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Hair growth promoting composition comprising guanidine derivative

A composition and compound technology, applied in the directions of drug combination, medical preparations containing active ingredients, hair care, etc., can solve the problem of not obvious effect, and achieve the effect of excellent efficacy, promotion of hair growth, and excellent hair follicle regeneration.

Pending Publication Date: 2021-07-23
KOREA RES INST OF BIOSCI & BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, minoxidil has many side effects, such as ineffectiveness, contact dermatitis such as scalp puffiness, erythema, horniness, etc. (Journal of the Korea Medical Association, 56(1), 45)

Method used

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  • Hair growth promoting composition comprising guanidine derivative
  • Hair growth promoting composition comprising guanidine derivative
  • Hair growth promoting composition comprising guanidine derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] Example 1. Reprogramming effect of guanidine derivatives

Embodiment 11

[0109] Example 1.1. Comparison of reprogramming effects of guanidine derivatives in mouse cells

[0110] It was confirmed that when a subtoxic dose (10 nM) of rotenone (ETC complex I inhibitor) promotes effective somatic cell reprogramming, the effects of rotenone and the guanidine derivative of the present invention for generating iPSCs were compared as follows ( figure 2 ).

[0111] During reprogramming into iPSCs by introducing OSKM reprogramming factors into mouse embryonic fibroblasts (MEFs), rotenone, the guanidine derivative of the present invention, and phenformin were treated at labeled concentrations. After 14 days, alkaline phosphatase (AP) staining ( figure 2 A), and quantify the results of the number of AP+ colonies ( figure 2 B), IM 156 and phenformin did not show the effect of promoting reprogramming, on the contrary, due to the treatment of IM176OUT 05, IM176OUT 04 and IM177OUT 02, the number of AP+ colonies was increased instead. In particular, when IM17...

Embodiment 12

[0112] Example 1.2. Confirmation of the reprogramming effect of guanidine derivatives in human cells

[0113] During reprogramming into iPSCs by introducing OSKM reprogramming factors into human foreskin fibroblasts (HFF), IM176OUT 05, IM176OUT 04, and IM177OUT 02 whose reprogramming effects on mouse cells were confirmed in the above-mentioned Example 1.1. Treatments were performed at labeled concentrations. After 28 days, complete AP staining ( image 3 A), and quantify the results of the number of AP+ colonies ( image 3 B), the three compounds showed the best reprogramming effect when treated at a concentration of 10nM. In particular, it was confirmed that when IM176OUT 05 was treated at a concentration of 10nM, 100nM and 500nM, they all showed an efficiency of more than 2.4 times Improve the effect of reprogramming.

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Abstract

The present invention relates to a hair improving composition, and more specifically, to a hair growth promoting or hair loss preventing and treating composition comprising a non-toxic guanidine derivative as an active ingredient. The composition has an excellent effect of promoting hair growth and reproducing hair follicles, and thus may be usefully employed in various areas such as pharmaceutical, food, feed and cosmetic compositions for promoting hair growth or preventing, treating and reducing hair loss.

Description

technical field [0001] The present invention relates to a composition for promoting hair growth, in particular to a pharmaceutical composition containing guanidine derivatives as active ingredients for promoting hair growth. Background technique [0002] Hair repeats a cycle of three phases, the growth phase (anagen), the degenerative phase (catagen) connected with the extinction of the hair, and the resting phase (telogen) where the hair stops growing. If the amount of hair in the anagen period decreases and the ratio of catagen and telogen increases, the hair will fall out abnormally, resulting in hair loss. Various attempts have been made to treat hair loss, such as surgical methods such as hair transplantation, or drug therapy. Surgical operation method, although the effect is very excellent, but the disadvantage is that the cost is huge, the operation process is difficult, and the economic and mental burden of the patient is very heavy. In addition, this is only a tem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/155A61P17/14A61K8/43A61Q7/00
CPCA61Q7/00A61K8/43A61P17/14A61K31/155
Inventor 孙命辰郑璟淑金成吴菊智爱李洪范柳尚熙权唯贞文宣周安智苑柳载成
Owner KOREA RES INST OF BIOSCI & BIOTECH
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