Polyglycol modified recombinant human interferon

A technology of recombinant human interferon and polyethylene glycol, applied in the field of interferon, can solve the problems of short half-life in vivo and obvious side effects, and achieve long half-life in vivo, good thermal stability and enzyme stability, and low plasma clearance rate Effect
CN1375502AInactive Publication Date: 2002-10-23CHINA PHARM UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHINA PHARM UNIV
Publication Date
2002-10-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The recombinant human interferon modified by polyethylene glycol is characterized by that on the recombinant human interferon one or two or more than two polyethylene glycol chains can be connected, said recombinant human interferon can be interferon alpha 2b, and the average degree of polymerization of said polyethylene glycol chain is 45-230. Said invented recombinant human interferon has the physiological activity of the interferon, and its stability is superior to that of interferon, its plasma clearance is low, the half-life period in vivo is long, it can be used for preparing the medicines for resisting virus and resisting cancer. Said invention also discloses its preparation method.
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Claims

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