Highly selective sigma receptor ligands

Abstract

Compounds having the general formula II, III, or IVwherein R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle or a radical of an optionally substituted cyclic or acyclic tertiary amine or isoindoline-1,3-dione: R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate, optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N—R, N—Ar, C—R, C—Ar; Z can be either H, O, S, S—R or NR. R groups can be either H, aryls, alkyls, or cycloalkyls; “n” can be 1 to 5 carbons in length and stereoisomers, functional analogs, and pharmaceutically acceptable salts thereof and wherein the moiety bridging R1 and N can be a substituted alkylene, optionally substituted alkenylene or optionally substituted alkynylene and where the alkylene group can include an inserted C3-C5 cycloalkyl group, aromatic, and hetercocyclic group; wherein X′ is halogen, or C1-C4 haloalyl; wherein the Rx is a C1-C5 straight chain or branched chain alkyl or a C1-C4 straight chain or branched chain haloalkyl.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This is a Divisional application of U.S. application Ser. No. 12 / 785,217, filed on May 21, 2010, which is a Continuation-in-part application of U.S. application Ser. No. 12 / 673,486, filed on May 12, 2010, entitled “HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS”, which claims priority of PCT / US08 / 73478, filed Aug. 18, 2008 which claims priority to U.S. Provisional Application No. 60 / 956,249, filed Aug. 16, 2007, the disclosure of all of which is expressly incorporated by reference herein in its entirety.[0002]The subject invention was made with government support under a research project supported by the United States Government in NIDA Grant Numbers DA023205, DA011979, DA013978 and NCRR P20 RR021929 and the government has certain rights in this invention.FIELD OF INVENTION[0003]The present invention relates to the field of compounds which are sigma receptor ligands and methods of use thereof as sigma receptor ligands.BACKGROUND OF THE INVENTION...

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