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Triple inactivated vaccine for duck circovirus disease, novel duck reovirus disease and duck virus hepatitis and preparation method of triple inactivated vaccine

A technology of duck viral hepatitis and duck circovirus, which is applied in the field of preparation of the triple inactivated vaccine, achieves the effects of high vaccine titer content, simple preparation method and low cost

Pending Publication Date: 2021-10-12
哈药集团生物疫苗有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effective vaccine for preventing and controlling these three diseases at the same time, so it is especially important to develop a safe and effect

Method used

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  • Triple inactivated vaccine for duck circovirus disease, novel duck reovirus disease and duck virus hepatitis and preparation method of triple inactivated vaccine
  • Triple inactivated vaccine for duck circovirus disease, novel duck reovirus disease and duck virus hepatitis and preparation method of triple inactivated vaccine
  • Triple inactivated vaccine for duck circovirus disease, novel duck reovirus disease and duck virus hepatitis and preparation method of triple inactivated vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation of duck circovirus disease, new duck reovirus disease, duck viral hepatitis triple inactivated vaccine

[0032] 1. Poison species

[0033] The new duck reovirus S strain (preserved in the General Microorganism Center of China Committee for Microbial Culture Collection, CGMCC No.20000), the type 1 duck hepatitis A virus JS strain (preserved in China Microorganism Culture Collection Management Committee) for seedling production General Microbiology Center, Microbiological Preservation No.: CGMCC No.6852) and Type 3 Duck Hepatitis A Virus SD Strain (preserved in the General Microbiological Center of China Committee for the Collection of Microorganisms, Microbiological Preservation No.: CGMCC No.8506) are both from Kazakhstan Separation, identification, storage and supply by Pharmaceutical Group Biovaccine Co., Ltd.

[0034] 2. Preparation method

[0035]1 Preparation of duck circovirus CAP protein

[0036] 1.1 Design and synthesis of duck circoviru...

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PUM

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Abstract

The invention discloses a triple inactivated vaccine for duck circovirus disease, novel duck reovirus disease and duck virus hepatitis and a preparation method of the triple inactivated vaccine. The triple inactivated vaccine comprises an effective amount of inactivated antigens and immunologic adjuvants in immunization, and the inactivated antigens include a duck circovirus antigen, a novel duck reovirus antigen and a duck hepatitis virus antigen. The invention further discloses a method for preparing the triple inactivated vaccine. The triple inactivated vaccine for the duck circovirus disease, the novel duck reovirus disease and the duck virus hepatitis is good in safety and does not generate mutual interference or influence of antigen components. Immune protection efficacy tests prove that the triple inactivated vaccine can prevent duck reovirus, duck circovirus and duck hepatitis virus at the same time, can avoid adverse reactions caused by multiple inoculation immunization, and has the advantages of simple preparation method, convenience, multiple effects, low cost, high vaccine titer content and the like.

Description

technical field [0001] The invention relates to a triple inactivated vaccine for preventing and treating duck virus disease, in particular to a triple inactivated vaccine for duck circovirus disease, new duck reovirus disease and duck viral hepatitis. The present invention further relates to the triple inactivated vaccine The preparation method belongs to the field of duck circovirus disease, new duck reovirus disease, duck viral hepatitis triple vaccine and its preparation field. Background technique [0002] New duck reovirus disease is a disease characterized by spleen enlargement, hemorrhage, and necrosis. Since 2017, it has been found in duck farms in Shandong, Henan, and Jiangsu. The susceptible days are mostly in the range of 5d-25d, the incidence rate is generally between 10%-70%, and the mortality rate is generally between 50%-60%. The younger the age, the higher the morbidity and mortality. Both morbidity and mortality increased significantly in cold weather envi...

Claims

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Application Information

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IPC IPC(8): A61K39/12A61P31/20A61K39/39A61K39/15A61P31/14C07K14/01C12N15/34C12N15/85C12N15/66
CPCA61K39/12A61K39/39A61P31/14A61P31/20C07K14/005C12N15/85C12N15/66C12N2720/12234C12N2800/22C12N2750/10022C12N2750/10034C12N2770/32334A61K2039/70A61K2039/552A61K2039/5252A61K2039/55511
Inventor 宋扬柴华梁宛楠徐刚李应鹤曹宝珠刘洋宋莹张影孟福强
Owner 哈药集团生物疫苗有限公司
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