Method for treating a cancer with a mixed ligand gold(III) complexes as Anti-cancer agents
a technology of mixed ligands and anti-cancer agents, which is applied in the field of pharmaceutical compounds, can solve problems such as unstable gold(iii) complexes
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example 1
Synthesis of Gold(III) Complexes
[0117]Sodium tetrachloroaurate(III) dihydrate NaAuCl4.2H2O and 1,3-propylenediamine (pn) were purchased from Sigma-Aldrich. Ligands, cis-1,2-diaminocyclohexane (cis-DACH), trans-(±)-1,2-diaminocyclohexane (trans-(±)-DACH) and (S,S)-(+)-diaminocyclohexane ((S,S)-DACH) were purchased from Aldrich. Absolute C2HsOH, CH3OH, D2O and DMSO-d6 were obtained from Fluka Chemicals Co. All other reagents as well as solvents were obtained from Aldrich Chemical Co., and used as received.
[0118]Mixed ligand gold(III) chloride compounds, cis-1,2-diaminocyclohexane(1,3-propylenediamine)gold(III) chloride, [(pn)Au {cis-(1,2-DACH)} ]Cl3 1, trans-(±)-1,2-diaminocyclohexane(1,3-propylenediamine)gold(III) chloride, [(pn)Au {(trans-(±)-(1,2-DACH)}]Cl3 2, and (S,S)-(+)-1,2-diaminocyclohexane(1,3-propylenediamine)gold(III) chloride [(pn)Au {(S,S)-(+)-(1,2-DACH)} ]Cl3 3, were synthesized using one mole of sodium tetrachloroaurate(III) dihydrate NaAuCl4.2H2O with one mole of 1,3-...
example 2
Electronic Spectra
[0120]Electronic spectra were obtained for the gold(III) complexes using the Lambda 200, Perkin-Elmer UV-Vis spectrometer. UV-Vis spectroscopy was used to determine the stability of the complexes in a physiological buffer (40 mM phosphate, 4 mM NaCl, pH 7.4). Electronic spectra were recorded on freshly prepared of each complex in buffer solution at room temperature. Then, their electronic spectra were monitored over 3 days at 37° C. The UV-Vis absorption data is shown in Table 2.
TABLE 2λmax values derived from UV-Vis spectrafor gold(III) complexes 1, 2 and 3.Complexλmax (nm)NaAuCl4293133223393341
[0121]The gold(III) complexes 1, 2 and 3 dissolved in a reference buffered phosphate solution exhibit intense absorptions in the range 332-341 nm, which are assigned to ligand-to-metal charge-transfer (LMCT) transitions characteristically associated to the gold(III) center [Esumi K, Nawa M, Aihara N, Usui K (1998) New J. Chem. 20:719-720—incorporated herein by reference in ...
example 3
Mid and Far-IR Studies
[0124]The IR spectra of the ligands and their gold(III) complexes were recorded on a Perkin-Elmer FT-IR 180 spectrophotometer using KBr pellets over the range 4000-400 cm−1. The selected IR frequencies are given in Table 3.
TABLE 3IR frequencies, ν(cm−1) for cyclohexanediamine-gold(III)-propylenediamine complexes.Complexν(N—H)νshiftν(C—N)νshiftRefs.pn3357 m, 3282 m1093 wd(pn)AuCl33447 br1271178 s 85dcis-1,2-(DACH)3356 m, 3286 m3092s e[cis-1,2-(DACH)AuCl2]Cl3414 w931183 s 91e1 3426br, 3106 br105a, 107b1163w 71a, 70bctrans-(±)-1,2-(DACH)3348 m, 3271 m, 3183 m1082 me[trans-(±)-1,2-(DACH)AuCl2]Cl3485 w, 3420 w, 3384 w137, 149, 2011175 m93e23452br, 3112 br131a, 133b1184 m92a, 91bc(S,S)-(+)-1,2-(DACH)3340 m, 3252 m, 3167 m1082 me[(S,S)-(+)-1,2-(DACH)AuCl2]Cl3604 m, 3340 m, 3306 m, 3168 m132, 27 1171 m89e33444br, 3118 123a, 125b1186 m94a, 93bcawith respect to DACH,bwith respect to pn,c this work,d Al-Maythalony B A et al. (2009) Inorg. Chim. Acta. 362: 3109-3113 - ...
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