52results about "Closures with freeze-drying" patented technology

Improved cap assemblies which isolate materials in containers, e.g., bottles, vials, multi-vial trays, multi-well trays, etc., during processes while permitting vapor to pass into or out of the container, such as during freeze drying and the like, and facilitate subsequent closure of the container to cease such vapor passage (e.g., stoppering, etc.). The cap assembly optimizes containment of solute, prevents contamination, is easy to use and is readily compatible with validated industrial drying processes.

The closure device (500) comprises a stopper (501) made of elastomer and a cover (502) suitable for covering both the neck (12) of a container and stopper (501) in place in said neck (12). The cover (502) is made of plastics material and comprises a ring (503) and a drive member (504). The ring (503) may surround the stopper (501) and the neck (12) in the mounted configuration, the ring being provided with locking means (503G) for locking on the neck (12). The drive member (504) may be mounted on the ring (503) in arbitrary angular orientation about a central axis (X503) of the ring. The drive member is provided with an annular edge (505D) suitable for being engaged between an outer skirt (503A) of the ring (503) and at least one tab (503G) forming locking means and extending radially towards the central axis (X503) of the ring from the skirt (503A).

A container is provided that realizes efficient freeze-drying while preventing contamination during freeze-drying. This freeze-drying container uses a nonporous moisture-permeable film in at least a portion thereof, and the nonporous moisture-permeable film can be formed from a polyurethane or a polyester elastomer.

Embodiments of the present invention include a specimen enclosure apparatus. The specimen enclosure apparatus includes a container having a cavity configured to receive the specimen and an opening extending through a neck of the container to the cavity. An internal flange is positioned intermediate the neck of the container. The specimen enclosure apparatus further includes a closure device configured to be received in the opening. The closure device has a flange seal portion configured to contact the internal flange to form a flange seal proximate the cavity and further has a radial travel limiter integrally formed with the closure device that is configured to contact the container in the opening to limit radial movement of the flange seal portion relative to the internal flange. Containers and closure devices are also provided.

Improved cap assemblies which isolate materials in containers, e.g., bottles, vials, multi-vial trays, multi-well trays, etc., during processes while permitting vapor to pass into or out of the container, such as during freeze drying and the like, and facilitate subsequent closure of the container to cease such vapor passage (e.g., stoppering, etc.). The cap assembly optimizes containment of solute, prevents contamination, is easy to use and is readily compatible with validated industrial drying processes.

Disclosed is a process for the treatment or processing of containers that serve for storing, or contain, substances for medical, pharmaceutical or cosmetic applications, wherein the containers are conveyed automatically, by a conveyor, past at least one processing station or pass it for the treatment or processing. In the process, a plurality of containers is conveyed by the conveyor while being held by a carrier in a regular arrangement. The containers held on the carrier are raised to a raised position for the treatment or processing at or in the respective processing station and are lowered after the treatment or processing, to be held again on the carrier in the regular arrangement. The carrier is configured such that the containers can be held on the carrier during the entire process. A negative pressure acts on the bottoms of the containers in order to lower them.

A capping system and method of use for sealing injectable drugs within vials is disclosed. The system includes a closure assembly and a locking cap. The closure assembly includes a retainer member and a resilient stopper located within the retainer member. The retainer member is arranged to be disposed on the vial whereupon a gap results between the stopper and the vial. The retainer member is movable to close that gap. The locking cap is used to permanently seal the vial.

A closure for dispensing one or more active agents into a container comprises a sealed or sealable chamber having a breakable wall and a hollow piston slidably mounted in a piston guide. Said hollow piston comprises an outer wall having an end in the chamber and at least one ventilation aperture. Said end has a cutting formation. Said hollow piston is slidable in the piston guide between a ventilation position in which the at least one ventilation aperture allows ventilation of the chamber and a sealed position in which the at least one ventilation aperture is sealed to prevent ventilation of the chamber and a deployed position in which the cutting formation has broken through at least a portion of the breakable wall. The outer wall has a retaining formation which engages with the piston guide to releasably resist sliding of the hollow piston between the ventilation position and the sealed position and the deployed position. The hollow piston may have an outer wall, and said outer wall has an end within the chamber, facing the breakable wall, wherein the cutting end has a first edge having a cutting formation and a gap in said cutting formation.

A method for lyophilizing a substance is provided which may include placing at least one vial containing the substance in a lyophilization chamber, the at least one vial having an opening in which a stopper is inserted in a closed state not allowing gas exchange between the interior and exterior of the vial; providing mechanical means external to the stopper and arranged at the opening for restricting an upward movement of the stopper; lowering the temperature within the lyophilization chamber to a predefined value below the freezing temperature of the substance and reducing the pressure within the lyophilization chamber to a predefined pressure at a predefined temperature, the predefined pressure being chosen such that the force exerted by it on the stopper lifts the stopper from the closed state to an exchange state in which the stopper is only partly inserted in the opening of the vial allowing gas exchange between the interior and exterior of the vial, wherein the lowering of the temperature within the lyophilization chamber to the predefined value is performed before reducing the pressure within the lyophilization chamber to the predefined pressure and wherein lifting the stopper from the closed state abruptly lowers the pressure within the at least one vial which initiates nucleation in the substance within that vial. In addition, mechanical means is provided which may be used in order to perform the method for lyophilizing a substance.

Embodiments of the present invention include a specimen enclosure apparatus. The specimen enclosure apparatus includes a container having a cavity configured to receive the specimen and an opening extending through a neck of the container to the cavity. An internal flange is positioned intermediate the neck of the container. The specimen enclosure apparatus further includes a closure device configured to be received in the opening. The closure device has a flange seal portion configured to contact the internal flange to form a flange seal proximate the cavity and further has a radial travel limiter integrally formed with the closure device that is configured to contact the container in the opening to limit radial movement of the flange seal portion relative to the internal flange. Containers and closure devices are also provided.

The invention relates to containers for the drying, especially the freeze-drying, of material. In particular, the invention relates to a lid of a drying container, said lid enabling to close the container body of the drying container so as to avoid i) contamination of the material to be dried inside the container and ii) spills of airborne solid particles of said material from the container to the environment. The lid comprises a lower and an upper frame with a vapor permeable sheet positioned in between. The invention further provides methods for the drying, especially the freeze-drying, of material.

A method for lyophilizing a substance is provided which may include placing at least one vial containing the substance in a lyophilization chamber, the at least one vial having an opening in which a stopper is inserted in a closed state not allowing gas exchange between the interior and exterior of the vial; providing mechanical means external to the stopper and arranged at the opening for restricting an upward movement of the stopper; lowering the temperature within the lyophilization chamber to a predefined value below the freezing temperature of the substance and reducing the pressure within the lyophilization chamber to a predefined pressure at a predefined temperature, the predefined pressure being chosen such that the force exerted by it on the stopper lifts the stopper from the closed state to an exchange state in which the stopper is only partly inserted in the opening of the vial allowing gas exchange between the interior and exterior of the vial, wherein the lowering of the temperature within the lyophilization chamber to the predefined value is performed before reducing the pressure within the lyophilization chamber to the predefined pressure and wherein lifting the stopper from the closed state abruptly lowers the pressure within the at least one vial which initiates nucleation in the substance within that vial. In addition, mechanical means is provided which may be used in order to perform the method for lyophilizing a substance.

A stopping device, comprising a stopper and a plastic cap to cover a container's neck with the stopper in the neck, the cap comprising a cover and a ring surrounding the stopper and the neck when mounted onto the neck, the ring and cover being produced as a single component connected by at least one part breakable by a force parallel to a central axis of the ring directed towards the stopper, the cover having an element resting against the stopper, the breakable part having bridges extending between an outer radial edge of the cover and an inner radial edge of the ring, and a channel in an arc of a circle defined between two adjacent bridges, the length of the cover's outer radial edge and the length of the rings inner radial edge, the channel having radial width smaller than 0.3 mm and axial height more than 0.15 mm.

A stopping device for a container, comprising a circular stopper for closing the neck of the container, and a cap comprising a synthetic material that covers the neck and the stopper positioned in the neck, the cap comprising a cover and a ring for surrounding the stopper and the neck, the ring having a minimum inner diameter larger than the maximum diameter of the stopper, the ring and the cover being produced as a single component and connected by breakable bridges distributed over a circumference of the ring with an inner diameter that is larger than or equal to the maximum diameter of the stopper, and first locking tabs formed on the inside of the ring facing windows that are radially open towards the outside, and second locking tabs facing a closed part, each second tab formed between two first tabs, facing a strip of material separating windows.

The invention relates to a stopping device (20) for a container (1) with a neck (12), said device comprising a stopper (21) and a plastic cap (24) that can cover both the neck and the stopper positioned in the neck. The cap (24) comprises a cover (26) and a ring (25) that is suitable for surrounding the stopper (21) and the neck (12) when mounted and provided with means (253) for locking onto the neck. The ring (25) and the cover (26) are produced as a single component and are connected by at least one part that is breakable by means of a force parallel to a central axis (X25) of the ring and directed towards the stopper (21). The cover (26) is provided with an element (262) for resting against the stopper (21). The breakable part consists of bridges (27) extending radially between an outer radial edge (261) of the cover (26) and an inner radial edge (257) of the ring (25). A channel (28) in an arc of a circle is defined between two adjacent bridges (27), the length of the outer radial edge (261) of the cover and the length of the inner radial edge (257) of the ring. Said channel has a radial width (28) of less than 0.3 mm and an axial height (H28) of more than 0.15 mm.

The invention discloses a high-sealing-performance vaccine glass bottle, and belongs to the technical field of vaccine glass bottles. An embedding part and an elastic sealing bag which are matched with each other are additionally arranged, during installation, gas is guided into a refrigeration cavity through a gas pipe, the gas is pressed into a gas guide cavity through a circulation hole, the elastic sealing bag and a magnetic extrusion part are synchronously expanded outwards under gas extrusion, the magnetic extrusion part plays an elastic supporting role on the elastic sealing bag, meanwhile, a magnetic attraction layer is used for carrying out magnetic attraction on an elastic magnetic ring, so that the elastic sealing bag is attached to a sealing gasket, the sealing performance of the joint of the elastic sealing bag and the sealing gasket is improved, the stability of the concave connection between a bottle plug and the embedding part is improved, the bottle plug is not prone to being separated from a bottle opening, a semiconductor refrigeration piece is used for refrigeration, and the circulating gas flow is used for low-temperature transmission in the bottle body, so that a low-temperature environment is provided for the vaccine; and in addition, when the refrigeration environment of the bottle body is damaged, the thermal expansion gas in an early warning pipe is thermally expanded to extrude and trigger a contact piece type high-temperature early warning piece, so that high-temperature early warning is realized.

A pre-loaded container and a method of manufacturing a pre-loaded vial is provided wherein one or more active agents is lyophilised within the vial cap and the vial cap is then sealed onto a vial retaining a suitable diluent to form the pre-loaded vial. Lyophilising the one or more active agents within the vial cap ensures that the one or more active agents are retained in sterile conditions, that the lyophilised one or more active agents and the diluent may be stored efficiently, and that the one or more active agents may be solubilised in a sterile and efficient manner.

Provided is a multi-part lyophilization container (200) for lyophilizing a fluid, such as blood or blood components. The container includes a non-breathable section (202) including a port region (204), a breathable section (206) including a membrane (210), and an occlusion zone (216) encompassing a boundary between the two sections. The non-breathable section is configured to accommodate any of aliquid, a solid, a gas or combination thereof. The breathable section is configured to accommodate only a gas. A method of lyophilizing includes creating a temporary seal between the two sections, e.g. by manual clamping in the occlusion zone, inputting a liquid into the non-breathable section, freezing the liquid, removing the temporary seal to allow vapor transport between the two sections, andapplying heat energy under vacuum. The container may then again be occluded in the occlusion zone, a permanent seam created, the container divided at the permanent seam and the breathable section discarded.

The invention discloses a high-protectiveness inner box of a packing box for an ampoule bottle. The inner box comprises an inner box body; the inner box body is rotationally connected with an inner box cover through a connecting a hinge; eight ampoule bottle grooves are formed in a foam vibration reducing layer on the inner box body at equal intervals; fixed grooves are formed in the outer side frame of the inner box body; positioning grooves are symmetrically formed in two side frames of the inner box body; and eight ampoule bottle caps connected with the ampoule bottle grooves are welded on the inner box cover at equal intervals. In the inner box, a rubber extension spring is firstly provided; the rubber extension spring is connected with a cushion block to extrude the ampoule bottle; and two bottleneck pressing blocks can fix the bottleneck of the ampoule bottle in the ampoule bottle grooves from two sides, so that the ampoule bottle is fixed in all directions, the fixation of the ampoule bottle is firmer, and the quality of the inner box of the packing box for the ampoule bottle is improved.

A stopping device for a container, comprising a circular stopper for closing the neck of the container, and a cap comprising a synthetic material that covers the neck and the stopper positioned in the neck, the cap comprising a cover and a ring for surrounding the stopper and the neck, the ring having a minimum inner diameter larger than the maximum diameter of the stopper, the ring and the cover being produced as a single component and connected by breakable bridges distributed over a circumference of the ring with an inner diameter that is larger than or equal to the maximum diameter of the stopper, and first locking tabs formed on the inside of the ring facing windows that are radially open towards the outside, and second locking tabs facing a closed part, each second tab formed between two first tabs, facing a strip of material separating windows.

A closure for dispensing one or more active agents into a container comprises a sealed or sealable chamber having a breakable wall and a hollow piston slidably mounted in a piston guide. Said hollow piston comprises an outer wall having an end in the chamber and at least one ventilation aperture. Said end has a cutting formation. Said hollow piston is slidable in the piston guide between a ventilation position in which the at least one ventilation aperture allows ventilation of the chamber and a sealed position in which the at least one ventilation aperture is sealed to prevent ventilation of the chamber and a deployed position in which the cutting formation has broken through at least a portion of the breakable wall. The outer wall has a retaining formation which engages with the piston guide to releasably resist sliding of the hollow piston between the ventilation position and the sealed position and the deployed position. The hollow piston may have an outer wall, and said outer wall has an end within the chamber, facing the breakable wall, wherein the cutting end has a first edge having a cutting formation and a gap in said cutting formation.

The invention relates to containers for the drying, especially the freeze-drying, of material. In particular, the invention relates to a lid of a drying container, said lid enabling to close the container body of the drying container so as to avoid i) contamination of the material to be dried inside the container and ii) spills of airborne solid particles of said material from the container to the environment. The lid comprises a lower and an upper frame with a vapor permeable sheet positioned in between. The invention further provides methods for the drying, especially the freeze-drying, of material.

The invention discloses a heat preservation box. The heat preservation box comprises box bodies and cover bodies. The box bodies are provided with storage cavities; the upper portions of the box bodies are provided with openings communicating with the storage cavities; the outer outline sizes of the box bodies gradually increase from the bottoms to the upper portions of the box bodies; and the outline sizes of the storage cavities of the box bodies gradually increase from the bottoms to the upper portions of the storage cavities. Refrigerating devices are arranged in the cover bodies; and thecover bodies are matched and detachably connected with the box bodies. When the cover bodies are covered on openings of the box bodies, the openings of the box bodies are sealed by the cover bodies, and the refrigerating devices are used for adjusting the temperatures of the storage cavities in the box bodies. When the heat preservation box is not in use, the box bodies and the cover bodies can beseparated and stored, the plurality of box bodies can be nested and stacked in sequence and stored, the required space is small, and storage can be conveniently carried out; and refrigeration is carried out through the box covers, so that the refrigeration devices can be prevented from being damaged when the plurality of box bodies are stacked.

A stopper for a container for use in freeze-drying processes, and an assembly of a stopper and a container are provided. The stopper has an insertion section configured for insertion into the container. The insertion section has a sealing section for closing the container in a fluid-tight manner in a sealing position of the stopper and a contact section which adjoins the sealing section axially from a top surface in the direction of a bottom surface, for holding the stopper in a drying position of the stopper. The contact section has at least one passage opening for a gas exchange between an interior of the container and the surroundings of the container. The stopper has a sealing body and a main body connected together, wherein the main body consists of a material which has a higher degree of hardness than a material which makes up the sealing body. Regions of a lateral surface of the insertion section in contact with an inner surface of a container wall in the drying position and / or the sealing position, are formed by outer surfaces of the sealing body in the region of the contact section, wherein the main body is configured within the sealing body in the region of the contact section.

The invention provides an anti-collision buffering raw material barrel which comprises a barrel body and a barrel cover. The barrel cover is fixed to the barrel body through a hinge arranged on the outer side of the barrel cover, the top edge of the barrel body is provided with a boss in a stretching mode, a sealing gasket is arranged between the barrel body and the barrel cover, and a drying device is arranged at the center of the sealing gasket; a plurality of anti-collision barriers are arranged on the outer side of the barrel body, the bottom of the barrel body is shaped like a taper, the boss stretching out of the top edge of the barrel body is a whole circular boss, a threaded hole is formed in the center of the bottom of the barrel body and is in threaded connection with a bolt, the 36 anti-collision barriers are arranged on the outer side of the barrel body and made of stainless steel, and the drying device can be replaced with a cooling device. The anti-collision buffering raw material barrel is convenient to use, simple in structure and high in practicability, the problem that in the transporting and using process of the raw material barrel, abrasion is generated due to improper operation is solved, the service life of the raw material barrel is prolonged, and the anti-collision capacity and the repeatable recycling utilization rate are high.

The invention discloses a beverage bottle cap with self-cooling device and a beverage bottle thereof, wherein the beverage bottle cap comprises an annular cover body, a top cover and a self-cooling device; the top cover is provided with a ventilation hole I, a ventilation hole II and a straw hole which penetrate through the top surface of the top cover; the self-cooling device comprises a fan-shaped sealing plate, a three-way control valve, a refrigerant storage container, a refrigerant output pipe and an elastic suction pipe. The beverage bottle cap with the self-cooling device adopts the waythat the control valve core of the three-way control valve is driven by the rotary fan-shaped sealing plate, in the state of self-cooling, on the one hand the beverage bottle body can achieve internal and external connection through the ventilation hole I, and on the other hand the bottom of the liquid level of the beverage entering the beverage bottle body can be heat-absorbed and vaporized, andthe temperature of the beverage is reduced; in the state of drinking, on the one hand the beverage bottle body can achieve internal and external connection through the ventilation hole II, and on theother hand directly drinking can be achieved without opening the bottle cap, resolving the problem that the refrigerant accelerates to evaporate, which is particularly suitable for containing the antipyretic beverage in summer.