Marker and kit for early hepatic fibrosis diagnosis and application

Abstract

The invention provides a marker and kit for early hepatic fibrosis diagnosis and application.The marker comprises at least one of cytokeratin 19 and a fragment antigen CYFRA21-1 of the cytokeratin 19,and at least one of the liver fibrosis early diagnosis markers is differentially expressed in a test sample and a control sample. The marker for early diagnosis of hepatic fibrosis can realize diagnosis of early hepatic fibrosis.

Description

technical field [0001] The present application relates to the technical field of biological detection, in particular, the present application relates to a marker, kit and application for early diagnosis of liver fibrosis. Background technique [0002] Liver fibrosis is a common pathological change and the only way for various chronic liver diseases to develop into liver cirrhosis. The occurrence of fibrosis is an important factor in predicting chronic liver injury and disease progression, and it is very important to detect the early occurrence of liver fibrosis. [0003] Clinical diagnostic methods for liver fibrosis fall into two categories. One is invasive examination, that is, liver biopsy; the other is non-invasive examination, including serum molecular markers and imaging examinations. [0004] Liver biopsy is currently the gold standard for clinical diagnosis of liver fibrosis staging, but liver biopsy is an invasive test, and liver fibrosis is unevenly distributed i...

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Problems solved by technology

[0004] Liver biopsy is currently the gold standard for clinical diagnosis of liver fibrosis staging, but liver biopsy is an invasive test, and liver fibrosis is unevenly distributed in liver tissue. The number of tissues is limited, especially when liver fibrosis occurs due to early liver injury, there are still some errors in judging the degree of liver fibrosis from biopsy histopathological results, and it is difficult to obtain dynamic observations repeatedly

[0005] Imaging examinations are also helpful in the diagnosis of liver fibrosis, but the diagnosis of early fibrosis is still difficult because the morphological changes of early liver fibrosis are not obvious

[0006] In the prior art, although serum molecular markers are related to liver inflammation activity, liver metabolism and other states, they cannot accurately reflect the degree of liver fibrosis, especially in the detection of early liver fibrosis.

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