Cnoline compound PI3K kinase inhibitor as well as preparation method and application thereof in pharmacy

A technology of kinase inhibitors and compounds, applied in the field of medicinal chemistry, can solve the problems of not being able to treat PI3K kinase, not having PI3K kinase targeting, and achieving good therapeutic effect and safety effect
CN112876456AInactive Publication Date: 2021-06-01FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2021-06-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a cinnoline compound PI3K kinase inhibitor as shown in a formula I. In the cinnoline compound PI3K kinase inhibitor, and R1, R2 and R3 are defined in the specification. The invention also provides a pharmaceutical composition of the formula I or the salt thereof, a preparation method of the pharmaceutical composition and application of the pharmaceutical composition to treatment of inflammation caused by overexpression of PI3K kinase, immune diseases, cardiovascular diseases, cancers and other diseases related to PI3K kinase.
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Description

technical field

[0001] The invention relates to the technical field of medicinal chemistry, in particular to the preparation and drug combination of cinnoline compounds or salts thereof, and the application to diseases, diseases or conditions related to PI3K kinases. Background technique

[0002] Phosphatidylinositol 3-kinase (PI3K) is an important signal transduction molecule in cells. PI3K participates in the regulation of cell proliferation, differentiation and apoptosis by phosphorylating the 3-hydroxyl group on the phosphatidylinositol ring. Physiological processes such as death. The abnormal activation of PI3K caused by the mutation of the upstream gene of PI3K (such as PIK3CA) or the inactivation mutation of its negative regulatory gene PTEN have been observed in cancer cells. It can be said that PI3K is closely related to the occurrence and development of various cancers and non-cancerous diseases (Vivanco, I.; Sawyers, C.L., Nat. Rev. Cancer 2002, 2, 489.). PI3K k...

Claims

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