Methods for lowering blood pressure with a dihydropyridine-type calcium channel blocker pharmaceutical composition

A technology of calcium channel blocker and pharmaceutical composition, applied in the field of treatment and/or prevention of heart disease, which can solve problems such as unachieved results

Pending Publication Date: 2021-06-11
ASTRAZENCA UK LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when aiming to simulate 10 mg When a phase 3 "real use" trial of OTC use of (atorvastatin calcium) failed to meet its primary goal, it was not attempted in 2014 because patients followed instructions to check their LDL Unsatisfactory results in cholesterol (LDL-C) levels and taking appropriate action based on their test results after checking their LDL-C levels

Method used

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  • Methods for lowering blood pressure with a dihydropyridine-type calcium channel blocker pharmaceutical composition
  • Methods for lowering blood pressure with a dihydropyridine-type calcium channel blocker pharmaceutical composition
  • Methods for lowering blood pressure with a dihydropyridine-type calcium channel blocker pharmaceutical composition

Examples

Experimental program
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specific Embodiment approach

[0276] In one aspect, the present disclosure provides methods, software and computers for eligibility of a human individual for over-the-counter delivery of a dihydropyridine calcium channel blocker pharmaceutical composition for lowering blood pressure, e.g., for treating or preventing heart disease system. In one embodiment, a computer system (such as figure 2 The computer system 250 in ) includes instructions for conducting individual surveys (e.g. figure 2 Investigate module 204 in ) to obtain filters for at least two series (e.g. figure 2 The first filter class in 214 and figure 2 Information about individuals that is necessary for the second filter category 220 in ) to function. The computer system also includes instructions for running the findings against the filter. Filter 216 in the first series of filters prevents authorization for delivery of the OTC dihydropyridine calcium channel blocker when the individual's findings identify a contraindication for the O...

example 1

[0368] Example 1: A computer system configured to identify an individual for use in treating or preventing heart disease (e.g., by lowering blood pressure) in a pharmaceutical composition of amlodipine (e.g., 2-[(2-aminoethoxy) OTC delivery of methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate (RS)-3-ethyl ester 5-methyl ester) Qualifications. The computer system includes instructions for conducting a survey of an individual. Surveys are used to obtain one or more of the following: whether the individual is pregnant, breastfeeding, or planning to become pregnant; whether the individual is using dihydropyridine calcium channel blockers, including (but not limited to) amlodipine, nifedipine and / or isradipine; subject's systolic blood pressure; subject's diastolic blood pressure; whether subject has ever experienced an atherosclerotic cardiovascular event (eg, heart problem) or cardiac surgery; subject's sex; subject's age ( For example, whether the indiv...

example 2

[0378] Example 2: A computer system configured to identify an individual for a nisoldipine pharmaceutical composition (e.g., 2,6-dimethyl-4-(2-nitro phenyl)-1,4-dihydropyridine-3,5-dicarboxylate isobutyl methyl ester) is eligible for over-the-counter delivery. The computer system includes instructions for conducting a survey of an individual. Surveys are used to obtain one or more of the following: whether the individual is pregnant, breastfeeding, or planning to become pregnant; whether the individual is using dihydropyridine calcium channel blockers, including (but not limited to) amlodipine, nifedipine and / or isradipine; subject's systolic blood pressure; subject's diastolic blood pressure; whether subject has ever experienced an atherosclerotic cardiovascular event (eg, heart problem) or cardiac surgery; subject's sex; subject's age ( For example, whether the individual's age is greater than or equal to eighteen years); the individual's race; whether the individual is usi...

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Abstract

A method is provided for lowering blood pressure in a subject in need thereof by administering a dihydropyridine-type calcium channel blocker pharmaceutical composition to a subject qualified for over-the-counter access to the dihydropyridine-type calcium channel blocker pharmaceutical composition. In some embodiments, the dihydropyridine-type calcium channel blocker pharmaceutical composition includes isradipine, nifedipine, or nisoldipine. In some embodiments, the dihydropyridine-type calcium channel blocker pharmaceutical composition includes 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2- chlorophenyl)-6-methyl-l,4-dihydropyridine-3,5-dicarboxylate or a pharmaceutically acceptable salt thereof.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 62 / 685,209, filed June 14, 2018, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure generally relates to methods for lowering blood pressure, such as thereby treating and / or preventing heart disease, by administering an over-the-counter dihydropyridine calcium channel blocker pharmaceutical composition to an individual having a prescription-free Qualification for the composition is available. Background technique [0004] Hypertension, such as high blood pressure, is the leading cause of death worldwide and the second leading cause of preventable death in the United States. Roberts, N., et al., Emitro Health, Feeling the Pressure of New Guidelines for the Treatment of Hypertension, (2017). As of 2014, according to the CDC, 1 in 3 adults in the United States has high blood pressure...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H20/10G16H10/20G16H50/20A61K31/4422A61P9/12
CPCG16H10/20G16H20/10G16H50/20A61K31/4422G16H10/40G16H10/60G16H15/00G16H70/40
Inventor R·L·斯凯利J·菲罗尔
Owner ASTRAZENCA UK LTD
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