Factor involved in latent infection with herpesvirus, and use thereof

a technology of herpesvirus and factor, applied in the field of factor involved in latent infection with herpesvirus, can solve the problems of not being able to identify any specific involvement of latent infection gene or latent infection gene protein, and achieve the effect of regulating latent infection

Inactive Publication Date: 2013-08-22
JAPAN TOBACCO INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0052]A gene or a protein of the present invention is expressed specifically during latent infection with a herpesvirus, and has ability to regulate latent infection and reactivation of a herpesvirus. Further, as described later, it has been shown that an antibody against a protein of the present invention is significantly found in patients with mental disorders. Therefore, determining the presence or absence of the antibody enables objective diagnosis for mental disorders.

Problems solved by technology

However, there has not been identified any latent infection gene or latent infection gene protein specifically involved in diseases.

Method used

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  • Factor involved in latent infection with herpesvirus, and use thereof
  • Factor involved in latent infection with herpesvirus, and use thereof
  • Factor involved in latent infection with herpesvirus, and use thereof

Examples

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examples

1. Identification of Gene Product (mRNA) Encoding Latent Infection Specific Protein SITH-1

[0229]Messenger RNA (mRNA) was separated from those macrophages described in Non-Patent Document 1 that were latently infected with HHV-6, and a reverse transcription reaction was performed using random primers, IE4RB as a primer for reverse transcription of sense transcripts, and IE2FB as a primer for reverse transcription of anti-sense transcripts. Thereafter, the resultant reverse transcripts (cDNA) were amplified by the PCR technique using the primers IE4RB and IE2FB, and the products were further amplified by the double-nested PCR technique using the inner primers IE4RA and IE2FA. FIG. 1 shows (i) the correspondence between the sense transcript (H6LT) of the known mRNA during productive infection and the novel latent infection specific gene and (ii) an open reading frame of the latent infection specific protein SITH-1. For details of the sequence information about SITH-1 and the novel late...

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Abstract

Disclosed are a protein and a gene each of which is a factor involved in latent infection with a herpesvirus. An antibody against the factor was detected in approximately 50% of patients suffering from mental disorders, whereas the antibody was hardly detected in healthy persons. Further, a mouse having SITH-1 introduced therein developed a mental disorder such as a manic-depressive illness or depression-like disorder. Based on these findings, it is possible to provide a method for objectively determining a mental disorder and an animal model of a mental disorder.

Description

[0001]This application is a Divisional of copending application Ser. No. 12 / 679,816 filed on Mar. 24, 2010 and for which priority is claimed under 35 U.S.C. §120, which is a National Phase of PCT International Application No PCT / JP2008 / 067300, filed on Sep. 25, 2008, under 35 U.S.C. §371, which claims priority under 35 U.S.C. 119(a) to Patent Application No. JP 2007-250461, filed on Sep. 27, 2007. The entire contents of all of the above applications are hereby expressly incorporated by reference into the present application.TECHNICAL FIELD[0002]The present invention relates to: a factor involved in latent infection with a herpesvirus; and use thereof. Particularly, the present invention relates to a novel protein which is specifically expressed during latent infection with a herpesvirus; a gene encoding said protein; and use thereof.BACKGROUND ART[0003]Viruses of the family Herpesviridae, each having an overall size of approximately 150 nm to 200 nm, are such that a core protein is ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N33/68
CPCA01K2267/0356C07K14/005C12N7/00C12N2710/10343C12N2710/16522G01N33/6854C12N2740/10043G01N33/6896G01N2333/035G01N2800/304G01N33/6893C12N2710/16571C07K14/03C12N5/10C12N15/63C12N15/79C12N15/11
Inventor KONDO, KAZUHIROKOBAYASHI, NOBUYUKI
Owner JAPAN TOBACCO INC
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