Hydroxypropyl-beta-cyclodextrin hemostatic gauze and preparation method thereof

Abstract

The invention discloses hydroxypropyl-beta-cyclodextrin hemostatic gauze. The hydroxypropyl-beta-cyclodextrin hemostatic gauze is characterized by being prepared from the following raw materials in parts by weight: 3-5 parts of luffa leaves, 1-2 parts of cacumen biotae, 1-2 parts of sangusis draconis, 1-2 parts of mock strawberry, 0.5-1 part of pine pollen, 6-8 parts of hydroxypropyl-beta-cyclodextrin, 6-8 parts of gelatin, 3-5 parts of sodium alginate, 0.1-0.2 part of polysorbate-80, 0.5-1 part of caprylic capric triglyceride, 2-4 parts of sodium carboxymethylcellulose, 1-2 parts of auxiliary materials, and 200-250 parts of water. The soluble hemostatic gauze disclosed by the invention is collaboratively prepared from natural high polymer materials of hydroxypropyl-beta-cyclodextrin and the like, is fast in hemostatic effect, is capable of effectively promoting wound healing, is good in antibacterial effect, is easily absorbed by human body, is good in biocompatibility, and is free from toxic or side effects; the soluble hemostatic gauze is capable of resisting bacteria in a broad spectrum, and diminishing inflammation and easing pain by extracting and compounding natural plant effective ingredients, has a controlled-release function, effectively prolongs the action time, and achieves a better use effect.

Description

technical field

[0001] The invention relates to the field of medicine, in particular to a hydroxypropyl-β-cyclodextrin hemostatic gauze and a preparation method thereof. Background technique

[0002] With the continuous progress of medical technology, new medical materials and related technologies have been well developed. Among them, the development and improvement of hemostatic materials are beneficial to improve the problems of bleeding and bleeding during surgery, which is of great significance and has become a hot research topic in the field of medicine. Traditional hemostatic gauze is generally made of cotton, linen, etc., which has problems such as poor antibacterial and bacteriostatic ability, gauze fibers easily lead to foreign body rejection, affecting wound healing, and easy adhesion to wound tissue during use, causing secondary damage. The generated waste has a complicated treatment process and is easy to pollute the environment.

[0003] Soluble hemostatic gau...

Examples

Embodiment Construction

[0020] Non-limiting examples of the present invention are as follows:

[0021] A hydroxypropyl-β-cyclodextrin hemostatic gauze is prepared from the following weight (kg) components:

[0022] Luffa leaf 4, Arborvitae leaf 1.5, Draconis 1.5, Snakeberry 1.5, Pine pollen 0.8, Hydroxypropyl-β-cyclodextrin 7, Gelatin 7, Sodium alginate 4, Polysorbate-80 0.15, Caprylic acid Glycerides 0.8, sodium carboxymethyl cellulose 3, excipients 1.5, water 200;

[0023] Among them, the auxiliary materials are made from the following weight (kg) raw materials:

[0024] Soy Lecithin 0.8, Glycerin 3, Macrogol 1.5, Bletilla striata Ultrafine Powder 1.5, Mannitol 3, Chlorhexidine Gluconate 1.5, Vitamin C 1.5, Water 18;

[0025] Preparation method of excipients:

[0026] Add soybean lecithin into water at 60°C and stir at 1000 r / min for 1 h, then add glycerin, polyethylene glycol, Bletilla striata superfine powder and mannitol and stir for 15 min under the same conditions. After cooling, add the re...

technical field

[0001] The invention relates to the field of medicine, in particular to a hydroxypropyl-β-cyclodextrin hemostatic gauze and a preparation method thereof. Background technique

[0002] With the continuous progress of medical technology, new medical materials and related technologies have been well developed. Among them, the development and improvement of hemostatic materials are beneficial to improve the problems of bleeding and bleeding during surgery, which is of great significance and has become a hot research topic in the field of medicine. Traditional hemostatic gauze is generally made of cotton, linen, etc., which has problems such as poor antibacterial and bacteriostatic ability, gauze fibers easily lead to foreign body rejection, affecting wound healing, and easy adhesion to wound tissue during use, causing secondary damage. The generated waste has a complicated treatment process and is easy to pollute the environment.

[0003] Soluble hemostatic gau...

Examples

Embodiment Construction

[0020] Non-limiting examples of the present invention are as follows:

[0021] A hydroxypropyl-β-cyclodextrin hemostatic gauze is prepared from the following weight (kg) components:

[0022] Luffa leaf 4, Arborvitae leaf 1.5, Draconis 1.5, Snakeberry 1.5, Pine pollen 0.8, Hydroxypropyl-β-cyclodextrin 7, Gelatin 7, Sodium alginate 4, Polysorbate-80 0.15, Caprylic acid Glycerides 0.8, sodium carboxymethyl cellulose 3, excipients 1.5, water 200;

[0023] Among them, the auxiliary materials are made from the following weight (kg) raw materials:

[0024] Soy Lecithin 0.8, Glycerin 3, Macrogol 1.5, Bletilla striata Ultrafine Powder 1.5, Mannitol 3, Chlorhexidine Gluconate 1.5, Vitamin C 1.5, Water 18;

[0025] Preparation method of excipients:

[0026] Add soybean lecithin into water at 60°C and stir at 1000 r / min for 1 h, then add glycerin, polyethylene glycol, Bletilla striata superfine powder and mannitol and stir for 15 min under the same conditions. After cooling, add the re...