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Polyethylene glycol electrolyte oral solution

A polyethylene glycol, oral solution technology, applied in the direction of sulfur/selenium/tellurium active ingredients, alkaline/alkaline earth metal chloride active ingredients, metabolic diseases, etc. Permeability, uneven component ratio and other problems, to achieve the effect of fast onset, good cleaning effect and controllable quality

Active Publication Date: 2011-06-29
BEIJING SHENGYONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The problem is that there is a loss of components when preparing the solution, resulting in uneven proportioning of the components; or because there is no accurate metering container, and the user's own problems deliberately increase or decrease the amount of water added, so that the solution of the final product There is a deviation in the concentration, and the osmotic pressure ratio of the solution cannot be guaranteed to be 1, and the isotonicity inside and outside the intestinal tract cannot be guaranteed, which not only affects the cleaning effect, but also may cause serious adverse reactions
[0011] At present, there are only a few hospitals in China that use "powder" for intestinal cleansing, and there are only a few who have the conditions to strictly control the preparation of drug solutions. Serious consequences of improper preparation

Method used

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  • Polyethylene glycol electrolyte oral solution
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Take 59g of polyethylene glycol (PEG-4000), 1.47g of sodium chloride, 0.74g of potassium chloride, 1.69g of sodium bicarbonate, 5.69g of sodium sulfate (anhydrous), 0.02g of calcium sodium edetate, and 0.5g of sodium saccharin g. Pineapple essence 1ml;

[0051] Put polyethylene glycol, sodium chloride, potassium chloride, and sodium sulfate in the same container, add 50mL of water, heat to 40°C to dissolve, and stir, add 1g of activated carbon, heat to boiling, keep boiling for 10min, stop heating, When the temperature of the solution drops to 30°C, filter to remove the activated carbon, and wash the activated carbon layer with 50mL of water, and merge the washing liquid into the filtrate;

[0052] Dissolve sodium bicarbonate, calcium sodium edetate, and sodium saccharin in 50 mL of water;

[0053] Combine the above filtrate and solution, add pineapple essence, add water to a total volume of 1000ml, and mix well;

[0054] Sampling was taken to determine that the pH va...

Embodiment 2

[0057] Take 60g polyethylene glycol (PEG-4000), 1.1g sodium chloride, 0.8g potassium chloride, 1.7g sodium bicarbonate, 5.8g sodium sulfate (anhydrous), 0.5g disodium edetate, 0.02 stevioside g. Strawberry essence 2ml;

[0058] Put polyethylene glycol, sodium chloride, potassium chloride, and sodium sulfate in the same container, add 100mL of water, heat to 50°C to dissolve, and stir, add 0.5g of activated carbon, heat to boiling, keep boiling for 5min, stop heating , when the temperature of the solution drops to 25°C, filter to remove the activated carbon, and wash the activated carbon layer with 50mL of water, and merge the washing liquid into the filtrate;

[0059] Dissolve sodium bicarbonate, disodium edetate, and stevioside in 50 mL of water;

[0060] Combine the above filtrate and solution, add strawberry essence, add water to a total volume of 1000ml, and mix well;

[0061] Sampling was taken to determine that the pH value was 8.5, fine filtration was performed with a...

Embodiment 3

[0063] Take 59g of polyethylene glycol (PEG-4000), 1.5g of sodium chloride, 0.5g of potassium chloride, 2.0g of sodium bicarbonate, 5.9g of sodium sulfate (anhydrous), 0.1g of calcium sodium edetate, and 0.3g of sodium saccharin g. Banana essence 1.5ml;

[0064] Put polyethylene glycol, sodium chloride, potassium chloride, and sodium sulfate in the same container, add 100mL of water, heat to 45°C to dissolve, and stir, add 1g of activated carbon, heat to boiling, keep boiling for 5min, stop heating, When the temperature of the solution drops to 30°C, filter to remove the activated carbon, and wash the activated carbon layer with 100mL of water, and add the washing liquid to the filtrate;

[0065] Dissolve sodium bicarbonate, calcium sodium edetate, and sodium saccharin in 80 mL of water;

[0066] Combine the above filtrate and solution, add banana essence, add water to a total volume of 1000ml, and mix well;

[0067] Sampling was taken to determine that the pH value was 7.5,...

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Abstract

The present invention provides a polyethylene glycol-electrolyte oral solution. Its is made up by using 59-60 g of polyethylene glycol, 1.0-1.5 g of sodium chloride, 0.5-1.0 g of potassium chloride, 1.5-2.0 g of sodium hydrogen carbonate, 5.5-6.0 g of sedium sulfate, 0.02-0.5 g of egtazide, 0.02-0.5 g of sweetener and 1-2 ml of edible essence, and adding deionized water to 1000 ml. It mainly is applicable to colonoscopy, barium enema X-ray examination and intestinal tract ablution, etc. and also can be used for curing chronic constipation.

Description

technical field [0001] The invention relates to a polyethylene glycol-electrolyte oral solution, which belongs to the field of pharmaceutical preparations. Background technique [0002] With the continuous improvement of people's living standards, the number of intestinal cancer and various intestinal diseases increases, and the number of intestinal operations and colonoscopy examinations is increasing day by day. [0003] According to preliminary investigations, only about 40,000 to 50,000 patients with colonic diseases in large hospitals in Beijing, Shanghai, and Tianjin need medical treatment, examination and treatment every year, while intestinal cleansing and pretreatment methods basically stay in foreign countries in the 1960s and 1970s Level of traditional intestinal cleansing method; that is: 2 to 3 days before the colonoscopy, only take a liquid or low-residue diet, plus laxatives and enemas before the colonoscopy, etc. Many hospitals also use mannitol to make an is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/765A61K33/14A61K33/04A61P3/12
Inventor 陶忠华张红妹刘静朱莉亚
Owner BEIJING SHENGYONG PHARMA
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