Application of octenidine in inhibiting acetyltransferase and resisting mycobacterium infection

A technology of acetyltransferase and octenidine, applied in the field of pharmacy, can solve problems such as few protease studies
CN110787164AInactive Publication Date: 2020-02-14TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE
Publication Date
2020-02-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The embodiment of the invention provides application of octenidine in inhibiting acetyltransferase and resisting mycobacterium infection. The structure formula of the octenidine is as shown. Experiments show that the octenidine can well inhibit acetyltransferase and has a remarkable inhibition effect on mycobacterium tuberculosis and clinical mycobacterium tuberculosis wide drug-resistant strains499 and 421.
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Description

technical field

[0001] The invention relates to the technical field of pharmacy, in particular to the application of octenidine in inhibiting acetyltransferase and resisting mycobacterium infection. Background technique

[0002] Tuberculosis (TB) is an infectious disease caused by Mycobacterium tubercuosis (Mtb). It is mainly transmitted through the respiratory tract and can cause symptoms such as cough, chest pain, hemoptysis, and dyspnea. It occurs when the body's immunity is weakened. According to estimates by the World Health Organization, despite vigorous efforts to curb tuberculosis infection worldwide, 10.4 million new patients develop tuberculosis (TB) each year, resulting in approximately 1.5 million deaths worldwide each year. In 1993, WHO declared a "global tuberculosis emergency", arguing that tuberculosis has become an important public health problem all over the world.

[0003] Tuberculosis was discovered in 1882 by German microbiologist Robert Koch. Microsc...

Claims

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