Methods of modulating cytokine activity; related reagents

一种IL-23、IL-23R的技术，应用在哺乳动物细胞因子领域，能够解决不能有效产生、没有得到满足等问题

Inactive Publication Date: 2007-04-04
MERCK & CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Long-term and widespread immunity to influenza may depend on production of CD8 + The ability to respond with T cells, but this response is often ineffective with current vaccines
There is an unmet need to provide viral protection during primary and secondary immune responses against, for example, influenza viruses

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

I. General approach

[0093]Standard techniques are available to characterize viruses, modify viruses by genetic engineering, and treat and diagnose viral infections (see, e.g., Mahy and Kango (1996) Virology Methods Manual, Academic Press, San Diego, CA; Flint et al. (2003) Principles of Virology: Molecular Biology, Pathogenesis, and Control of Animal Viruses, Am. Soc. Microbiol., Wasn. D.C.; Fields et al. (eds.) (2001) Virology, Lippincott, Williams, and Wilkins, NY, NY; Cann (2001) Principles of Molecular Virology, Academic Press, San Diego, CA; White and Fenner (1994) Medical Virology, 4th ed., Academic Press, San Diego, CA; Murphy et al. (1999) Veterinary Virology, 3rd ed., Academic Press, San Diego, CA; Richman et al. (ed.) (2002) Clinical Virology, 2nd ed., Am. Soc. Microbiol., Wash. D.C.).

[0094] Methods for performing flow cytometry, including fluorescence-activated cell sorting (FACS), are available (see, e.g., Owens et al. (1994) Flow Cytometry Principles for Clin...

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PUM

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Abstract

Provided are methods of modulating cytokine activity, e.g., for the purpose of treating viral infections. Also provided are reagents for use in screening for agonists or antagonists of IL-23.

Description

field of invention [0001] The present invention generally relates to the use of mammalian cytokines. More specifically, the present invention discloses the function of cytokines in the treatment of influenza virus. Background of the invention [0002] The immune system protects individuals against infectious agents such as viruses, bacteria, multicellular organisms, and cancer. This system includes several types of lymphoid and myeloid cells such as monocytes, macrophages, dendritic cells (DC), eosinophils, T cells, B cells and neutrophils. These lymphoid and myeloid cells tend to produce signaling proteins called cytokines. The immune response involves inflammation, the accumulation of immune cells throughout the body or in specific locations on the body. In response to infectious agents or foreign substances, immune cells secrete cytokines, which in turn regulate immune cell proliferation, development, differentiation, or migration. Cytokines ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/20A61K38/17A61K31/7088A61K39/395A61P31/12A61K48/00C07K14/54G01N33/569G01N33/68
CPCA61K48/00A61K38/20C07K14/54A01K2207/20A01K2227/105A61K31/7088A61K39/3955G01N33/56983C12N15/00G01N33/6869A61K38/208A01K67/0276G01N2500/00A01K2267/0337A61K38/1793G01N2800/26A01K2217/056G01N2333/11A61P31/12A61P31/14A61P31/16A61P43/00A61K2300/00
Inventor P·D·卡特西基斯I·迪米特里欧D·J·夸
Owner MERCK & CO INC
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