Mechanical Separator for a Biological Fluid
a biological fluid and mechanical separator technology, applied in the field of mechanical separators for biological fluids, can solve the problems of special manufacturing equipment, adverse chemical reaction with the gel interface, limited shelf life of the gel-based separator product,
Inactive Publication Date: 2017-09-21
BECTON DICKINSON & CO
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- Application Information
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Benefits of technology
The separator effectively separates blood samples into serum and plasma with reduced cross-contamination, stability during storage and shipping, and simplified manufacturing, while maintaining sample integrity and compatibility with standard equipment.
Problems solved by technology
However, current polyester gel serum separation tubes require special manufacturing equipment to both prepare the gel and fill the tubes.
Moreover, the shelf-life of the gel-based separator product is limited.
Accordingly, if certain drugs are present in the blood sample when it is taken, an adverse chemical reaction with the gel interface can occur.
Furthermore, if an instrument probe is inserted too deeply into a collection container, then the instrument probe may become clogged if it contacts the gel.
This can result in sample pooling under the closure, device pre-launch in which the mechanical separator prematurely releases during blood collection, trapping of a significant quantity of fluid phases, such as serum and plasma, poor sample quality, and / or barrier failure under certain circumstances.
Furthermore, previous mechanical separators are costly and complicated to manufacture due to the complicated multi-part fabrication techniques.
Method used
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[0033]For purposes of the description hereinafter, the words “upper”, “lower”, “right”, “left”, “vertical”, “horizontal”, “top”, “bottom”, “lateral”, “longitudinal”, and like spatial terms, if used, shall relate to the described embodiments as oriented in the drawing figures. However, it is to be understood that many alternative variations and embodiments may be assumed except where expressly specified to the contrary. It is also to be understood that the specific devices and embodiments illustrated in the accompanying drawings and described herein are simply exemplary embodiments of the invention.
[0034]The separation assembly of the present invention is intended to provide separation of a sample into higher and lower density phase components, as will be discussed herein. For example, the present separation assembly can be used to provide a separation of serum or plasma from whole blood through the use of differential buoyancy to cause a sealing area to contract when submerged in a ...
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A separation assembly for separation of a fluid into first and second parts is disclosed. A container has a first end, a second end, and a sidewall extending therebetween defining an interior, the container defining a longitudinal axis between the first end and the second end. A separator body is disposed within the interior having a through-hole defined therethrough. The separator body includes a first part, and a second part interfaced with the first part, wherein the separator body is transitionable from a first position wherein the through-hole is provided in fluid-receiving alignment with the first end of the container, to a second position wherein the through-hole is provided substantially perpendicular to the longitudinal axis of the container. In the first position, a through-axis of the through-hole of the separator body is in a plane that is not parallel with a plane containing the longitudinal axis of the container.
Description
CROSS-REFERENCE TO RELATED APPLICATION[0001]The present application is a continuation of U.S. patent application Ser. No. 14 / 629,643, entitled “Mechanical Separator for a Biological Fluid” filed Feb. 24, 2015, which claims priority to U.S. Provisional Patent Application No. 62 / 079,216, entitled “Mechanical Separator for a Biological Fluid” filed Nov. 13, 2014, the entire disclosures of each of which are hereby incorporated by reference.BACKGROUND OF THE INVENTION[0002]Field of the Invention[0003]The subject invention relates to a device for separating higher and lower density fractions of a fluid sample. More particularly, this invention relates to a device for collecting and transporting fluid samples whereby the device and fluid sample are subjected to centrifugation in order to cause separation of the higher density fraction from the lower density fraction of the fluid sample.[0004]Description of Related Art[0005]Diagnostic tests may require separation of a patient's whole blood ...
Claims
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IPC IPC(8): B01L3/00G01N33/49
CPCB01L2300/06B01L2300/0832G01N33/491B01L3/50215B01L2400/0644
InventorLOSADA, ROBERT J.NAIR, ARUN U.
OwnerBECTON DICKINSON & CO