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Sodium chlorite compositions with enhanced Anti-microbial efficacy and reduced toxicity

A technology of sodium chlorite and antibacterial composition, which can be used in pharmaceutical combinations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve problems such as loss, eye discomfort, vision, etc.

Pending Publication Date: 2021-01-26
ALLERGAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, povidone-iodine is an irritant, especially when applied to the surface of the eye, and povidone-iodine can cause eye discomfort and loss of vision

Method used

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  • Sodium chlorite compositions with enhanced Anti-microbial efficacy and reduced toxicity
  • Sodium chlorite compositions with enhanced Anti-microbial efficacy and reduced toxicity
  • Sodium chlorite compositions with enhanced Anti-microbial efficacy and reduced toxicity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Antimicrobial Efficacy of Sodium Chlorite Compositions Compared to 5% Povidone-Iodine

[0070] A time kill efficacy experiment was performed against Staphylococcus aureus ATCC 29213 (Saureus). Plates with Tryptic Soy Agar (TSA) were inoculated with a culture of Saureus and incubated at 30°C to 35°C for 24 hours. Harvest the bacterial culture and adjust the sample suspension to contain approximately 10 5 to 10 6 Colony forming units (CFU). For each test, 10 mL of the test article ( 5% sterile ophthalmic preparation solution (povidone-iodine ophthalmic solution; Alcon, Fort Worth, TX) or sodium chlorite) was dispensed into sterile glass test tubes, inoculated with 100 μL of Saureus suspension and mixed thoroughly . Sodium chlorite was activated with one of four pH varying buffers (pH 5, pH 4, pH 3 or pH 2) for 30 seconds up to 5 minutes and then dispensed. After 30 seconds of exposure, 1 mL of the test suspension was removed and Dey-Engley neutralizer was added to ...

Embodiment 2

[0078] Ocular Safety and Tolerability of Sodium Chlorite Compositions Compared with Povidone-iodine 5%

[0079] Ocular safety and tolerability experiments were performed in non-sedated rabbits and included 1) assessment of corneal staining with topical sodium fluorescein, which is a readout for epithelial integrity), 2) ocular surface hyperemia Assessment (which is a reading of irritation) and 3) visual acuity assessment (which is a reading of how visual performance is affected by corneal damage).

[0080] Corneal epithelial integrity was assessed according to the NEI corneal staining guidelines for dry eye (Lemp MA. Report of the National Eye Institute / Industry workshop on Clinical Trials in DryEyes. CLAO J. 1995; 21:221–232). Rabbits were divided into 4 treatment groups: 5% povidone-iodine (n=8), sodium chlorite 8000 ppm formulation pH 3 (n=8), pH 4 (n=8) and pH 5 (n=4), And before administration with 250 ul of the test formulation, it was treated unilaterally with a drop o...

Embodiment approach P1

[0092] Embodiment P1. An antimicrobial composition for disinfecting tissue, wherein the composition comprises sodium chlorite.

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Abstract

Disclosed are antiseptic compositions for disinfecting tissues, in particular for ocular use. Methods and compositions disclosed herein include sodium chlorite, optionally in combination with a surfactant.

Description

[0001] Priority Document Citation [0002] This application claims the benefit of priority under 35 U.S.C. §119(e) to pending U.S. Provisional Patent Application No. 62 / 663,886, filed April 27, 2018. The disclosure of this provisional patent application is incorporated herein by reference in its entirety. Background technique [0003] The most common type of skin antisepsis used in surgery is the The povidone-iodine was prepared. Povidone-iodine is an effective antimicrobial agent against many types of organisms in various environments such as the skin, in wounds and on the surface of the eye. However, povidone-iodine is an irritant, especially when applied to the ocular surface, and povidone-iodine can cause eye discomfort and loss of vision. Contents of the invention [0004] Embodiments disclosed herein include antimicrobial compositions for disinfecting tissue comprising sodium chlorite. The amount of sodium chlorite can be from about 800 ppm to about 8000 ppm. Sod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61Q17/00A61K9/00A61K8/19A61K33/00A61P31/04
CPCA61K8/19A61K8/4993A61K8/86A61K9/0048A61K33/00A61P31/04A61Q17/005A61K47/02A61K47/26A61K47/10A61K47/12A61P27/00A01N59/00A01N25/02A01N25/04A61P31/02A61K9/0014
Inventor 詹姆斯·A·伯克理查德·S·格雷厄姆科里内·戈森亚历山德拉·阿尔玛让迈克尔·恩格斯拉克西米·拉贾戈帕兰
Owner ALLERGAN INC
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