Method of improving bile duct cancer by TIL immune cells

A technology for immune cells and cholangiocarcinoma, applied in the field of immune cell therapy, can solve the problems of poor chemotherapy sensitivity and prolong survival period, and achieve the effects of less side effects, improved quality of life and strong curative effect.

Inactive Publication Date: 2020-05-26
卡替(上海)细胞生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

3. Chemotherapy: cholangiocarcinoma is not sensitive to chemotherapy, cholangiocarcinoma is less sensitive to chemotherapy than other gastrointestinal tumors such as colon cancer, but chemotherapy may relieve the symptoms caused by cholangiocarcinoma, improve the quality of life of patients, and may prolong the survival period

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Embodiment Construction

[0011] The present invention will be described in detail below in conjunction with specific embodiments.

[0012] The present invention discloses a method for improving cholangiocarcinoma through TIL immune cells. The specific operation steps of the method are: (1) first remove the tumor from the patient; (2) then the tumor tissue is transported to under sterile, cold chain conditions The laboratory uses mechanical treatment and enzymatic digestion methods to separate tumor infiltrating lymphocytes from the tumor, and isolate the initial tumor infiltrating lymphocytes; (3) Add high-dose IL-2 in vitro culture and transformation to infiltrate the initial tumor The lymphocytes were expanded ten thousand times and further purified, and then frozen; (4) Finally, the tumor-infiltrating lymphocytes were returned to the body of the cholangiocarcinoma patient, and the average amount of tumor-infiltrating lymphocytes per injection was 1×10 11 One.

[0013] Improvement case: A 42-year-old pat...

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Abstract

The invention discloses a method for improving bile duct cancer through TIL immune cells. The method comprises the following specific operation steps: firstly, excising tumors from the body of a patient; then transporting the tumor tissues to a laboratory under sterile and cold-chain conditions, locally separating tumor infiltrating lymphocytes from the tumor by using a mechanical treatment and enzyme digestion method, and separating to obtain initial tumor infiltrating lymphocytes; adding high-dose IL-2 for in-vitro culture and transformation, amplifying the initial tumor infiltration lymphocytes by ten thousand times, further purifying, and performing cryopreservation; and finally, transfusing the tumor infiltrating lymphocytes back into the body of the biliary duct cancer patient, wherein the average quantity of cells injected with the tumor infiltrating lymphocytes each time is 1 * 10<11>. The TIL cells are known immune cells capable of specifically recognizing and attacking cancers. Compared with other immunotherapy, the TIL immune cell therapy has the following advantages: tumor antigen recognition targets are many, side effects are few, many solid tumors can be treated, andthe curative effect is high.

Description

Technical field [0001] The invention belongs to the technical field of immune cell therapy, and specifically is a method for improving cholangiocarcinoma through TIL immune cells. Background technique [0002] Tumor is a type of cell disease. Its basic characteristics are abnormal cell growth and differentiation. Since most tumors are of monoclonal origin, the malignant behavior of tumor cells can be passed on to progeny cells through cell proliferation, which indicates that tumors are Diseases involving changes in the structure and / or function of genetic material DNA. At present, it is generally believed that most of the causes of tumors are caused by the interaction of environmental factors and genetic factors. Environmental factors include cigarettes, alcohol, dietary ingredients, environmental pollutants, drugs, radiation, and sources of infection. Although environmental factors are the initiating factors for tumors, individual factors such as genetic characteristics, age, g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/17A61K35/13A61P35/00
CPCA61K35/13A61K35/17A61P35/00A61K2300/00
Inventor 李军
Owner 卡替(上海)细胞生物技术有限公司
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