Lyophilization container and method of using same

A container, freeze-drying technology, applied in the direction of seals with freeze-drying, medical containers, drying, etc.

Pending Publication Date: 2020-06-16
泰尔茂比司特生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Thus, despite the dominance of traditional methods, there are still disadvantages, especially related to blood that requires long-term storage or requires temperature-controlled transport over long distances.

Method used

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  • Lyophilization container and method of using same
  • Lyophilization container and method of using same
  • Lyophilization container and method of using same

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Embodiment Construction

[0024] A further understanding of the principles described herein may be obtained by reference to the following detailed description and the embodiments depicted in the accompanying drawings. Although specific features are shown and described below with reference to particular embodiments, the application is not limited to the specific features or embodiments presented. Furthermore, the following embodiments may be described with respect to freeze-drying or storing human or animal blood or blood components; however, such descriptions are merely illustrative. Those skilled in the art will appreciate that embodiments of the present disclosure may be used in conjunction with lyophilization of any suitable liquid.

[0025] Embodiments of the present application relate to closed sterile containers that include sterile fluid paths for lyophilization and storage of fluids, thereby avoiding the need for clean rooms. Furthermore, the embodiments described herein can be practiced in co...

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Abstract

Provided is a multi-part lyophilization container (200) for lyophilizing a fluid, such as blood or blood components. The container includes a non-breathable section (202) including a port region (204), a breathable section (206) including a membrane (210), and an occlusion zone (216) encompassing a boundary between the two sections. The non-breathable section is configured to accommodate any of aliquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas. A method of lyophilizing includes creating a temporary seal between the two sections, e.g. by manual clamping in the occlusion zone, inputting a liquid into the non-breathable section, freezing the liquid, removing the temporary seal to allow vapor transport between the two sections, andapplying heat energy under vacuum. The container may then again be occluded in the occlusion zone, a permanent seam created, the container divided at the permanent seam and the breathable section discarded.

Description

[0001] This application claims U.S. Provisional Patent Application No. 62 / 569,858, filed October 9, 2017, in the U.S. Patent and Trademark Office, entitled "Lyophilization and Storage Containers for Freeze-Dried Blood Products," and filed on October 9, 2017. Priority to each of U.S. Provisional Patent Application No. 62 / 571,087, entitled "Lyophilization and Storage Containers for Freeze-Dried Blood Products," filed in the U.S. Patent and Trademark Office on Each of the patent applications is hereby incorporated by reference in its entirety. [0002] This invention was made with Government support under Grant No. H92222-16-C-0081 awarded by the United States Department of Defense. The government has certain rights in this invention. technical field [0003] This application describes apparatus and associated methods for lyophilization (freeze drying) and storage of fluids. The device is an evolving multi-segment lyophilization container that evolves through the stages of fill...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02A61J1/10F26B5/06
CPCA01N1/0263A01N1/0284A01N1/0289A61J1/2093F26B25/063F26B5/06A61J1/10B65D51/241A61J1/1468
Inventor 柯克·L·韦默奈特·T·约翰逊丹尼斯·J·赫拉文卡科斯塔斯·P·帕拉基宁卡斯
Owner 泰尔茂比司特生物技术有限公司
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