A preparation for improving the menstrual cycle of patients with polycystic ovary syndrome
A polycystic ovary and menstrual cycle technology, applied in the field of medicine, can solve the problems of no menstrual cycle research and achieve the effect of improving menstrual cycle and pregnancy rate
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Embodiment 1
[0019] Example 1: Tablet Composition
[0020] Isobuthrenone 2g
[0021] Berberine Hydrochloride 1g
[0022] Microcrystalline Cellulose 20g
[0023] Lactose 20g
[0024] Starch 6g
[0025] Talc powder 1.5g
[0026] Magnesium stearate 0.5g
[0027] Preparation method: mix the berberine hydrochloride, isubuthrenone, microcrystalline cellulose and lactose in the amount shown in the formula and granulate with 10 mg / ml gelatin solution, then sieve the wet granules and dry, then mix with Starch, talcum powder and magnesium stearate are mixed, sieved, and compressed into tablets, each containing berberine hydrochloride 0.01g.
Embodiment 2
[0028] Example 2: Tablet Composition
[0029] Isobuthrenone 2g
[0030] Berberine Hydrochloride 1.5g
[0031] Microcrystalline Cellulose 20g
[0032] Lactose 20g
[0033] Starch 6g
[0034] Talc powder 1.5g
[0035] Magnesium stearate 0.5g
[0036] Preparation method: mix the berberine hydrochloride, isubuthrenone, microcrystalline cellulose and lactose in the amount shown in the formula and granulate with 10 mg / ml gelatin solution, then sieve the wet granules and dry, then mix with Starch, talcum powder and magnesium stearate are mixed, sieved, and compressed into tablets, and each tablet contains berberine hydrochloride 0.015g.
Embodiment 3
[0045] Embodiment 3 animal pharmacodynamics experiment
[0046] 1 Animal model construction and administration
[0047] 70-day-old healthy and clean female SpraguDawley (SD) rats were selected to establish the polycystic ovary syndrome (PCOS) rat model according to the Poretsky method, and 3.0 U / d of human chorionic gonadotropin (HCG) was injected subcutaneously twice a day. From day 1 to day 10, the injection of intermediate-acting insulin started from 0.5U / d and gradually increased to 6.0U / d, and then injected at this dose every day. After 22 days, the levels of testosterone and insulin in the blood of the rats increased and the vaginal smears continued to appear angular. Cellular cells are in line with the PCOS model.
[0048] After successful modeling, 80 female rats with modeling results were divided into 4 groups, 20 in each group, respectively experimental group 1, experimental group 2, comparative group 1 and control group; 20 rats were used as blank group.
[0049]...
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