External preparation of Fexofenadine

Abstract

An exterior-applied Feisuofeinading for preventing and treating the anaphylaxia and inflammation without untoward effect is disclosed.

Description

Technical field

[0001] The invention belongs to the technology of pharmaceutical preparations. Background technique

[0002] In recent years, due to climate and environmental changes, various harmful gases, dust and other pollution sources have emerged in large numbers, which have become allergens that cause people to have various allergic reactions. Seasonal changes, field work, pollen allergies, inhalation of harmful gases and dust particles, etc., have caused more and more people to suffer from various types of allergic diseases, such as allergic rhinitis, urticaria, skin redness, itching, rashes, etc. Red spots and asthma caused by allergens are very common. Therefore, it is very important to develop drugs for the treatment of allergic diseases.

[0003] Fexofenadine was developed by (Germany) Hoechst Marion Roussel, first listed in the United States in 1996, and listed in the UK in March 1997. It is an orally effective third-generation antihistamine that selectively i...

Examples

preparation example Construction

[0025] Preparation of antiserum: Take 8 healthy rats weighing 90-100g, and intramuscularly inject them with Na 2 SO 4 Ovalbumin (10mg / kg) recrystallized 3-5 times, and intraperitoneal injection of pertussis triple vaccine 2×10 10 / Only. 10-14 days after the sensitization, the animals were sacrificed to collect blood, and the serum was separated by low-speed centrifugation, and stored in a -40°C refrigerator for later use.

[0026] Passive skin sensitization and antigen challenge: Another 80 healthy rats weighing 150-200 g were randomly divided into model control group, high-dose liniment group, low-dose liniment group, high-dose ointment group, and low-dose ointment group according to body weight. Dose group, cetirizine ointment high-dose group, cetirizine ointment low-dose group and gavage control group. The hair on the back of the rat was cut off under anesthesia, and the diluted antiserum (1:6) was intradermally injected into the back of the rat for sensitization, and a ...

Embodiment 1

[0052] fexofenadine liniment

[0053] Fexofenadine 120g

[0054] Ethanol 35ml

[0055] Propylene glycol 180ml

[0056] Tween 80 2g

[0057] Add phosphate buffered saline (PBS) to 1000ml

[0058] Preparation Process:

[0059] First dissolve fexofenadine in the prescribed amount of ethanol, propylene glycol and Tween 80, and then add the prescribed amount of phosphate buffer saline (PBS).

Embodiment 2

[0061] fexofenadine liniment

[0062] Fexofenadine 60g

[0063] Ethanol 200ml

[0064] Propylene glycol 500ml

[0065] Add distilled water to 1000ml

[0066] Preparation Process:

[0067] Dissolve fexofenadine in the prescribed amount of ethanol and propylene glycol, and then add distilled water to 1000ml.

[0068] The liniment prepared in embodiment 1 and embodiment 2 is packed in a specific container (sprayer or atomizer), and can be used as a spray.

Technical field

[0001] The invention belongs to the technology of pharmaceutical preparations. Background technique

[0002] In recent years, due to climate and environmental changes, various harmful gases, dust and other pollution sources have emerged in large numbers, which have become allergens that cause people to have various allergic reactions. Seasonal changes, field work, pollen allergies, inhalation of harmful gases and dust particles, etc., have caused more and more people to suffer from various types of allergic diseases, such as allergic rhinitis, urticaria, skin redness, itching, rashes, etc. Red spots and asthma caused by allergens are very common. Therefore, it is very important to develop drugs for the treatment of allergic diseases.

[0003] Fexofenadine was developed by (Germany) Hoechst Marion Roussel, first listed in the United States in 1996, and listed in the UK in March 1997. It is an orally effective third-generation antihistamine that selectively i...

Examples

preparation example Construction

[0025] Preparation of antiserum: Take 8 healthy rats weighing 90-100g, and intramuscularly inject them with Na 2 SO 4 Ovalbumin (10mg / kg) recrystallized 3-5 times, and intraperitoneal injection of pertussis triple vaccine 2×10 10 / Only. 10-14 days after the sensitization, the animals were sacrificed to collect blood, and the serum was separated by low-speed centrifugation, and stored in a -40°C refrigerator for later use.

[0026] Passive skin sensitization and antigen challenge: Another 80 healthy rats weighing 150-200 g were randomly divided into model control group, high-dose liniment group, low-dose liniment group, high-dose ointment group, and low-dose ointment group according to body weight. Dose group, cetirizine ointment high-dose group, cetirizine ointment low-dose group and gavage control group. The hair on the back of the rat was cut off under anesthesia, and the diluted antiserum (1:6) was intradermally injected into the back of the rat for sensitization, and a ...

Embodiment 1

[0052] fexofenadine liniment

[0053] Fexofenadine 120g

[0054] Ethanol 35ml

[0055] Propylene glycol 180ml

[0056] Tween 80 2g

[0057] Add phosphate buffered saline (PBS) to 1000ml

[0058] Preparation Process:

[0059] First dissolve fexofenadine in the prescribed amount of ethanol, propylene glycol and Tween 80, and then add the prescribed amount of phosphate buffer saline (PBS).

Embodiment 2

[0061] fexofenadine liniment

[0062] Fexofenadine 60g

[0063] Ethanol 200ml

[0064] Propylene glycol 500ml

[0065] Add distilled water to 1000ml

[0066] Preparation Process:

[0067] Dissolve fexofenadine in the prescribed amount of ethanol and propylene glycol, and then add distilled water to 1000ml.

[0068] The liniment prepared in embodiment 1 and embodiment 2 is packed in a specific container (sprayer or atomizer), and can be used as a spray.

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