Composition containing sesamins and epigallocatechin gallate

Abstract

The present invention aims to provide a means for promoting the absorption of sesamins in the body. By using sesamins in combination with epigallocatechin gallate, the absorption of sesamins in the body can be promoted.

Description

technical field

[0001] The present invention relates to a composition for promoting the in vivo absorption of sesamin, an in vivo absorption enhancer of sesamin, and food, drink or pharmaceuticals using the same. Background technique

[0002] Sesamin is a type of lignan compounds contained in sesame. Among them, sesamin and episesamin as its stereoisomer have been reported: blood cholesterol lowering effect and blood neutral lipid lowering effect, liver function improvement effect, active oxygen scavenging effect, Δ5 desaturase inhibition Various physiological activities such as antihypertensive effect, lipid peroxidation production inhibitory effect, antihypertensive effect, drunkenness prevention effect, and breast cancer inhibitory effect (Patent Document 1).

[0003] However, lignan compounds including sesamin are almost insoluble in water, and are soluble only to some extent in organic solvents that can be used for medicine or food. Due to such poor solubility, there ...

Examples

Embodiment 1

[0059] Example 1 Effects of Epigallocatechin Gallate (EGCG) on the In vivo Absorption of Sesamins

[0060] To investigate the influence of EGCG on the in vivo absorbability of sesamin, and in order to investigate the relevance of the antioxidant effect of EGCG, ascorbic acid (vitamin C or VC), which is a representative antioxidant, was used to investigate the effect on sesamin. The effect of absorbability in the body is compared with the results when using EGCG and the control.

[0061] SD (IGS) male rats (8 weeks old) were purchased from Charles River Corporation, Japan, and domesticated in the test environment for 1 week, and the animals showing smooth development were selected for the test. The rats after one night of fasting were divided into 3 groups, 4 in each group, and a 1: 1 mixture of distilled water 5ml / kg and sesamin and episesamin (purchased from Takemoto Oil Co., Ltd.: hereinafter also referred to as " The olive oil solution (10mg / 3ml) 3ml / kg of sesamin class...

Embodiment 2

[0078] Embodiment 2: prescription example

preparation example 1

[0079] (Preparation Example 1) Granules

[0080]

[0081] After uniformly mixing the above powders, add 100 ml of 10% hydroxypropylcellulose-ethanol solution, knead, extrude, and dry according to the usual method to obtain granules.

technical field

[0001] The present invention relates to a composition for promoting the in vivo absorption of sesamin, an in vivo absorption enhancer of sesamin, and food, drink or pharmaceuticals using the same. Background technique

[0002] Sesamin is a type of lignan compounds contained in sesame. Among them, sesamin and episesamin as its stereoisomer have been reported: blood cholesterol lowering effect and blood neutral lipid lowering effect, liver function improvement effect, active oxygen scavenging effect, Δ5 desaturase inhibition Various physiological activities such as antihypertensive effect, lipid peroxidation production inhibitory effect, antihypertensive effect, drunkenness prevention effect, and breast cancer inhibitory effect (Patent Document 1).

[0003] However, lignan compounds including sesamin are almost insoluble in water, and are soluble only to some extent in organic solvents that can be used for medicine or food. Due to such poor solubility, there ...

Examples

Embodiment 1

[0059] Example 1 Effects of Epigallocatechin Gallate (EGCG) on the In vivo Absorption of Sesamins

[0060] To investigate the influence of EGCG on the in vivo absorbability of sesamin, and in order to investigate the relevance of the antioxidant effect of EGCG, ascorbic acid (vitamin C or VC), which is a representative antioxidant, was used to investigate the effect on sesamin. The effect of absorbability in the body is compared with the results when using EGCG and the control.

[0061] SD (IGS) male rats (8 weeks old) were purchased from Charles River Corporation, Japan, and domesticated in the test environment for 1 week, and the animals showing smooth development were selected for the test. The rats after one night of fasting were divided into 3 groups, 4 in each group, and a 1: 1 mixture of distilled water 5ml / kg and sesamin and episesamin (purchased from Takemoto Oil Co., Ltd.: hereinafter also referred to as " The olive oil solution (10mg / 3ml) 3ml / kg of sesamin class...

Embodiment 2

[0078] Embodiment 2: prescription example

preparation example 1

[0079] (Preparation Example 1) Granules

[0080]

[0081] After uniformly mixing the above powders, add 100 ml of 10% hydroxypropylcellulose-ethanol solution, knead, extrude, and dry according to the usual method to obtain granules.

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