention provides a peripheral nerve stimulation system. The peripheral nerve stimulation system comprises a stimulation front end, a release part, a wire and a base, the stimulation front end and the release part are used for being implanted into a body, and the stimulation front end is used for being connected with a target nerve; the base is used for being arranged outside a body; the two ends of the wire are connected with the base and the stimulation front end respectively. The base is configured to send stimulation energy to the stimulation front end through the wire; wherein the stimulation front end is configured to be degradable, and the release part is configured to drive the wire to be released and separated from the stimulation front end when receiving release energy from the base; after the lead is disengaged from the stimulation front end, the lead is configured to be removed from the body. By means of the configuration, the precision and effectiveness of intraoperative electrical stimulation treatment and the convenience of percutaneous electrical stimulation treatment are achieved at the same time, and a secondary operation can be omitted after treatment is completed.

The present invention relates to a nerve conduit comprising: a conduit body that connects both sides of a severed nerve within a living body; a triboelectric generator electrically connected to the severed nerve through the conduit body to transmit an electrical signal generated by the application of ultrasound to the severed nerve; and an encapsulation layer covering the triboelectric generator, wherein the conduit body, the triboelectric generator, and the encapsulation layer are made of biodegradable materials. This invention is an output of the research project "SONOSTIM: Ultrasound-Based Triboelectric Generator Applied to Electronic Nerve Stimulation Technology for Pain-Free Peripheral Nerve Stimulation," supported by the Ministry of SMEs and Startups, managed by the Korea Technology and Information Promotion Agency for SMEs, as part of the Entrepreneurship-Oriented University Program (Project ID: 20176104), with Energy Mining as the executing institution. The research period was from 1 May 2023, to 31 December 2023.

To provide a system and a method for treating a patient suffering from tremor.SOLUTION: A system for treating a patient suffering from tremor includes: a pulse generator; and a circumferential band that is applied to be fixed to the patient's arm or wrist, that is, a band that supports first and second electrodes for electrically communicating with the pulse generator.SELECTED DRAWING: Figure 1

Obstructive sleep apnea from blockage of the upper airway can result in significant daytime drowsiness, with many long-term co-morbidities associated with this disorder such as such as hypertension. A common cause of obstructive sleep apnea is the complete concentric collapse of the soft pallet or retrusion of the genioglossus muscle into the upper airway obstructing breathing. The latter can be due to exhaustion of the muscle due to heightened activation during wake periods, or a greater number of type II muscle fibers can contribute to muscle fatigue. It could also be neurological, whereby the hypoglossal nerve which controls most the upper airway muscles fails to innervate the genioglossus sufficiently to prevent backward movement and pharyngeal block. Described herein is an intelligent personalized closed loop neuromodulation system and methods to prevent backwards movement of the genioglossus muscle through stimulation of certain branches of the hypoglossal nerve and muscle motor points, by using muscle feedback from electromyogram sensors to provide optimal stimulus. Alternative embodiments to treat neuropathic pain and urinary dysfunction are enclosed.

A method for assessing peripheral nerve stimulation (PNS) for a coil geometry includes retrieving a PNS Huygens' P-matrix for a body model. The PNS Huygens' P-matrix is defined on a Huygens' surface enclosing the body model. The method further includes generating a coil specific PNS P-matrix for the coil geometry based on at least the PNS Huygens' P-matrix for the body model, determining at least one PNS threshold for the coil geometry based on the coil specific PNS P-matrix, and storing the at least one PNS threshold in a storage device.

Apparatus and methods for managing pain uses a single composite modulation / stimulation signal with variable characteristics to achieve the same results as separate varying electromagnetic signals, including spinal cord stimulation or peripheral nerve stimulation.

The application discloses a kind of for peripheral nerve stimulation optical genetic system, the system includes: light stimulation module, terminal control module and host computer;The light stimulation module includes μLED and the lead wire connected with the positive and negative electrode of μLED, the light stimulation module is implanted in the site required to stimulate, for regulating the neuron activity of the site;The terminal control module includes terminal circuit board and battery, the terminal circuit board is connected with the lead wire, the battery is detachably connected with the terminal circuit board, the terminal control module is fixed on experimental body, for controlling μLED;The host computer is established wireless communication with the terminal control module, for inputting light stimulation parameter and acting on the experimental body, and receiving the working state information of μLED.It is convenient to use the optical genetic system in the application, not limited by the behavior of experimental body, meet the experimental demand, improve the operability of optical genetic system.

Systems and methods of the present disclosure are directed to systems and methods for treating cognitive dysfunction in a subject in need thereof. The system can include a light source and a speaker. A visual neural stimulation system provides, via the light source, visual stimulation having a first value of a first parameter. An auditory neural stimulation system provides, via the speaker, audio stimulation having a second value of the second parameter. A stimuli orchestration component selects, for a first time interval, one of the visual stimulation or the audio stimulation to vary based on a policy, selects, for the first time interval, the other of the visual stimulation or the audio stimulation to keep constant based on the policy, and provides causes the one of the visual neural stimulation system or the auditory neural stimulation system to vary the one of the visual stimulation or the audio stimulation.

Apparatus and methods for managing pain uses a single composite modulation / stimulation signal with variable characteristics to achieve the same results as separate varying electromagnetic signals, including spinal cord stimulation or peripheral nerve stimulation.