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Combined medicine for inhibiting formation of ubiquitous drug-resistant acinetobacter baumannii biofilm

A biofilm, bacteria-inhibiting technology, applied in antibacterial drugs, pharmaceutical formulations, organic active ingredients, etc., can solve the problem of undocumented inhibition, and achieve the effects of reducing virulence, improving inhibition and broad application prospects.

Inactive Publication Date: 2021-04-06
CHENGDU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this document does not record how to improve the inhibitory effect of drugs on the biofilm formation ability of XDRAB and reverse the drug resistance of XDRAB

Method used

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  • Combined medicine for inhibiting formation of ubiquitous drug-resistant acinetobacter baumannii biofilm
  • Combined medicine for inhibiting formation of ubiquitous drug-resistant acinetobacter baumannii biofilm
  • Combined medicine for inhibiting formation of ubiquitous drug-resistant acinetobacter baumannii biofilm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Preparation of combined medicine

[0029] Combination medicines consist of the following two components:

[0030] Component 1: 128 μg / ml baicalin;

[0031] Component 2: 0.0625 μg / ml tigecycline.

Embodiment 2

[0032] Embodiment 2: preparation combined medicine

[0033] Combination medicines consist of the following two components:

[0034] Component 1: 128 μg / ml baicalin;

[0035] Component 2: 0.0317 μg / ml tigecycline.

Embodiment 3

[0036] Embodiment 3: preparation combined medicine

[0037] Combination medicines consist of the following two components:

[0038] Component 1: 128 μg / ml baicalin;

[0039] Component 2: 0.0158 μg / ml tigecycline.

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Abstract

The invention provides a combined medicine for inhibiting formation of a ubiquitous drug-resistant acinetobacter baumannii biofilm. The combined medicine contains baicalin and tigecycline which are prepared from the same or different specification units and used for simultaneous or separate administration, and a pharmaceutically acceptable carrier. Experimental results show that compared with the single use of baicalin or tigecycline, the combined use of baicalin and tigecycline significantly improves the effect of the drug in inhibiting the formation of the XDRAB biofilm. The combined medicine provided by the invention has a remarkably improved effect of inhibiting the formation of an XDRAB biofilm, can reverse the drug resistance of XDRAB and reduce the toxicity of XDRAB, and has a wide application prospect in the preparation of anti-ubiquitous drug-resistant Acinetobacter baumannii medicines and medicines for preventing and treating diseases caused by ubiquitous drug-resistant Acinetobacter baumannii infection.

Description

technical field [0001] The invention belongs to the technical field of microbial medicine, and in particular relates to a combined medicine for inhibiting the biofilm formation of pan-drug-resistant Acinetobacter baumannii. Background technique [0002] Acinetobacter baumannii (Acinetobacter baumannii) is a non-fermentative aerobic Gram-negative opportunistic pathogen; due to the widespread use of antibacterial drugs and the strong ability of Acinetobacter baumannii to acquire drug resistance, it is , Acinetobacter baumannii has developed from drug-resistant bacteria to multi-drug-resistant bacteria, and then to pan-drug-resistant bacteria. Pan-drug-resistant Acinetobacter baumannii (XDRAB) has become an important cause of hospital outbreaks and refractory infections. one of the pathogenic bacteria. [0003] At present, for the treatment of diseases caused by XDRAB infection, the development and marketing of new drugs is slow, and conventional treatment drugs are facing sev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/65A61P31/04
CPCA61K31/65A61K31/7048A61P31/04A61K2300/00
Inventor 凌保东彭勤孟千琳
Owner CHENGDU MEDICAL COLLEGE