Methods, systems, and compositions for neuronal differentiation of multipotent stromal cells

a multi-potent stromal cell and neuronal differentiation technology, applied in the field of methods, systems and compositions for neuronal differentiation of multi-potent stromal cells, can solve the problems of loss or abnormality of system function, limited therapeutic options for treating and restoring such cells and system functions, and achieve cell or system function reduction

Active Publication Date: 2012-06-14
EXOSTEM BIOTEC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0003]Without limitation to only those embodiments described herein and without disclaimer, some embodiments of the invention comprise methods, systems, and compositions to selectively induce, whether in vitro or in vivo, the neuronal differentiation of multipotent stromal cells through the application of microRNAs, including but not limited to miRNA-124, miRNA-137 and/or miRNA-9* expres

Problems solved by technology

As one example only, some patients suffering stroke, spinal cord injury, or other neural injury and degeneration experience loss of functioning cell types, or neurological conditions like Parkinson's di

Method used

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  • Methods, systems, and compositions for neuronal differentiation of multipotent stromal cells
  • Methods, systems, and compositions for neuronal differentiation of multipotent stromal cells
  • Methods, systems, and compositions for neuronal differentiation of multipotent stromal cells

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examples

[0020]The following examples of some embodiments of the invention are provided without limiting the invention to only those embodiments described herein and without disclaiming any embodiments.

[0021]microRNAs

[0022]microRNAs (“miRNAs”) represent a family of endogenous, small (as some nonlimited examples, 19-23 nucleotides) non-coding RNAs that function through the RNA interference (“RNAi”) pathway to effect post-transcriptional gene silencing. miRNAs target the mRNAs of specific genes based on complementarity, and mediate either mRNA cleavage (perfect complementarity) or translation repression (partial complementarity). miRNAs have been demonstrated to play important roles in development and may function as fundamental genetic regulatory elements that serve to establish or maintain specific expression profiles determining cell fate.

[0023]Manipulating neuronal differentiation of MSCs may involve regulatory pathways that orchestrate the program of gene expression during the differentia...

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Abstract

Some embodiments of the invention comprise methods, systems, and compositions to selectively induce, whether in vitro or in vivo, the neuronal differentiation of multipotent stromal cells through the application of microRNAs, including but not limited to miRNA-124, miRNA-137 and/or miRNA-9* expression products of those miRNAs, and molecules and compositions containing functional elements of those miRNAs. Some embodiments of the invention also comprise the therapeutic administration and use of such induced cells to treat mammalian injuries and diseases, including but not limited to, nervous system injuries or diseases that may otherwise result in decreased cell or system function.

Description

TECHNICAL FIELD[0001]Without limitation, certain embodiments of the invention relate to induction and application of cell types for the treatment of mammalian nervous system injuries and diseases.BACKGROUND[0002]Certain nervous system injuries, autoimmune diseases affecting the central or peripheral nervous system, and neurodegenerative diseases are characterized by loss of specific cells, or abnormal functions of existing nerve cells, which cause the patient to present with different neurological signs and symptoms and potentially irreversible loss of neurological functions. As one example only, some patients suffering stroke, spinal cord injury, or other neural injury and degeneration experience loss of functioning cell types, or neurological conditions like Parkinson's disease and Alzheimer's disease which in turn results in loss of or abnormal function of system function. Currently therapeutic options for treating and restoring such cell and system functions are limited. Thus, a...

Claims

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Application Information

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IPC IPC(8): A61K35/30A61P25/00A61P25/28C12N5/02
CPCC12N15/113C12N2310/141C12N2330/10C12N2501/65A61K31/7105C12N2501/13C12N2506/1353C12N2510/00C12N5/0619A61P25/00A61P25/28A61P43/00A61K48/005
Inventor BRODIE, CHAYASLAVIN, SHIMON
Owner EXOSTEM BIOTEC LTD
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