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Methods, devices, and systems for postconditioning with clot removal

a technology of clot removal and postconditioning, which is applied in the field of postconditioning with clot removal, can solve the problems of providing methods and systems, and the prior art fails to sufficiently address the constraints of arterial space in the brain that limit the positioning of devices and/or systems, so as to facilitate the inflation of balloons, reduce the volumetric flow rate of inflating fluid, and increase the flow of fluid

Inactive Publication Date: 2015-08-20
COGNITION MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016]As described more fully in this specification, embodiments of the present invention include methods for preventing, treating, and / or at least minimizing ischemic stroke and / or reperfusion injury by restoring and / or modulating blood flow, particularly in the cerebral vasculature. The methods, generally referred to as postconditioning, are performed with devices and systems, which are adapted for use in the performance of the controlled restoration and / or modulating blood flow. The devices, systems, and methods described herein make it possible for a clinician to adequately and systematically restore blood flow to ischemic tissue while simultaneously modulating the blood flow to minimize reperfusion injury. Some embodiments of the present invention specifically enable postconditioning in the challenging dimensional constraints of the brain. Some embodiments further enable improved binding with clots and reperfusion by creating an increase within the cross-sectional area between the clot and the blood vessel wall or in the clot itself, particularly for clots that are resistant to the weak engagement of existing thrombectomy devices and / or systems.
[0050]The invention in another embodiment includes a method of preventing and / or treating ischemic stroke in a patient. In this embodiment the steps of the method include: identifying a blood clot in a cerebral blood vessel; inserting an assembly able to prevent, mitigate and / or treat ischemic stroke into the blood vessel, the assembly comprising: a flow restoration member comprising a self-expanding scaffold able to engage a clot in a cerebral blood vessel; and a flow modulation member able to modulate blood flow in a cerebral blood vessel, wherein the members are able to be used simultaneously to prevent, mitigate, reduce and / or treat ischemic stroke: deploying the scaffold to restore blood flow in the cerebral blood vessel; and performing one or more postconditioning cycles with the flow modulation member by reversibly decreasing and increasing the flow of fluid through the blood vessel at least twice.

Problems solved by technology

The prior thrombectomy and / or postconditioning art fail to recognize the importance of, and provide methods and systems for, adequately controlling the restoration of blood flow so as to minimize and / or prevent reperfusion injury.
The prior art also fails to sufficiently address the arterial space constraints in the brain that limit the positioning of devices and / or systems.

Method used

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  • Methods, devices, and systems for postconditioning with clot removal
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Embodiment Construction

[0119]Embodiments of the present invention include methods for preventing, treating, and / or at least minimizing ischemic stroke and / or reperfusion injury by restoring and / or modulating blood flow, particularly in the cerebral vasculature. The methods, generally referred to as postconditioning are performed with devices and systems, which are adapted for use in the performance of the controlled restoration and / or modulating of blood flow. The devices, systems, and methods described herein make it possible for a clinician to adequately and systematically restore blood flow to ischemic tissue while simultaneously modulating the blood flow to minimize reperfusion injury. Some embodiments of the present invention specifically enable postconditioning in the challenging dimensional constraints of the brain. Some embodiments further enable improved binding with clots and reperfusion by creating an increase within the cross-sectional area between the clot and the blood vessel wall or in the ...

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Abstract

New devices, systems, and methods are disclosed for preventing, treating, and / or at least minimizing ischemia and / or reperfusion injury by restoring and / or modulating blood flow, particularly in the cerebral vasculature where blood vessels are narrow and tortuous. These devices, systems, and methods make it possible for a clinician to adequately and systematically restore blood flow to ischemic tissue while simultaneously modulating the blood flow to minimize reperfusion injury.

Description

RELATED APPLICATIONS[0001]This application claims priority to and incorporates by reference the entire contents of U.S. Provisional Application No. 61 / 668,408, filed on Jul. 5, 2012 and U.S. patent application Ser. No. 13 / 844,728 filed on Mar. 15, 2013.TECHNICAL FIELD[0002]The present disclosure relates generally to methods, devices, and systems for treating vascular disorders. More specifically, the present disclosure relates to methods, devices, and systems for restoring blood flow by, e.g., removing blood clots, and / or modulating post-reperfusion blood flow.BACKGROUND OF THE INVENTION[0003]Ischemia, the restriction of blood supply to tissue, may result in tissue damage in a process known as ischemic cascade. Damage includes, but is not limited to, shortage of metabolic requirements (i.e., oxygen and glucose), build-up of metabolic waste products, inability to maintain cell membranes, mitochondrial damage, and eventual leakage of autolysing proteolytic enzymes into the cell and su...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B17/3207A61M25/10
CPCA61B17/12031A61B17/12036A61B17/12109A61B17/12136A61B17/12172A61B17/221A61B2017/22065A61B2017/2215A61F2/966A61B17/3207A61B17/320725A61B2017/22067A61B2017/320716A61F2/82A61F2/844A61F2/86A61F2/95A61M25/0082A61M25/10A61M2025/1095
Inventor TURJMAN, ALEXISBERNSTEIN, JONAH
Owner COGNITION MEDICAL
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