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Semi-synthesis method of luteolin

A semi-synthetic technology of luteolin, applied in the direction of organic chemistry, can solve the problems of unsuitability for industrial production, and achieve the effects of short reaction time, low cost and high yield

Active Publication Date: 2019-11-19
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But what this method adopted is the microwave reflux heating method, is not suitable for industrialized production

Method used

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  • Semi-synthesis method of luteolin
  • Semi-synthesis method of luteolin
  • Semi-synthesis method of luteolin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Raw materials: in parts by weight, 800 parts of distilled water, 4 parts of rutin, and 10 parts of thiourea.

[0026] Preparation method: boil distilled water, add rutin, add NaOH to control the pH to 8-9, add thiourea, react at 60°C for 2 hours, neutralize the pH to 2-4 with concentrated HCl, cool and stand for crystallization, Filtrate, wash and dry to obtain luteolin with a yield of 99.1% and a purity of 95.31%. Figure 4 and Figure 5 shown.

Embodiment 2

[0028] Raw materials: in parts by weight, 800 parts of distilled water, 4 parts of rutin, and 10 parts of thiourea.

[0029] Preparation method: boil distilled water, add rutin, add NaOH to control the pH to 8-9, add thiourea, react at 60°C for 3 hours, neutralize the pH to 2-4 with concentrated HCl, cool and stand for crystallization , filtered, washed and dried to obtain luteolin with a yield of 97.1% and a purity of 95.43%.

Embodiment 3

[0031] Raw materials: in parts by weight, 800 parts of distilled water, 4 parts of rutin, and 10 parts of thiourea.

[0032] Preparation method: boil distilled water, add rutin, add NaOH to control the pH to 8-9; add thiourea, react at 60°C for 4 hours, neutralize the pH to 2-4 with concentrated HCl, cool and stand for crystallization , filtered, washed and dried to obtain luteolin with a yield of 97.1% and a purity of 95.09%.

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Abstract

The invention specifically relates to a semi-synthesis method for luteolin, belonging to the technical field of substance synthesis. The semi-synthesis method comprises the following concrete steps: with rutin as a raw material and a urea compound as a reducing agent, carrying out a reaction for 0.5-7 h at a temperature of 40 DEG C to a reflux state, and then performing refining so as to obtain luteolin. The prepared luteolin has a yield of greater than 97.1% and a purity of greater than 94.22%.

Description

technical field [0001] The invention belongs to the technical field of substance synthesis, and in particular relates to a semi-synthetic method of luteolin. Background technique [0002] Flavonoids are widely distributed in nature and exist in glycoside and free forms. Due to their diverse biochemical and pharmacological effects, including antioxidant activity, they have attracted extensive attention from scholars at home and abroad, and have become natural medicines at home and abroad. Development and utilization of research hotspots. Luteolin (luteoin, Huang Shiling) scientific name 3', 4', 5, 7-tetrahydroxyflavone, is a very representative natural flavonoid, which belongs to weakly acidic tetrahydroxyflavonoids, and is widely distributed in the plant kingdom. Wide; Luteolin has strong antioxidant activity; it has antibacterial, antiviral and lower blood lipid and cholesterol effects in the body. Luteolin has good antioxidant and antibacterial properties, and it has bro...

Claims

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Application Information

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IPC IPC(8): C07D311/30
CPCC07D311/30
Inventor 祝宝福曹华郭鹏峰余跃
Owner GUANGDONG PHARMA UNIV