Ligand modified myricetin liposome particle size control device

Abstract

The invention provides a ligand modified myricetin liposome particle size control device which comprises a reactor. An air suction cylinder fixedly is connected to the right side of a support, a rackplate is fixedly connected to the right side of a piston rod, an incomplete gear is rotationally mounted on the inner top wall of the support, a limiting part corresponding to the incomplete gear is movably inserted into the left side of a rotating cylinder, the top of a lifting plate is connected with the incomplete gear and the rotating cylinder through a driving assembly, and a steel wire ropeinserted into the reactor is fixed to the inner top wall of the support. In the crushing process, a solution continuously oscillates, so that the steel wire rope shakes, the steel wire rope drives thelifting plate to do reciprocating motion through a movable plate, the piston rod does reciprocating motion under pulling of the incomplete gear and a tension spring, foam generated during ultrasoniccrushing is sucked into a collecting box through an air suction cylinder, the foam is prevented from affecting the crushing power, and the size uniformity of myricetin liposome particles subjected toultrasonic crushing is further ensured.

Description

technical field [0001] The invention belongs to the technical field of myricetin liposome preparation, in particular to a ligand-modified myricetin liposome particle size control device. Background technique [0002] Myricetin, also known as myricetin, is widely found in a variety of natural plants and has a wide range of pharmacological activities. It also has anti-inflammatory, anti-tumor, analgesic, liver-protecting and hypoglycemic effects. Anti-oxidation and cholesterol-lowering effects can be added to cosmetics as antioxidants, and can also be used as health products. Therefore, myricetin has good development and application potential. [0003] The preparation process of ligand-modified myricetin liposomes is as follows: Weigh soybean lecithin, cholesterol, myricetin and DSPE-PEG2000-RGD, add absolute ethanol to fully dissolve the four, then evaporate to form a film, add PBS solution to dissolve , so that the membrane is dissolved and dispersed and fully hydrated, ult...

AI Technical Summary

Problems solved by technology

[0003] The preparation process of ligand-modified myricetin liposomes is as follows: Weigh soybean lecithin, cholesterol, myricetin and DSPE-PEG2000-RGD, add absolute ethanol to fully dissolve the four, then evaporate to form a film, add PBS solution to dissolve , so that the membrane is dissolved and dispersed and fully hydrated, ultrasonically broken by a cell ultrasonic breaker, filtered through a microporous membrane, and finally formed RGD peptide-modified myricetin liposomes, which will produce a large amount of foam when ultrasonically broken. It affects the crushing power, and finally leads to incomplete crushing, and the particle size of myricetin liposomes varies

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