Blood purification device

A technology of blood purification and blood, which is applied in the direction of blood circulation treatment, blood filtration, and other medical devices, and can solve problems such as calcium concentration reduction

Active Publication Date: 2019-10-25
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, when citric acid is used as an anticoagulant, ionized calcium in blood decreases due to the action of citric acid, and Ci-Ca complexes (a type of calcium complex) increase, and most of them are The blood purification membrane of the blood purifier is removed, so the calcium concentration in the blood returned to the patient after passing through the blood purifier is significantly reduced

Method used

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no. 1 approach

[0030] figure 1 It is an explanatory diagram showing the outline of the configuration of the blood purification device 1 according to the present embodiment. The blood purification device 1 of the present embodiment is a device for performing hemodiafiltration (HemoDiaFiltration).

[0031] The blood purification device 1 includes, for example, a blood purifier 10, a blood circuit 11, a citric acid solution supply unit 12, a calcium solution supply unit 13, a dialysate circuit 14, a fluid replacement circuit 15, a control device 16, and the like.

[0032] The blood purifier 10 has a blood purification membrane 20 formed of a hollow fiber membrane or the like in a cylindrical module. Blood purifier 10 has liquid ports 10a, 10b communicating with the primary side (blood side) of blood purification membrane 20 and liquid ports 10c, 10d communicating with the secondary side (dialysate side) of blood purification membrane 20 .

[0033] The blood circuit 11 has, for example, a blo...

no. 2 approach

[0063] Next, a case where the present invention is applied to a blood purification apparatus 100 for performing hemodialysis (HemoDialysis) will be described as an example. Figure 4 It is an explanatory diagram showing the outline of the configuration of the blood purification device 100 according to the present embodiment.

[0064] Compared with the blood purification device 1 of the first embodiment, the blood purification device 1 does not include, for example, the liquid replacement circuit 15 .

[0065] The control device 16 calculates the supply flow rate Qca of the calcium solution supplied from the calcium solution supply unit 13 to the blood circuit 11 by the following equation (2).

[0066] Qca={{(Qd×kd+Qf×kf)×Ctca×kca} / Cica}···(2)

[0067] Ctca is the target calcium ion concentration in the patient's blood.

[0068] Cica is the calcium solution concentration of the calcium solution supply unit.

[0069] kca is a constant used when calculating the calcium concent...

no. 3 approach

[0078] Next, a case where the present invention is applied to a blood purification device 200 for performing blood filtration (HemoFiltration) will be described as an example. Figure 5 It is an explanatory diagram showing the outline of the configuration of the blood purification device 200 according to this embodiment.

[0079] Compared with the blood purification device 1 of the first embodiment, the blood purification device 200 does not include, for example, the dialysate circuit 14 , and instead includes a waste liquid circuit 201 .

[0080] The waste liquid circuit 201 communicates, for example, from the liquid port 10d of the blood purifier 10 to a waste liquid portion outside the device. A waste liquid pump 202 is provided in the waste liquid circuit 201 . In addition, the liquid communication port 10c is closed.

[0081] The control device 16 calculates the supply flow rate Qca of the calcium solution supplied from the calcium solution supply unit 13 to the blood c...

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Abstract

Provided is a blood purification device that comprises a blood circuit, a blood purifier, a citric acid solution supplying means, and a calcium solution supplying means. The blood purification deviceis configured so as to: estimate a calcium reduction quantity for reduction in the blood circuit overall, including a removal quantity of calcium to be removed with the blood purifier when blood of atarget calcium ion concentration flows through the blood circuit, on the basis of a target calcium ion concentration of patient blood that has been inputted; calculate a supplied quantity of calcium solution to be supplied to the blood circuit on the basis of the calcium reduction quantity; and supply the calcium solution to the blood circuit with the calcium solution supplying means on the basisof the supplied quantity of calcium solution.

Description

technical field [0001] This application is based on Japanese Patent Application No. 2017-039749 filed on March 2, 2017, and the content of the description is cited here. [0002] The invention relates to a blood purification device. Background technique [0003] Blood purification treatment performed in dialysis treatment, plasma exchange treatment, and the like is generally performed using a blood purification device. This blood purification device includes a blood purifier and a blood circuit for sending blood taken from a patient to the blood purifier and returning the blood purified by the blood purifier to the patient. [0004] In order to prevent the patient's blood from coagulating in the blood circuit, conventionally, an anticoagulant is injected into the blood circuit upstream of the blood purifier. [0005] Conventionally, heparin has been used as an anticoagulant, but in recent years, it has been proposed to use citric acid, which has less burden on the blood pu...

Claims

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Application Information

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IPC IPC(8): A61M1/36A61M1/34
CPCA61M1/3672A61M2205/3327A61M2205/50A61M2230/20A61M1/342A61M1/3434A61M1/3437
Inventor 海本隆志巴勃罗·多西尔·罗森德
Owner ASAHI KASEI MEDICAL CO LTD
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