Modular Extracorporeal Systems and Methods for Treating Blood-Borne Diseases
a technology of extracorporeal systems and blood-borne diseases, applied in the field of modules of extracorporeal systems and methods for treating blood-borne diseases, can solve the problems of limited pharmacological intervention, inability to effectively treat blood-borne diseases, so as to minimize the toxicity to the patient, the effect of efficient and effective treatmen
Inactive Publication Date: 2016-09-01
SOMERSET GROUP ENTERPRISES
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Benefits of technology
The invention provides systems and methods for efficiently and effectively treating blood-borne diseases while minimizing toxicity to the patient. This is achieved by removing blood from the patient, treating it with hydrostatic pressure, a pulsed electrical field, or other methods, and then returning it to the patient. The invention also includes methods for developing new antimicrobial drugs and evaluating their efficacy. Additionally, the invention allows for the treatment of resistant pathogens and the use of existing drugs in new ways. Overall, the invention provides a more effective and safe way to treat blood-borne diseases.
Problems solved by technology
The treatment of blood-borne disease by pharmacological intervention is limited by pathogen resistance and drug toxicity; the drugs used to attack pathogens are often also toxic to healthy human cells and tissues.
Pharmaceutical intervention is also limited by the constant and rapid evolution of pathogens, especially bacteria, to adapt and become resistant to drugs.
However, most large pharmaceutical companies in the United States have abandoned basic research and development of new antibiotic drugs and are focusing their research and development efforts elsewhere, despite the ever growing problem of antibiotic resistance.
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[0052]It is understood that the invention is not limited to the particular methodology, protocols, and mechanical features, etc., described herein, as these may vary as the skilled artisan will recognize. It is also to be understood that the terminology used herein is used for the purpose of describing particular embodiments only, and is not intended to limit the scope of the invention. It also is be noted that as used herein and in the appended claims, the singular forms “a,”“an,” and “the” include the plural reference unless the context clearly dictates otherwise. Thus, for example, a reference to “a drug” is a reference to one or more drugs and equivalents thereof known to those skilled in the art.
[0053]Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art to which the invention pertains. The embodiments of the invention and the various features and advantageous details thereof ar...
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Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.
Description
PRIOR RELATED APPLICATIONS[0001]This application is a divisional application of U.S. patent application Ser. No. 13 / 346,321, filed Jan. 9, 2012, which claims priority to U.S. provisional application No. 61 / 430,634, filed Jan. 7, 2011, the contents of each which are hereby incorporated by reference in their entirety.BACKGROUND OF THE INVENTION[0002]The treatment of blood-borne disease by pharmacological intervention is limited by pathogen resistance and drug toxicity; the drugs used to attack pathogens are often also toxic to healthy human cells and tissues. Pharmaceutical intervention is also limited by the constant and rapid evolution of pathogens, especially bacteria, to adapt and become resistant to drugs. Methicillin-resistant Staphylococcus aureus (“MRSA”) is especially pernicious and is gaining national and worldwide attention as a priority for disease control efforts. A 2007 report in Emerging Infectious Diseases, a publication of the Centers for Disease Control and Preventio...
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IPC IPC(8): A61M1/36A61K35/14G01N33/50
CPCA61M1/3672A61M1/3678A61M1/3681G01N2800/26A61M1/369G01N33/5091A61K35/14A61M1/3693A61M1/1698A61M1/32A61M1/36A61M1/3633A61M1/3687A61M2205/05A61N5/00A61M2205/053A61M2205/75A61M1/3683A61M1/3686A61M2202/0225A61M2202/20A61M2202/0208A61M1/3609A61M1/3472A61M1/3486A61P19/00A61P31/04A61M2202/0266A61M2202/0275A61M2202/025A61M1/16A61M1/14A61M2202/0258A61M1/3621A61M2202/0291A61M2202/0233
InventorGREENBERG, DAVID G.PURITZ, SCOTTKOUTCHMA, TATIANAWALTERSPIEL, JUAN N.
OwnerSOMERSET GROUP ENTERPRISES