Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Tissue molecular signatures of kidney transplant rejections

a kidney transplant and molecular signature technology, applied in biochemistry apparatus and processes, instruments, ict adaptation, etc., can solve problems such as hampered the therapeutic potential of kidney transplantation

Inactive Publication Date: 2020-12-31
THE SCRIPPS RES INST +1
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, graft losses due to allograft dysfunction or other uncertain etiologies have greatly hampered the therapeutic potential of kidney transplantation.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tissue molecular signatures of kidney transplant rejections
  • Tissue molecular signatures of kidney transplant rejections
  • Tissue molecular signatures of kidney transplant rejections

Examples

Experimental program
Comparison scheme
Effect test

example 1

ially Expressed Genes Associated with Kidney Transplant Rejections

[0121]This Example describes global analysis of gene expressions in kidney transplant patients with different types of rejections or injuries.

[0122]A total of biopsy-documented 274 kidney biopsy samples from the Transplant Genomics Collaborative Group (TGCG) were processed on the Affymetrix HG-U133 PM only peg microarrays. The 274 samples that were analyzed comprised of 4 different phenotypes: Acute Rejection (AR; n=75); Acute Dysfunction No Rejection (ADNR; n=39); Chronic Allograft Nephropathy (CAN; n=61); and Transplant Excellent (TX; n=99).

[0123]Signal Filters: To eliminate low expressed signals we used a signal filter cut-off that was data driven, and expression signals

[0124]4-Way AR / ADNR / CAN / TX classifier: We first did a 4 way comparison of the AR, ADNR, CAN and TX samples. The samples comprised of four d...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
immune reactivityaaaaaaaaaa
blood pressureaaaaaaaaaa
compatibilitiesaaaaaaaaaa
Login to View More

Abstract

By a genome-wide gene analysis of expression profiles of known or putative gene sequences in kidney biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing kidney transplantation patients who have Acute Rejection (AR), Acute Dysfunction No Rejection (ADNR), Chronic Allograft Nephropathy (CAN), or Transplant Excellent / Normal (TX). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of transplantation patients.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 15 / 313,215 (filed Nov. 22, 2016, now pending), which is a § 371 U.S. national phase filing of PCT International Patent Application No. PCT / US2015 / 032,195 (filed May 22, 2015, now expired), which claims the benefit of priority to U.S. application Ser. No. 14 / 481,167 (filed Sep. 9, 2014, now abandoned); to International Application No. PCT / US2014 / 054735 (filed Sep. 9, 2014, now expired); to U.S. Provisional Application No. 62 / 029,038 (filed Jul. 25, 2014, now expired); to U.S. Provisional Application No. 62 / 001,889 (filed May 22, 2014, now expired); to U.S. Provisional Application No. 62 / 001,902 (filed May 22, 2014, now expired); and to U.S. Provisional Application No. 62 / 001,909 (filed May 22, 2014, now expired). Each of the aforementioned priority applications is incorporated by reference herein in its entirety.STATEMENT CONCERNING GOVERNMENT SUPPORT[0002]This inventio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/6883G16H50/30G16B25/00G16B40/00G01N33/68C12Q1/6881G16H20/40G16B25/10G16B40/20
CPCG16B25/00G16H50/30C12Q2600/112G16B40/00C12Q2600/16C12Q2600/158G16H20/40G01N33/6893Y02A90/10C12Q2600/136C12Q2537/165C12Q1/6881C12Q2600/118C12Q1/6883G01N2800/245G16B40/20G16B25/10G16B20/00
Inventor SALOMON, DANIEL R.KURIAN, SUNILABECASSIS, MICHAEL M.
Owner THE SCRIPPS RES INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com