Application of proteasome inhibitor PR171 in preparation of medicine for treating osteoporosis

A proteasome inhibitor, osteoporosis technology, applied in the application field of proteasome inhibitor PR171 in the preparation of osteoporosis drugs, can solve the problem of insufficient selectivity, to reduce or weaken activity, inhibit differentiation, promote proliferating effect

Pending Publication Date: 2021-08-03
AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES +1
View PDF8 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is: the selectivity of existing drugs for the treatment of osteoporosis is insufficient

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of proteasome inhibitor PR171 in preparation of medicine for treating osteoporosis
  • Application of proteasome inhibitor PR171 in preparation of medicine for treating osteoporosis
  • Application of proteasome inhibitor PR171 in preparation of medicine for treating osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0036] The technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings and embodiments. Apparently, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0037] 1. Experimental method

[0038] 1. Preparation of PBS (phosphate buffered saline solution) (10X concentrated solution):

[0039] Take 80g NaCl, 2gKCl, 37.08g Na with electronic balance 2 HP0 4 12H20, 2.4gKH 2 P0 4 powder, placed in a lL beaker. Add 800ml of distilled water to the beaker to fully dissolve and adjust the pH value to 7.4 with the help of concentrated HCl with the help of an electronic pH meter, then use distilled water to make up to 1L again, and then sterilize at hig...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of osteoporosis medicines, and in particular, relates to an application of a protease inhibitor PR171 in preparation of a medicine for treating osteoporosis. The proteasome inhibitor is applied to preparation of the osteoporosis medicine, so that the proteasome inhibitor PR171 inhibits the activity of proteasome, then the content expression of beta-catenin in osteoclasts is increased, the balance of bone formation and bone resorption is broken, the activity of the osteoclasts is reduced or weakened, osteoclast differentiation is inhibited, and more proliferation of the osteoblasts is promoted, so that the purposes of bone generation and growth are achieved; particularly, the content of PR171 in the medicine for treating osteoporosis is 10-25 [mu]mol/L.

Description

technical field [0001] The invention relates to the technical field of osteoporosis drugs, in particular to the application of a proteasome inhibitor PR171 in the preparation of drugs for treating osteoporosis. Background technique [0002] Osteoporosis (OP) is a systemic and metabolic bone disease, which refers to the reduction of bone content and changes in bone microstructure in the human body. Fractures increase bone fragility and easily lead to fractures, especially hip fractures, resulting in a significant reduction in the patient's physical function and quality of life. With the development of economy and society, and the aging of society, OP is one of the common chronic diseases, ranking first among the bone diseases of the elderly, making patients, especially postmenopausal women, more prone to fragility fractures. Therefore, the ultimate goal of treating osteoporosis is to restore the pre-fracture level of function and reduce the risk of subsequent fractures. [...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61P19/10
CPCA61K38/08A61P19/10
Inventor 唐毓金刘佳张帆李凯杨成亮王翀韩超梁清洋王立强黄可谢克恭蓝常贡
Owner AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap