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A traditional Chinese medicine compound preparation for treating erbb2 positive gastric cancer and preparation method thereof

A technology of compound preparations and traditional Chinese medicines, which is applied in the direction of medical formulas, medical preparations containing active ingredients, antineoplastic drugs, etc., can solve the problem of no recommended maintenance regimen for gastric cancer, achieve prevention and treatment of ErbB2-positive gastric cancer, and prolong median Survival time, the effect of reducing patient metastasis

Active Publication Date: 2022-04-15
天津中医药大学第一附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] There is no recommended maintenance therapy for gastric cancer in the 2019 edition of the National Comprehensive Cancer Network (NCCN) clinical practice guidelines for gastric cancer and the 2018 edition of the Chinese Society of Clinical Oncology (CSCO) gastric cancer guidelines
[0010] However, there is no effective traditional Chinese medicine compound preparation for the treatment of ErbB2-positive gastric cancer on the market.

Method used

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  • A traditional Chinese medicine compound preparation for treating erbb2 positive gastric cancer and preparation method thereof
  • A traditional Chinese medicine compound preparation for treating erbb2 positive gastric cancer and preparation method thereof
  • A traditional Chinese medicine compound preparation for treating erbb2 positive gastric cancer and preparation method thereof

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Effect test

Embodiment 1

[0049] A traditional Chinese medicine compound preparation for treating ErbB2-positive gastric cancer, comprising the following raw material components in parts by weight: 6 parts of Astragalus membranaceus, 4 parts of Codonopsis pilosula, 3 parts of Atractylodes macrocephala, 3 parts of turmeric, 3 parts of turmeric, 3 parts of fried chicken, bitter Ginseng 4 parts, Hedyotis diffusa 4 parts, Coix seed 3 parts.

[0050] The preparation method of the above-mentioned traditional Chinese medicine compound preparation for treating ErbB2-positive gastric cancer is as follows: S1. Add ethanol to turmeric, curcuma, fried gallinaceae, flavescens, diffusa, coix seed, extract 1-3 times, Extract for 0.5-3 hours each time to obtain extract A, recover the solvent under reduced pressure, concentrate, dry, and pulverize to obtain extract A; S2. Decoct Codonopsis pilosula, Radix Astragali, and Atractylodes macrocephala for 0.5 hours, add 1-40 times the amount of water , heating and extracting...

Embodiment 2

[0052] A traditional Chinese medicine compound preparation for treating ErbB2-positive gastric cancer, comprising the following raw material components in parts by weight: 6 parts of Astragalus membranaceus, 4 parts of Codonopsis pilosula, 3 parts of Atractylodes macrocephala, 3 parts of turmeric, 3 parts of turmeric, 3 parts of fried chicken, bitter Ginseng 4 parts, Hedyotis diffusa 4 parts, Coix seed 3 parts.

[0053] The preparation method of the above-mentioned traditional Chinese medicine compound preparation for treating ErbB2-positive gastric cancer is as follows: S1. Add ethanol to turmeric, curcuma, fried gallinaceae, flavescens, diffusa, coix seed, extract 1-3 times, Extract for 0.5-3 hours each time to obtain extract A, recover the solvent under reduced pressure, concentrate, dry, and pulverize to obtain extract A; S2. Decoct Codonopsis pilosula, Radix Astragali, and Atractylodes macrocephala for 0.5 hours, add 1-40 times the amount of water , heating and extracting...

Embodiment 3

[0055] A traditional Chinese medicine compound preparation for treating ErbB2-positive gastric cancer, comprising the following raw material components in parts by weight: 6 parts of Astragalus membranaceus, 4 parts of Codonopsis pilosula, 3 parts of Atractylodes macrocephala, 3 parts of turmeric, 3 parts of turmeric, 3 parts of fried chicken, bitter Ginseng 4 parts, Hedyotis diffusa 4 parts, Coix seed 3 parts.

[0056] The preparation method of the above-mentioned traditional Chinese medicine compound preparation for treating ErbB2-positive gastric cancer is as follows: S1. Add ethanol to turmeric, curcuma, fried gallinaceae, flavescens, diffusa, coix seed, extract 1-3 times, Extract for 0.5-3 hours each time to obtain extract A, recover the solvent under reduced pressure, concentrate, dry, and pulverize to obtain extract A; S2. Decoct Codonopsis pilosula, Radix Astragali, and Atractylodes macrocephala for 0.5 hours, add 1-40 times the amount of water , heating and extracting...

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Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating ErbB2-positive gastric cancer and a preparation method thereof, and relates to the technical field of traditional Chinese medicine compound preparations. The traditional Chinese medicine compound preparation comprises the following raw material components in parts by weight: 5-7 parts of Astragalus membranaceus, 3 parts of Codonopsis pilosula ‑5 parts, 2‑4 parts of Atractylodes macrocephala, 2‑4 parts of turmeric, 2‑4 parts of turmeric, 2‑4 parts of Sophora flavescens, 3‑5 parts of fried chicken, 3‑5 parts of Hedyotis diffusa, coix seed 2‑4 servings. The raw material components of the traditional Chinese medicine compound preparation for the treatment of ErbB2-positive gastric cancer are astragalus, Codonopsis, Atractylodes macrocephala, turmeric, curcuma, Sophora flavescens, fried chicken, Hedyotis diffusa, Coix seed, through the cultivation of the original element and decocting Combined use of turbidity and detoxification to treat tumors can not only be used as a treatment for ErbB2-positive gastric cancer, but also prevent the recurrence and metastasis of ErbB2-positive gastric cancer. The curative effect is definite, and it can be used for a long time without any side effects.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compound preparations, in particular to a traditional Chinese medicine compound preparation for treating ErbB2-positive gastric cancer and a preparation method thereof. Background technique [0002] Gastric cancer is a common malignant tumor in the world, with a relatively poor prognosis and a serious threat to human health. According to statistics from the International Agency for Research on Cancer, more than 70% of new gastric cancer cases occurred in developing countries, and about 50% of the cases occurred in eastern Asia, mainly in China. The number of cases and deaths of gastric cancer in China accounted for about 42.6% and 45.0% of the global gastric cancer incidence and death respectively, ranking fifth in incidence and sixth in mortality among 183 countries in the world. my country is a country with a high incidence of gastric cancer. Compared with the lower inciden...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P35/00A61K35/57
CPCA61K36/481A61K36/344A61K36/284A61K36/9066A61K35/57A61K36/489A61K36/748A61K36/8994A61P35/00A61K2236/33A61K2236/39A61K2236/51A61K2236/331A61K2300/00
Inventor 孔凡铭贾英杰李小江杨佩颖廖冬颖
Owner 天津中医药大学第一附属医院
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