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Application of syringaresinol in preparation of medicine for preventing and treating liver ischemia-reperfusion injury

A technology for reperfusion injury and syringaresinol, which is applied in the directions of drug combination, effective components of heterocyclic compounds, digestive system, etc., to achieve the effects of great social significance, economic benefits, and low toxic and side effects

Pending Publication Date: 2020-04-28
AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there is no relevant report about syringaresin in the preparation of drugs for the prevention and treatment of liver ischemia-reperfusion injury.

Method used

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  • Application of syringaresinol in preparation of medicine for preventing and treating liver ischemia-reperfusion injury
  • Application of syringaresinol in preparation of medicine for preventing and treating liver ischemia-reperfusion injury
  • Application of syringaresinol in preparation of medicine for preventing and treating liver ischemia-reperfusion injury

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Embodiment Construction

[0036] The principles and features of the present invention will be described below in conjunction with specific drawings, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention.

[0037] 1. Drugs, animals

[0038] Syringaresin was purchased from Sichuan Weikeqi Biotechnology Co., Ltd., CAS number: 21453-69-0, article number: wkq-05301, analytical standard, HPLC ≥ 98%.

[0039] The experimental animals were C57BL / 6 mice (male, 8-10 weeks old, weighing 22-25g), purchased from Hunan Slack Jingda Experimental Animal Co., Ltd., and kept at constant temperature (22-25°C) and constant humidity ( 50%-56%) of SPF grade animals are kept in the house.

[0040] The feed was provided by Hunan Slake Jingda Experimental Animal Co., Ltd.

[0041]All animal experiments involved in the present invention have been reviewed by the Animal Ethics Committee of Guilin Medical College.

[0042] 2. Experimental method ...

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Abstract

The invention discloses application of syringaresinol in preparation of a medicine for preventing and treating liver ischemia-reperfusion injury, and belongs to the technical field of syringaresinol application. According to the present invention, the drug experiment research results show that the syringaresinol is the natural traditional Chinese medicine monomer, has the low toxic-side effect, can be used for preparing the liver ischemia-reperfusion injury prevention and treatment drug, opens up the new liver ischemia-reperfusion injury prevention and treatment drug, and opens up the new useof the syringaresinol so as to provide the broad market prospects. And great social significance and economic benefits are achieved.

Description

technical field [0001] The invention relates to the application of syringaresin in the preparation of medicines for preventing and treating liver ischemia-reperfusion injury, and belongs to the technical field of syringaresin application. Background technique [0002] Hepatic Ischemia-Reperfusion Injury (Hepatic Ischemia-Reperfusion Injury, HIRI) refers to the re-supply of blood flow after a period of liver ischemia, which not only fails to restore and improve its function, but further aggravates tissue metabolic disorders and structural and functional damage. It is an inevitable pathological injury in the process of clinical hepatic lobectomy and liver transplantation, severe trauma to the liver, and hemorrhagic shock. HIRI includes two interrelated stages: ischemic injury and inflammation-mediated reperfusion injury. Ischemic injury is caused by glycogen consumption, lack of oxygen supply, ATP depletion and other ischemic stresses that lead to metabolic imbalance and diso...

Claims

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Application Information

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IPC IPC(8): A61K31/34A61P1/16
CPCA61K31/34A61P1/16
Inventor 金俊飞王永芹李春梅郭林政何婵婵董未
Owner AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
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