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Materials and methods for nerve repair with animal-sourced nerve grafts

A technology for nerve transplantation and grafts, which can be used in medical science, tissue regeneration, prostheses, etc., and can solve problems such as increased risk of muscle denervation

Pending Publication Date: 2021-06-29
阿克松根股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Breast nerve regeneration based on harvested autografts requires longer operating room procedures with increased risk of muscle denervation

Method used

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  • Materials and methods for nerve repair with animal-sourced nerve grafts
  • Materials and methods for nerve repair with animal-sourced nerve grafts
  • Materials and methods for nerve repair with animal-sourced nerve grafts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Example 1 - Surgical method of the present invention

[0057] Preoperative marking is performed while the patient is standing. Afterwards, the patient is brought into the operating room and placed on his back with both arms immobilized. The abdominal flap was incised in a standard lateral to medial manner ( figure 1 ), until the lateral rowperforators and associated intercostal nerves are exposed ( Figure 2A-2B ). The anterior rectus sheath was incised craniocaudally along the lateral row of perforators to expose the rectus abdominis, lateral perforators, and intercostal nerves (ICN)11 and ICN12( Figure 3A -3B).

[0058] After identifying ICN11 and / or ICN12, standard retrograde dissection of the sensory branch of the intercostal nerve ICN11 and / or ICN12 is traced next to the lateral column of the perforating vessels until the sensory-motor nerve Y is encountered up to the junction. Although visible intramuscularly or retromuscularly, this exposure can be achieve...

Embodiment 2

[0065] Example 2 - Advantages provided by the surgical method of the present invention

[0066] The homogeneity of the surgical approach is crucial to reliably evaluate the validity of a procedure concept such as surgery or breast nerve regeneration. Therefore, it is important to establish standardized surgical techniques to facilitate future comparative isomorphic analysis. A clear understanding of the principles of neurosurgery, as well as relevant expertise in the characteristics of viable reconstructive options such as nerve conduits, autografts, and engineered nerve allografts, are critical to the successful execution of this surgical recommendation important.

[0067] The standard treatment for nerve damage is tensionless primary repair when possible. However, if base repair is not possible, bridging materials are used, including nerve autografts, tube conduits, and processed nerve allografts. Nerve gaps encountered for breast nerve regeneration typically measure betw...

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PUM

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Abstract

The invention pertains to materials, including sets of nerve grafts, for performing breast neurotization with xenograft nerves in breast surgeries, such as reconstructive breast surgery. Certain embodiments of the set of nerve grafts comprise at least one or more nerve grafts prepared from one or more nerves, such as one or more intercostal nerves (ICNs), obtained from one or more animal sources. Such animal-sourced nerve grafts may be used as xenografts in the reconstruction of nerve defects in humans, and in particular, animal-sourced ICN grafts may be used as xenografts in the reconstruction of ICN nerve defects in humans, including through use of the breast neurotization technique described herein. These animal-sourced nerve grafts may also be used in the reconstruction of nerve defects in animal recipients, including as xenografts, allografts and autografts.

Description

Background technique [0001] The earliest descriptions of breast cancer date back to 480 BC in the early medical records of the ancient Greeks and Egyptians. However, modern treatment did not begin until Halsted performed the first mastectomy in the 1880s. Since then, the understanding and treatment of breast cancer has come a long way. Today, post-mastectomy breast reconstruction is an essential element of breast cancer care. Although implant-based breast reconstruction is the more common form of reconstruction today, long-term patient satisfaction has been reported to be higher after autologous reconstruction. Therefore, it is not surprising that many patients opt for this type of reconstruction. Despite significant technical advances in autologous reconstruction, such as the development of perforator-based flaps that minimize donor-site morbidity, abdominal wall weakness is associated with donor-site hernias ( hernias) remains a serious complication. [0002] Interestin...

Claims

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Application Information

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IPC IPC(8): A61L27/36
CPCA61L2430/32A61L27/3604A61L27/3675A61L27/36
Inventor 伊维卡·杜契奇
Owner 阿克松根股份公司