Substance p-saporin (sp-sap) conjugates and methods of use

a technology of substance psaporin and conjugates, which is applied in the field of substance psaporin (spsap) conjugates and methods of use, can solve the problem of not unambiguously identifying the site of action, and achieve the effect of reducing the perception of pain

Inactive Publication Date: 2011-02-03
ADVANCED MARKETING SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current state of knowledge, however, does not unambiguously identify the site of action for these and many other effects of SP.

Method used

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  • Substance p-saporin (sp-sap) conjugates and methods of use
  • Substance p-saporin (sp-sap) conjugates and methods of use
  • Substance p-saporin (sp-sap) conjugates and methods of use

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Embodiment Construction

[0022]This invention provides a conjugate comprising Substance P and Saporin (SP-SAP). In one embodiment the conjugate comprises an analog of Substance P. In another embodiment the conjugate comprises an analog of Saporin.

[0023]This invention provides a conjugate comprising a Substance P analog having the amino acid sequence CYGGGGGGRPKPQQFFSarLMet(02)-amide (SEQ ID No. 1) and Saporin ([Sar9,Met(02)11]-SP-SAP). This invention provides a conjugate comprising a Substance P analog having the amino acid sequence at the N-terminus CYGGGGGGRPKPQQFFGLM-amide (SEQ ID No. 2) and Saporin (SP-SAP).

[0024]This invention provides a conjugate comprising Substance P and a ribosome-inactivating protein.

[0025]This invention provides a conjugate comprising a Substance P analog having the amino acid sequence CYGGGGGGGRPKPQQFFSarLMet(02)-amide and a ribosome-inactivating protein. In one embodiment the ribosome-inactivating protein is ricin A chain, gelonin, pokeweed antiviral protein, or a bacterial tox...

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Abstract

This invention provides a conjugate comprising Substance P, or an analog thereof, and a protein, such as Saporin, that inhibits protein synthesis.This invention provides a method of reducing the perception of pain by a subject comprising administering to the subject an effective amount of the pharmaceutical composition of the conjugate comprising Substance 9, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to reduce the perception of pain by the subject.This invention provides a method of selectively destroying NK-1R-expressing neuronal cells in a subject comprising administering to the subject an effective amount of the conjugate comprising Substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, so as to selectively destroy NK-1R-expresssing neuronal cells.Lastly, this invention provides a method for treating a NK-1R-associated disorder in a subject, which comprises administering to the subject an amount of the pharmaceutical composition comprising substance P, or an analog thereof, and a protein such as Saporin that inhibits protein synthesis, in an effective amount to treat the disorder associated with the NK-1R.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of application Ser. No. 10 / 813,856, filed Mar. 30, 2004, which is a continuation of application Ser. No. 09 / 523,790, filed Mar. 13, 2000, now abandoned, which is a continuation-in-part of application Ser. No. 08 / 890,157, filed Jul. 9, 1997, now U.S. Pat. No. 6,063,758, all of which are incorporated by reference herein.[0002]Throughout this application, various publications may be referenced by Arabic numerals in parenthesis. Full citations for these publications may be found at the end of the Detailed Description of the Invention. The disclosures of all publications cited herein are in their entirety hereby incorporated by reference into this application to more fully describe the state of the art to which this invention pertains.BACKGROUND OF THE INVENTION[0003]Many neurons synthesize and secrete small peptides that act on specific postsynaptic receptors and modify the activity of target neurons. Specif...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/16C07K19/00C12N9/96A61P25/00A61P35/00A61K38/00A61K47/48C07K7/22C07K14/415
CPCA61K38/00A61K47/48238C07K2319/00C07K14/415C07K7/22A61K47/62A61P25/00A61P35/00
Inventor LAPPI, DOUGLAS A.WILEY, RONALD G.
Owner ADVANCED MARKETING SYST
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