Marker and kit for early hepatic fibrosis diagnosis and application

A technology for early diagnosis and liver fibrosis, applied in disease diagnosis, biological testing, biomaterial analysis, etc. Tissue bile duct reaction, good effect on early liver fibrosis

Pending Publication Date: 2020-04-10
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Abstract
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  • Claims
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Problems solved by technology

[0004] Liver biopsy is currently the gold standard for clinical diagnosis of liver fibrosis staging, but liver biopsy is an invasive test, and liver fibrosis is unevenly distributed in liver tissue. The number of tissues is limited, especially when liver fibrosis occurs due to early liver injury, there are still some errors in judging the degree of liver fibrosis from biopsy histopathological results, and it is difficult to obtain dynamic observations repe...

Method used

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  • Marker and kit for early hepatic fibrosis diagnosis and application
  • Marker and kit for early hepatic fibrosis diagnosis and application
  • Marker and kit for early hepatic fibrosis diagnosis and application

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Embodiment Construction

[0032] The embodiments described below are exemplary, and are only used to explain the present application, and cannot be construed as limiting the present application. Also, detailed descriptions of known technologies will be omitted if they are unnecessary to illustrate the features of the present application.

[0033] An early diagnostic marker for liver fibrosis, including at least one of cytokeratin 19 (K19) and the fragment antigen CYFRA21-1 of cytokeratin 19, at least one of the early diagnostic markers for liver fibrosis Differential expression in the test sample and the control sample.

[0034] In one embodiment of the present application, among the early diagnostic markers of liver fibrosis, at least one of cytokeratin 19 and the fragment antigen CYFRA21-1 of cytokeratin 19 is different from that of the control in the liver tissue sample of the subject. Differentially expressed in liver tissue samples. Preferably, among the early diagnostic markers for liver fibros...

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Abstract

The invention provides a marker and kit for early hepatic fibrosis diagnosis and application.The marker comprises at least one of cytokeratin 19 and a fragment antigen CYFRA21-1 of the cytokeratin 19,and at least one of the liver fibrosis early diagnosis markers is differentially expressed in a test sample and a control sample. The marker for early diagnosis of hepatic fibrosis can realize diagnosis of early hepatic fibrosis.

Description

technical field [0001] The present application relates to the technical field of biological detection, in particular, the present application relates to a marker, kit and application for early diagnosis of liver fibrosis. Background technique [0002] Liver fibrosis is a common pathological change and the only way for various chronic liver diseases to develop into liver cirrhosis. The occurrence of fibrosis is an important factor in predicting chronic liver injury and disease progression, and it is very important to detect the early occurrence of liver fibrosis. [0003] Clinical diagnostic methods for liver fibrosis fall into two categories. One is invasive examination, that is, liver biopsy; the other is non-invasive examination, including serum molecular markers and imaging examinations. [0004] Liver biopsy is currently the gold standard for clinical diagnosis of liver fibrosis staging, but liver biopsy is an invasive test, and liver fibrosis is unevenly distributed i...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2333/4742G01N2800/085
Inventor 汪艳杨金连何彩萍
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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