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Sustained release system and method for ocular delivery of carbonic anhydrase inhibitors

A technology of carbonic anhydrase and sustained release, which is applied in capsule delivery, drug delivery, pill delivery, etc., and can solve problems such as difficult to achieve zero-time release

Inactive Publication Date: 2006-04-05
普斯维达美国有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, zero-shot release may be difficult to achieve with matrix systems

Method used

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  • Sustained release system and method for ocular delivery of carbonic anhydrase inhibitors
  • Sustained release system and method for ocular delivery of carbonic anhydrase inhibitors
  • Sustained release system and method for ocular delivery of carbonic anhydrase inhibitors

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Embodiment Construction

[0024] The present invention provides devices and methods for delivering and maintaining a therapeutic amount of at least one carbonic anhydrase inhibitor to the ciliary body of a patient's eye for an extended period of time. The device is a sustained release drug delivery device comprising at least one carbonic anhydrase inhibitor capable of maintaining a therapeutically effective concentration of the carbonic anhydrase inhibitor in the ciliary body for an extended period of time. The method includes inserting the device into or near the eye of the patient to deliver the carbonic anhydrase inhibitor to the ciliary body.

[0025] The device of the invention may be adapted for insertion into the eye and between the eyelids, preferably the lower eyelids. In other embodiments it may be adapted for insertion into the subretinal anterior or posterior chamber, into the choroid, or into or on the sclera. In another embodiment, the device may be adapted for insertion into a lacrimal ...

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Abstract

The invention provides a device and method for treating and / or preventing raised intraocular pressure, such as that associated with glaucoma or the use of corticosteroids with adrenergic agents. The invention provides insertable sustained-release devices adapted to maintain a therapeutically effective concentration of one or more adrenergic agents for an extended period of time, and a method of use thereof.

Description

field of invention [0001] The present invention relates to the field of sustained delivery of drugs to the eye, and in particular to the treatment and / or prevention of elevated intraocular pressure, such as that associated with glaucoma or the use of corticosteroids, by sustained delivery of carbonic anhydrase inhibitors to the eye. Background of the invention [0002] 1. Carbonic anhydrase inhibitors [0003] Glaucoma is one of the leading causes of blindness in developed countries of the world. The main pathological feature of glaucoma is elevated intraocular pressure. Surgery and / or drugs aimed at lowering intraocular pressure are the most common treatments for glaucoma. The main drug therapies currently in use are the administration of miotics (eg, pilocarpine, carbachol, and echothiophate), which open the trabecular network to increase the rate of fluid flow out of the eye; and administration of beta-blockers (eg, timolol, levobunolol, carteolol, and betaxolol), alph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/00A61K9/32A61K9/50A61K31/382A61K31/542A61L27/34A61L27/54A61L31/10A61L31/16
CPCA61L27/34A61K9/5031A61L2300/602A61K9/0092A61L2300/21A61K31/382A61L31/16A61L31/10A61K31/542A61L27/54A61L2300/436A61K9/0051A61P27/06A61K9/209A61K9/28
Inventor 保罗·阿什顿郭红
Owner 普斯维达美国有限公司
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