Anti-s100a4 antibody molecules and their uses

a technology of antibody molecules and s100a4, which is applied in the field of anti-s100a4 antibody molecules, can solve the problems of largely unmet metastatic therapy, promote tumour progression, inhibit the biological activity of s100a4, and inhibit the development and growth of tumours

Active Publication Date: 2016-06-09
CANCER RES TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007]Broadly, the present invention is based on the present inventors developing anti-S100A4 antibody molecules that are capable of inhibiting the biological activity of S100A4 in promoting tumour progression and / or in inducing tumour metastasis. The present invention further shows that the antibodies of the present invention are capable of delaying and / or inhibiting tumour development and growth. These properties of the antibodies are demonstrated using in vitro and in vivo assays.

Problems solved by technology

However, while the role of S100A4 in tumour progression and metastasis formation has been studied, it remains the case that anti-metastatic therapy is in a rudimentary state largely unmet by existing therapies.

Method used

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  • Anti-s100a4 antibody molecules and their uses

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Discussion for Further Experimental Examples

[0216]The conclusion from the further in vivo and in vitro experiments described above that neutralization of S100A4 protein by 6B12 antibody not only reduce the metastatic burden in lungs of spontaneous mammary tumour-bearing mice, but also delays the uptake of primary tumours and delays the tumour development. These effects could be associated with the reduction of vessel density and most importantly with the reduction of T cell accumulation at the early pre-malignant stage of tumour development. S100A4 executes its pro-metastatic function attracting T cells and activating signal transduction pathways that alter T cell lineage differentiation pattern. Changes in the cytokine profile resulting from these alterations will lead to modulation of the microenvironment of the organ that will be favourable for tumour and metastasis development.

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Abstract

Anti-S100A4 antibody molecules that are capable of inhibiting the biological activity of S100A4 in promoting tumour progression and/or in inducing tumour metastasis are described. The antibody molecules are also useful in the treatment of inflammatory conditions. The properties of the antibodies are demonstrated using in vitro and in vivo assays.

Description

FIELD OF THE INVENTION[0001]The present invention relates to anti-S100A4 antibody molecules and their medical uses, and more particularly to anti-S100A4 antibody molecules that are capable of inhibiting the biological activity of S100A4, for example in promoting tumour progression and / or in inducing tumour metastasis, and their uses in the treatment of cancer, in particular metastatic cancer, and inflammatory conditions. Conjugates of the antibody molecules and their uses are also provided.BACKGROUND OF THE INVENTION[0002]More that 90% of cancer-related deaths are caused by dissemination of cancer cells to distant organs with subsequent formation of secondary tumours. In contrast to the primary tumour, metastasis is largely incurable because of its systemic nature and its frequent association with resistance to existing therapeutic agents. The better understanding of the mechanisms of metastatic spread of cancer cells and the pathways involved in this process had identified new targ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07K16/18A61K45/06G01N33/574A61K39/395
CPCC07K16/18A61K39/39558A61K45/06G01N33/57415C07K2317/76A61N2005/1098C07K2317/24A61K2039/505C07K2317/92G01N2333/4727C07K2317/34A61P29/00A61P35/00C07K16/30C07K2317/30C07K2317/33
Inventor KLINGELHOFER, JORGAMBARTSUMIAN, NOONAGRIGORIAN, MARIAMLUKANIDIN, EUGENE
Owner CANCER RES TECH LTD
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