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An antibody composition for detecting the therapeutic effect of multiple myeloma, its kit and application

A technology of multiple myeloma and antibody composition, applied in the field of biomedicine, can solve problems such as unseen, and achieve the effects of convenient operation, alleviation of pain, and saving of consumables

Active Publication Date: 2021-06-25
BEIJING JISHUITAN HOSPITAL
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  • Abstract
  • Description
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Problems solved by technology

[0004] The detection of circulating blood tumor cells in patients with multiple myeloma is still in the initial stage of scientific research, and due to the interference of various factors such as the number of cells harvested in different studies, the combination of antibodies used, and the definition of sensitivity, so far So far, we have not seen any relevant reports on the evaluation of the efficacy of this detection technology in place of bone marrow aspiration in the treatment of multiple myeloma

Method used

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  • An antibody composition for detecting the therapeutic effect of multiple myeloma, its kit and application
  • An antibody composition for detecting the therapeutic effect of multiple myeloma, its kit and application

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Embodiment Construction

[0026] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0027] It should be noted that the terms "first" and "second" in the description and claims of the present invention and the above drawings are used to distinguish similar objects, but not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used are interchangeable under appropriate ...

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Abstract

The invention discloses an antibody composition for detecting the therapeutic effect of multiple myeloma, its kit and application. The antibody combination scheme provided by the invention includes a flow-type antibody that has never been clinically used in the detection of peripheral blood tumor plasma cells. Combination, and stipulates the number of cells to be detected, standardized operation steps, and clarifies the degree of sensitivity that needs to be achieved. The use of peripheral blood instead of bone marrow samples can greatly reduce the pain of patients undergoing bone marrow puncture, and the detection of peripheral plasma cells can be repeated, which is flexible and convenient, greatly reducing the workload of clinicians and improving efficiency.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to an antibody composition for detecting the therapeutic effect of multiple myeloma, a kit and application thereof. Background technique [0002] Multiple myeloma is a malignant hematological tumor, and patients cannot be cured, requiring continuous chemotherapy for at least 2 years or even long-term continuous treatment. Patients receiving chemotherapy need to undergo bone marrow aspiration every two months in order to comprehensively evaluate the treatment effect in combination with other indicators. Currently, the internationally recognized indicators for evaluating curative effect include blood immunoglobulin quantification, urine light chain quantification, the proportion of plasma cells in bone marrow aspiration, and imaging examinations. Among them, bone marrow puncture is a kind of invasive examination, which needs to be performed under anesthesia. The patient has certain...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/577G01N33/574G01N33/569G01N15/14
CPCG01N15/14G01N33/56966G01N33/57407G01N33/577G01N2015/149G01N2800/52
Inventor 褚彬鲍立陆敏秋石磊高珊房立娟王宇彤
Owner BEIJING JISHUITAN HOSPITAL
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