Application of pentamethine cyanine dye Cy5-671 in preparation of antitumor drugs

A technology of anti-tumor drugs and compounds, which is applied in the application field of the new Wujiachuan cyanine dye Cy5-671 in the preparation of anti-tumor drugs to achieve the effect of inhibition

Active Publication Date: 2020-08-07
HENAN UNIVERSITY
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The application of Cy5-671 in the preparation of anti-tumor drugs is based on the research of th

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  • Application of pentamethine cyanine dye Cy5-671 in preparation of antitumor drugs
  • Application of pentamethine cyanine dye Cy5-671 in preparation of antitumor drugs
  • Application of pentamethine cyanine dye Cy5-671 in preparation of antitumor drugs

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[0022] In order to make the technical objectives, technical solutions and beneficial effects of the present invention clearer, the technical solutions of the present invention will be further described below in conjunction with specific embodiments, but the implementations are intended to explain the present invention and should not be construed as limiting the present invention. If specific techniques or conditions are not indicated in the examples, the procedures shall be carried out in accordance with the techniques or conditions described in the literature in the field or in accordance with the product specification.

[0023] experimental method:

[0024] Compound preparation: Cy5-671 was dissolved in the culture medium and prepared into 1mM stock solution for later use. Cy5-671 structure identification 1 HNMR(A) see figure 1 -A, HRMS(B) data see figure 1 -B.

[0025] 1. MTT method was used to determine the inhibitory effect of Cy5-671 on the cell viability of colorectal cancer c...

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Abstract

The invention belongs to the field of chemical medicine, and relates to application of 1-[N-(3,5-bis(2-(2-methoxyethoxy)ethoxy)ethoxy)benzyl-2,3,3-trimethyl-5-sulfo-3H-indole]-5-[N-carboxybenzyl-2,3,3-trimethyl-5-sulfo-3H-indole]-5-pentacyaninebromide dye (Cy5-671 as hereinafter referred to preparation) for preparing an anti-tumor medicine. MTT results show that Cy5-671 can significantly inhibit the cell viability of colorectal cancer cell lines HCT116 and SW480. Animal experiment results show that Cy5-671 significantly inhibits the growth of human colorectal cancer cell line HCT116 BALB/C nude mouse subcutaneous tumor-bearing, and can be used for preparing antitumor drugs. The Cy5-671 disclosed by the invention can be developed as a novel anti-tumor drug or an auxiliary component thereof,so that the tumor inhibition effect is remarkable, and a new treatment way and means are provided for tumor treatment.

Description

technical field [0001] The invention belongs to the technical field of chemical industry and medicine, and in particular relates to the application of a novel Wujiachuan cyanine dye Cy5-671 in the preparation of antitumor drugs. Background technique [0002] Malignant tumors are one of the most important causes of death and the biggest obstacle to prolonging human life in the 21st century. In recent years, with the transformation of people's lifestyle and dietary structure, the incidence and mortality of tumors worldwide are on the rise, and the age of onset is younger. Although the prognosis of malignant tumor patients has been greatly improved with the application of new technologies in diagnosis and treatment and the continuous updating of chemotherapy drugs, the overall survival rate of patients has not been significantly improved. So far, although there are many methods for the treatment of malignant tumors, surgery and chemotherapy are still the main treatments. Surg...

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Application Information

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IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0052A61K41/0057A61P35/00
Inventor 张付利邱娜王群邹娅欣刘芳艳史霄张磊贾爽爽李娜王春丽李思颖
Owner HENAN UNIVERSITY
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