Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody

a technology of specific antibodies and crohn's disease, which is applied in the field of methods for treating crohn's disease with antibodies, can solve the problems of affecting the response of a large percentage of the target patient population, or losing the response over tim

Inactive Publication Date: 2019-09-05
JANSSEN BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the introduction of biologic agents has significantly improved the clinical management of patients with moderately to se...

Method used

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Preclinical Evidence Implicating IL-23 as a Target in Crohn's Disease

[0195]Genetic and animal model studies have explored the contribution of IL-12 and IL-23 in driving the pathophysiology of Crohn's disease. The results indicate that IL-23 plays a predominant role in inflammatory bowel disease (IBD) and emerging evidence suggests that blocking IL-23 alone may be a more effective strategy than blocking both IL-12 and IL-23.

[0196]Initial observations from genetic and animal model data suggest that Crohn's disease is mediated by IL-12 and / or IL-23, potentially through the Th1 and Th17 pathways they induce, respectively. However, increasing evidence suggests a predominant role for IL-23 in Crohn's disease. Genome-wide association studies identified polymorphisms in the IL-23R gene that are associated with Crohn's disease. The role of IL-23 in driving intestinal inflammation has been shown in several mouse models. Mice treated with anti-IL-23 antibodies exhibited attenuated inflammation...

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Abstract

A method of treating Crohn's disease in a patient administers an IL-23 specific antibody, e.g., guselkumab, at an initial intravenous dose and subsequence subcutaneous doses.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to United States Provisional Application Ser. No. 62 / 638,624, filed 5 Mar. 2018. The entire contents of the aforementioned application are incorporated herein by reference in their entireties.SEQUENCE LISTING[0002]The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on 1 Mar. 2019 is named JBI5153USNP1SEQLIST.txt and is 79,744 bytes in size.FIELD OF THE INVENTION[0003]The present invention concerns methods for treating Crohn's Disease with an antibody that binds the human IL-23 protein. In particular, it relates to dosing regimens for administration of an anti-IL-23 specific antibody and specific pharmaceutical compositions of an antibody, e.g., guselkumab.BACKGROUND OF THE INVENTION[0004]Interleukin (IL)-12 is a secreted heterodimeric cytokine comprised of 2 disulfide-li...

Claims

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Application Information

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IPC IPC(8): A61K38/17C07K16/24A61P1/00A61P37/06
CPCA61K38/1793C07K16/244A61P1/00A61K2039/57A61K2039/545A61K2039/505C07K2317/76A61P37/06A61K9/08A61K47/26A61K47/22A61K2039/54C07K2317/565
Inventor ADEDOKUN, OMONIYICHAN, DAPHNECHEN, YANGSZAPARY, PHILIPPE
Owner JANSSEN BIOTECH INC
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