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Nicotinamide adenine dinucleotide (NAD) compositions, methods of manufacturing thereof, and methods of use thereof

Pending Publication Date: 2022-11-10
SOVIDA SOLUTIONS LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes using certain compositions to improve the look of skin.

Problems solved by technology

Despite the above, the uses of NAD+, its precursors, and / or its derivatives is limited due to their limited stability.
Skin Pharmacol. Physiol. 2007; 20:37-42), however, long term stability outside refrigerated conditions remains a challenge.

Method used

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  • Nicotinamide adenine dinucleotide (NAD) compositions, methods of manufacturing thereof, and methods of use thereof
  • Nicotinamide adenine dinucleotide (NAD) compositions, methods of manufacturing thereof, and methods of use thereof
  • Nicotinamide adenine dinucleotide (NAD) compositions, methods of manufacturing thereof, and methods of use thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

Concentrate of NAD+ in Glycerin / Water, Preservative-Free, Self-Preserving

[0186]Liposomal concentrate of NAD+ in glycerin / water, according to embodiments of the instant disclosure, was prepared in Batch Preparation 1. Batch Preparation 1 had the concentrations indicated in the Table below.

Batch Preparation 1 CompositionConcentration (wt %)ComponentCAS No.EINECS No.Preparation 1Preparation 2Glycerin56-81-5200-289-5ad 100% 62%Water7732-18-5231-791-222.9% 22%Nicotinamide53-84-9200-184-45.0%5.0%AdenineDinucleotidePentylene Glycol5343-92-0226-285-34.7%5.0%Lecithin8030-76-0310-129-74.0%5.0%8002-43-5232-307-2Sodium1310-73-2215-185-50.3% HydroxideTocopherol1406-66-2604-195-90.020%

[0187]Batch Preparation 1 had a fluid appearance and a beige turbid color. The pH value of Batch Preparation 1 at 25° C. ranged from 5.5-7 (per SOP method 0009), the density (per SOP method 0007) at 20° C. was 1.175-1.195 g / cm3, the refractive index (per SOP method 0008) at 20° C. was 1.435-1.455, a water content (p...

example 2

Study

[0190]Three Batch preparations are prepared as follows:[0191]Batch Preparation 1—Liposome (5% NAD+ in glycerin+water) prepared according to Example 1[0192]Batch Preparation 2—a mixture of 5% NAD+ in glycerin+water without formation of a liposome[0193]Batch Preparation 3-5% NAD+ in water with a preservative (0.15% potassium sorbate and 0.3% sodium benzoate), pH adjusted to 4.2 with NaOH, and without any additional components

[0194]Samples from each Batch preparation are stored at the following temperatures:[0195]Fridge at 4° C.-8° C.[0196]Room Temperature (RT) at about 21° C.-25° C.[0197]Oven at about 40° C.

[0198]Samples from each Batch preparation at each of the temperatures are analyzed after the following storage duration time points:[0199]T=0 (before storage initiation)[0200]T=1 (after one month of storage)[0201]T=3 (after three months of storage)[0202]T=6 (after six months of storage)[0203]T=12 (after twelve months of storage)

[0204]The stability study is performed without hu...

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Abstract

Disclosed herein are compositions that include nicotinamide adenine dinucleotide (NAD), precursors thereof, derivatives thereof, or mixtures thereof encapsulated in a liposome, wherein the compositions exhibit enhanced chemical, physical, and / or microbial storage stability at a variety of storage temperatures. In certain embodiments, the compositions are stable and have positive permeability and senescence results. Also disclosed herein are methods for preparing such compositions and methods of using such compositions.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present application claims priority to U.S. Provisional Patent Application No. 63 / 183,174 filed on May 4, 2021, the contents of which are incorporated herein by reference in their entirety.FIELD OF THE DISCLOSURE[0002]The present disclosure relates to compositions that include nicotinamide adenine dinucleotide, derivatives thereof, precursors thereof, or a combination thereof. In certain embodiments, the compositions are stable and have positive permeability and senescence results. The present disclosure also relates to methods of preparing such compositions, and to methods of using such compositions.BACKGROUND OF THE DISCLOSURE[0003]The oxidized form of extracellular β-nicotinamide adenine dinucleotide (NAD+) is a very important cofactor for many redox reactions in living cells and a substrate for numerous enzymes1 (1 Kim U H, Han M K, Park B H, Kim H R, An NH; Function of NAD glycohydrolase in ADP-ribose uptake from NAD by human ery...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/7084A61P17/00A61K47/10A61K9/127A61K47/02A61K47/22A61K47/24
CPCA61K31/7084A61P17/00A61K47/10A61K9/127A61K47/02A61K47/22A61K47/24A61K9/1272A61K9/0014A61K9/0019A61K9/0056A61K9/1271
Inventor HOLZMEISTER, JOHANNESERLE, HANNS-EBERHARD
Owner SOVIDA SOLUTIONS LTD