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Regulation of food preference using GLP-1 agonists

a technology of glp-1 and agonist, which is applied in the field of glp-1 agonists, can solve problems such as general regarded as unhealthy, and achieve the effect of increasing the intake of sweet or fat food and modifying the intake of food

Inactive Publication Date: 2007-04-12
NOVO NORDISK AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006] Despite this in-dept knowledge it as never been described that a GLP-1 agonist has the effect of specifically modifying the intake of food associated with an unhealthy western world lifestyle. This effect could be useful in the treatment of all kinds of disorders linked to an increased intake of sweet or fat food.

Problems solved by technology

This lifestyle is often referred to as “western world lifestyle”, and it is generally regarded as unhealthy.
Also, some human beings have cravings for sweet and / or fat food, sometimes enhanced by stress or premenstrual tension, or they may have psychological problems manifested as binge eating or compulsive eating habits.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0149] Diet induced obesity (DIO) was introduced over 2½ months, by feeding 4 months old rats a diet consisting of chow and 5 alternating kinds of candy (chocolate, chocolate bisquits, sugar). The candy was changed every day, so that the same candy was offered every fifth day. A lean control group was fed chow only. In the DIO group this was followed by a 12-week treatment with liraglutide (0.2 mg / kg s.c. bid, n=10). The candy and chow offer was continued for the whole treatment period also. Vehicle was given to both obese (n=14) and lean control rats (n=15). Food intake, differentiated between chow and candy, was monitored daily.

[0150] Liraglutide significantly (p=0.009) reduced total cumulated caloric intake (4452.3±150.6 vs. 5061.2±99.9 kcal). This reduction was a selective reduction in calories obtained from candy (2863.3±200.9 vs. 3803.2±110.2 kcal, p=0.017), since there was actually an increase in calories obtained from chow (1589.0±96.9 vs.1248.5±71.6 kcal, p=0.001).

[0151] ...

example 2

[0153] An experiment showing the effect of GLP-1 agonists in humans may be designed as described here. Human subjects are administered one or several daily dose(s) of a GLP-1 agonist leading to pharmacological active GLP-1-like levels in the blood or a placebo compound. The subjects are given a choice of foods and drink from one or more of the groups A) to D) and one or more from the groups E) to H). [0154] A) The glycemic index is above 60% [0155] B) The glycemic index is above 40% and wherein more than 30% of the total amount of energy stems from fat [0156] C) The amount of mono- or di-saccharides together constitute more than 25% of total carbohydrate content [0157] D) The amount of mono- or di-saccharides together constitute more than 25% of total carbohydrate content and wherein more than 30% of the total amount of energy stems from fat [0158] E) The glycemic index is below 60% [0159] F) The glycemic index is below 40% and wherein less than 30% of the total amount of energy ste...

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Abstract

GLP-1 agonists selectively decrease the amount of food intake, wherein the food has a high glycemic index or wherein the amount of mono-and di-saccharides together constitute a large proportion of the total amount of carbohydrates.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a continuation of International Application Number PCT / DK2004 / 000853, filed Dec. 9, 2004, which claims priority to Danish Patent Application Number PA 2003 01816, filed Dec. 9, 2003, and U.S. Provisional Application No. 60 / 529,480, filed Dec. 15, 2003, the contents of each of which is incorporated herein in its entirety.FIELD OF THE INVENTION [0002] The present invention relates to the use of GLP-1 agonists to reduce calorie intake from foods with a high glycemic index, or from foods wherein a high proportion of the carbohydrates is constituted by mono-and di-saccharides. BACKGROUND OF THE INVENTION [0003] Lifestyle in many parts of the world today is characterized by an enormous meal and “between-meal” intake of calories from solid food and snacks as well as drinkable calories. This lifestyle is often referred to as “western world lifestyle”, and it is generally regarded as unhealthy. Our food earlier consisted of a...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/26A61K38/00A61K38/22A61P3/04C07K14/605
CPCA61K38/26A61K38/2278A61P1/14A61P3/04A61P3/08A61P43/00
Inventor RAUN, KIRSTENVON VOSS, PIAKNUDSEN, LISELOTTE BJERREMALMLOF, KJELL
Owner NOVO NORDISK AS