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Method for simultaneously measuring photo-thermal physical property parameters of biological tissues

A technology of biological tissue and physical property parameters, applied in the field of simultaneous measurement of photothermal physical property parameters of biological tissue, non-invasive measurement of internal photothermal physical property parameters of biological tissue, which can solve the problem of low measurement accuracy of biological tissue photothermal physical property parameters and limited biological tissue transmission. Thermal research development and application, instability and other issues

Active Publication Date: 2020-04-28
CHONGQING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are complex correlations between the photothermal physical parameters of biological tissues, and the sensitivity of the photothermal response signal on the tissue surface to its internal physical parameters shows obvious differences, resulting in low measurement accuracy of photothermal physical parameters of biological tissues. Seriously limit the development and application of biological tissue heat transfer research
[0004] To sum up, the problems existing in the existing technology are: the existing methods cannot realize the non-invasive simultaneous measurement of the photothermal physical parameters inside the biological tissue, the sensitivity of the photothermal measurement signal on the surface of the tissue is very different, and the photothermal physical parameters of the biological tissue cannot be measured at the same time. Low measurement accuracy seriously limits the development and application of biological tissue heat transfer research
However, the transmission of photothermal information in biological tissues is directional and along-the-way, and shows strong anisotropy, which leads to serious morbidity and strong instability in the simultaneous inversion of photothermal physical parameters of biological tissues; at the same time, biological There are complex correlations between the photothermal parameters of tissues. The photoresponse information and thermal response information on the surface of biological tissues have obvious differences in sensitivity to various photothermal parameters inside. How to reasonably integrate the photothermal parameters of the tissue surface It is an important problem to be solved urgently in the field of biological heat transfer to realize accurate measurement of its internal photothermal physical parameters.

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  • Method for simultaneously measuring photo-thermal physical property parameters of biological tissues
  • Method for simultaneously measuring photo-thermal physical property parameters of biological tissues
  • Method for simultaneously measuring photo-thermal physical property parameters of biological tissues

Examples

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Embodiment

[0109] Embodiment: The following is an example of simultaneous measurement of photothermal physical parameters of biological tissue using the method of the present invention.

[0110] In the calculation example, the geometric parameters of the studied biological tissue are set to L x = 40cm and L y =40cm; the density of biological tissue ρ=1000kg / m 3 , constant pressure specific heat capacity c p =4200J / (kg·℃), blood perfusion rate w b =1.0×10 -3 the s -1 ; Surface convective heat transfer coefficient is h=7W / (m 2 ·℃), the ambient temperature is T a =25℃, ambient refractive index n 0 =1.0, the refractive index of biological tissue n 1 = 1.4, the number of sampling points M = 20, the specified measurement accuracy ε = 10 -6 ; The initial given parameter vector is E=[κ a ,κ s ,λ]=[50,10000,1.0], the unit is m -1 、m -1 and W / (m·°C).

[0111] Calculation example one:

[0112] Taking human skin tissue as the research object, its real photothermal physical property pa...

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Abstract

The invention belongs to the technical field of measurement of photo-thermal physical property parameters of biological tissues, and discloses a method for simultaneously measuring photo-thermal physical property parameters of biological tissues. The method comprises the following steps: establishing a photo-thermal transmission model in a biological tissue under laser irradiation; selecting M sampling points on the surface of the biological tissue, and acquiring radiation intensity signals and temperature signals of the M sampling points by using a thermal infrared imager; calculating the radiation intensity and temperature at each sampling point on the measurement surface; establishing an objective function for measuring the photo-thermal physical property parameters of the biological tissue; and establishing a staged multi-step optimization module for simultaneously measuring the photo-thermal physical parameters of the biological tissue, and iteratively correcting the photo-thermalphysical parameter vector E of the biological tissue according to an optimization result. Through the staged multi-step optimization module, the sensitivity of the photo-thermal response signal to the photo-thermal physical property parameters of the biological tissue can be reasonably utilized, non-invasive measurement of photo-thermal physical property parameters in tissues can be realized, andan effective technical scheme is provided for simultaneous measurement of photo-thermal physical property parameters of biological tissues.

Description

technical field [0001] The invention belongs to the technical field of photothermal physical property parameter measurement of biological tissue, and relates to a method for simultaneously measuring photothermal physical property parameters of biological tissue, in particular to a non-invasive method for measuring internal photothermal physical property parameters of biological tissue. Background technique [0002] The photothermal physical parameters of biological tissue include optical characteristic parameters such as absorption coefficient and scattering coefficient, and thermal physical property parameters such as thermal conductivity and specific heat capacity. The photothermal physical parameter information of biological tissue is the basis for studying the photothermal transmission process inside the tissue, and its accurate measurement is of great significance for laser-induced tumor hyperthermia, cryopreservation and recovery of biological organisms, and biomedical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/483
CPCG01N33/4833
Inventor 孙双成王英乔
Owner CHONGQING UNIV
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