Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (CSCS) by inhibiting mitochondrial respiration
A Mitochondrial, Cancer Cell Technology Applied to Mitoflavoscin: Enzymes Containing Targeted Flavin Eliminate Cancer Stem Cell (CSCS) Field by Inhibiting Mitochondrial Respiration, Addressing Difficulty in Identifying Primary Driver Mutations Across Cancer Subtypes
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[0026] The following description shows embodiments of the approach in sufficient detail to enable the practice of the approach. Although the present approach has been described with reference to these specific embodiments, it should be understood that the present approach can be embodied in different forms, and that this description should not be construed to limit any appended claims to the specific embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the approach to those skilled in the art.
[0027] Mitochondrial metabolism is an untapped pathway for the treatment of a variety of afflictions ranging from cancer to bacterial and fungal infections to aging. Functional mitochondria are required for cancer stem cell proliferation. Inhibiting mitochondrial metabolism in cancer cells prevents the proliferation of those cells. This pathway explores this pathway by screening ...
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