Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (CSCS) by inhibiting mitochondrial respiration

A Mitochondrial, Cancer Cell Technology Applied to Mitoflavoscin: Enzymes Containing Targeted Flavin Eliminate Cancer Stem Cell (CSCS) Field by Inhibiting Mitochondrial Respiration, Addressing Difficulty in Identifying Primary Driver Mutations Across Cancer Subtypes

Pending Publication Date: 2020-08-21
LUNELLA BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite knowledge of the genomic landscape, modern oncology stru

Method used

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  • Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (CSCS) by inhibiting mitochondrial respiration
  • Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (CSCS) by inhibiting mitochondrial respiration
  • Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (CSCS) by inhibiting mitochondrial respiration

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Embodiment Construction

[0026] The following description shows embodiments of the approach in sufficient detail to enable the practice of the approach. Although the present approach has been described with reference to these specific embodiments, it should be understood that the present approach can be embodied in different forms, and that this description should not be construed to limit any appended claims to the specific embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the approach to those skilled in the art.

[0027] Mitochondrial metabolism is an untapped pathway for the treatment of a variety of afflictions ranging from cancer to bacterial and fungal infections to aging. Functional mitochondria are required for cancer stem cell proliferation. Inhibiting mitochondrial metabolism in cancer cells prevents the proliferation of those cells. This pathway explores this pathway by screening ...

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Abstract

The present disclosure relates to compounds that bind to flavin-containing enzymes and inhibit mitochondrial function, referred to herein as mitoflavoscins. Methods of screening compounds for mitochondrial inhibition and anti-cancer properties are disclosed. Also described are methods of using mitoflavoscins to prevent or treat cancer, bacterial infections, and pathogenic yeast, as well as methodsof using mitoflavoscins to provide anti-aging benefits. Specific mitoflavoscin compounds are also disclosed.

Description

technical field [0001] The present disclosure relates to a compound that binds to a flavin-containing enzyme and inhibits mitochondrial function, "mitoflavoscin," and includes methods of synthesizing mitoflavoscin, methods of using mitoflavoscin to target cancer stem cells, and methods for treating cancer and reducing drug resistance of cancer cells Pharmaceutical compounds, pharmaceutical compositions containing one or more mitoflavoscins as active ingredients. "mitoflavin" - a compound that is a derivative of riboflavin that inhibits mitochondrial function - is also disclosed. Background technique [0002] Researchers strive to develop new anticancer treatments. Conventional cancer therapies (e.g. radiation; alkylating agents such as cyclophosphamide; and antimetabolites such as 5-fluorouracil) have attempted to selectively detect and eradicate rapidly growing cancer cell. Other cancer therapies use immunotherapies (such as monoclonal antibodies) that selectively bind t...

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Application Information

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IPC IPC(8): A61K31/03A61K33/18C07C25/18C07C25/22
CPCA61K31/03C07C25/18A61P35/00A61K31/201C07D475/14C07D347/00A61K31/66A61N5/062A61K31/14A61K45/06G01N33/5079A61K33/18A61P43/00A61P31/04A61K31/155A61K31/20A61K31/525
Inventor M·P·利桑蒂F·苏特加
Owner LUNELLA BIOTECH INC
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