Preparation method and application of kidney-tonifying composition

Abstract

The invention discloses a preparation method and application of a kidney-tonifying composition, and relates to the technical field of traditional Chinese medicine kidney-tonifying compositions.The kidney-tonifying composition is prepared from, by mass, 20-30 parts of raw material agents, 10-15 parts of flavor enhancers, 5-8 parts of qi tonifying agents and 2-4 parts of auxiliary agents. The adjuvant is prepared from the following materials in parts by mass: 10-15 parts of liquorice, 5-8 parts of white granulated sugar, 20-40 parts of lalang grass rhizome and 20-30 parts of honeysuckle. The kidney-tonifying composition is small in dosage, good in compliance, convenient to carry and capable of effectively improving the medicine treatment effect of the kidney-yin deficiency effect on the kidney-yin deficiency disease; the composition can effectively improve rat body mass reduction caused by the kidney yin deficiency syndrome, can play roles in consolidating the foundation and nourishing yin by improving the serum hormone level of a rat model with the kidney yin deficiency syndrome, and can remarkably improve the kidney yin deficiency symptom.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine kidney-tonifying compositions, and in particular to a preparation method and application of the kidney-tonifying composition. Background Art

[0002] Aging is a systemic, gradual degeneration process in morphology, structure and physiological function of organisms as they age. It is a stage that biological individuals must go through. Aging individuals show a series of symptoms such as slow movement, slow reaction, decreased learning and memory ability, and organ function decline. "Suwen Jinkui Zhenlunyu" mentioned that "Husband's essence is the root of life." The essence stored in the kidney includes "innate essence" and "acquired essence". "Innate essence" is inherited from the reproductive essence of parents. It is innate and is the original substance that constitutes embryonic development. "Acquired essence" refers to the essence of water and grain generated by the spleen and stomach after the food ingested by people is born, as well as the remaining part of the essence generated in the physiological activities of the internal organs after metabolic balance, which is stored in the kidney. Traditional Chinese medicine believes that the kidney is the "innate foundation" and "the root of life". People with kidney deficiency or premature decline of kidney qi may show endocrine dysfunction, low immune function, and may affect the physiological functions of other internal organs, leading to premature aging.

[0003] Guben Yanling Pills are large honey pills, and the preparation process is to grind all the medicinal materials and add refined honey to make pills. The method of taking is chewing, which is not only large in quantity but also has a bad taste; it is inconvenient for patients to comply with and carry. At the same time, there are few experimental studies on the anti-aging of Guben Yanling Pills, and its application in the prevention and treatment of kidney yin deficiency has yet to be developed; in view of this, we propose a preparation method and application of a kidney-tonifying composition. Summary of the invention

[0004] In view of the deficiencies of the prior art, the present invention provides a preparation method of a kidney-tonifying composition and its application to solve the problems raised in the above background technology.

[0005] To achieve the above objectives, the present invention is implemented by the following technical scheme: a kidney-tonifying composition, wherein the kidney-tonifying composition is made of the following materials in proportion by weight:

[0006] 20-30 parts of raw material agent, 10-15 parts of flavor enhancer, 5-8 parts of qi replenisher, 2-4 parts of auxiliary agent;

[0007] The raw material agent is made of the following materials in proportion by mass: 40-60 parts of Ophiopogon japonicus, 50-70 parts of Schisandra chinensis, 50-70 parts of Asparagus cochinchinensis, 60-80 parts of Rehmannia glutinosa, 50-60 parts of Rehmannia glutinosa, 30-60 parts of Alisma orientalis, 30-60 parts of Poria cocos, 30-60 parts of Achyranthes bidentata, 50-60 parts of Cornus officinalis, 50-60 parts of Eucommia ulmoides, 30-60 parts of Lycium barbarum, 100-120 parts of Salvia miltiorrhiza, 50-60 parts of Lycium barbarum, and 30-60 parts of Rubus idaeus.

[0008] The flavor enhancer is made of the following materials in proportion by weight: 50-60 parts of costusroot, 20-30 parts of polygala, 60-80 parts of pine nuts, 50-60 parts of yam, and 20-30 parts of prickly ash;

[0009] The Qi-replenishing agent is made of the following materials in proportion by weight: 60-80 parts of Morinda officinalis, 20-30 parts of Acorus calamus, 100-120 parts of Cistanche deserticola, 40-60 parts of Ginseng, 30-60 parts of Deer Horn Glue, 100-120 parts of Cuscuta australis, 30-60 parts of Fish Bladder Pearls, and 10-15 parts of Pearls;

[0010] The auxiliary agent is made of the following materials in proportion by weight: 10-15 parts of licorice, 5-8 parts of white sugar, 20-40 parts of Imperata root, and 20-30 parts of honeysuckle.

[0011] The present invention also provides a method for preparing a kidney-tonifying composition, which comprises the following steps:

[0012] Step S1, grinding the pearls into fine powder and filtering the ground pearl powder; mixing licorice, white sugar, Imperata root and honeysuckle and grinding them;

[0013] Step S2, ginseng, antler glue, fish maw beads, and dodder seeds are mixed and crushed into fine powder, and the crushed mixed powder is sieved and filtered;

[0014] Step S3, decocting the remaining 22 medicinal materials except pearl, ginseng, deer antler glue, dodder seed, fish maw pearl and auxiliary medicinal materials to prepare an extract;

[0015] Step S4, mixing the fine powder extracts of pearl, ginseng, antler glue, dodder seed, and fish bladder pearl with auxiliary medicinal materials to prepare a kidney-tonifying composition, and performing a mixing and drying process on the kidney-tonifying composition, and storing and sorting the treated kidney-tonifying composition.

[0016] Optionally, in step S1, the pearls are crushed separately according to the raw material characteristics and passed through a 80-100 mesh sieve;

[0017] Optionally, in step S2, according to the raw material characteristics, ginseng, deer antler glue, fish maw beads, and dog whip are mixed and crushed, and passed through a 80-100 mesh sieve;

[0018] Optionally, the remaining 22 medicinal materials described in step S3 are Radix Ophiopogonis, Fructus Schisandrae Chinensis, Asparagus Codonopsis, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Alismatis, Poria, Achyranthes Bidentatae, Fructus Corni, Eucommia Bark, Cortex Lycii, Salvia Miltiorrhizae, Fructus Lycii, Rubus Idaeus, Radix Aucklandiae, Radix Polygalae, Semen Platycladi, Dioscorea Oppositae, Zanthoxylum bungeanum, Morinda Officinalis, Acorus Calamus, and Cistanche Deserticola;

[0019] Optionally, the extract preparation method described in step S3 is to add 8 to 12 times the weight of water to the 22 mixed medicinal materials, decoct and extract for 2 to 3 times, each time for 1.5 to 2 hours, combine the decoctions, concentrate the filtrate under reduced pressure, and dry under reduced pressure to prepare the extract;

[0020] Optionally, the dosage form of the kidney-tonifying composition in step S4 includes pills, granules, tablets and capsules.

[0021] The present invention also provides an application of a kidney-tonifying composition, wherein the kidney-tonifying composition is used for preparing a medicine for treating kidney-yin deficiency.

[0022] The invention provides a use of a kidney-tonifying composition for preparing a medicine for treating kidney-yin deficiency.

[0023] Compared with the prior art, the present invention proposes a kidney-tonifying composition with the following beneficial effects:

[0024] The proposed kidney-tonifying composition has a small dosage, good compliance, and is easy to carry, and can effectively improve the drug treatment effect of the kidney yin deficiency composition on kidney yin deficiency symptoms; the composition can effectively improve the weight loss of rats caused by kidney yin deficiency syndrome, and can play a role in strengthening the body and nourishing yin by improving the serum hormone level of the kidney yin deficiency syndrome rat model. The composition can significantly improve the symptoms of kidney yin deficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the preparation method of the present invention. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] Embodiment 1:

[0028] A kidney-tonifying composition, which is made from the following materials in proportion by weight:

[0029] 20-25 parts of raw material agent, 10-12 parts of flavor enhancer, 5-7 parts of qi replenisher, 2-3 parts of auxiliary agent;

[0030] The raw material preparation is made by the following materials in proportion by mass: 40-60 parts of Ophiopogon japonicus, 50-70 parts of Schisandra chinensis, 50-70 parts of Asparagus cochinchinensis, 60-80 parts of Rehmannia glutinosa, 50-60 parts of Rehmannia glutinosa, 30-60 parts of Alisma orientalis, 30-60 parts of Poria cocos, 30-60 parts of Achyranthes bidentata, 50-60 parts of Cornus officinalis, 50-60 parts of Eucommia ulmoides, 30-60 parts of Lycium barbarum, 100-120 parts of Salvia miltiorrhiza, 50-60 parts of Lycium barbarum, and 30-60 parts of Rubus idaeus.

[0031] The flavor enhancer is made of the following materials in proportion by weight: 50-60 parts of costusroot, 20-30 parts of polygala, 60-80 parts of pine nuts, 50-60 parts of yam, and 20-30 parts of prickly ash;

[0032] The Qi-replenishing agent is made of the following materials in proportion by weight: 60-80 parts of Morinda officinalis, 20-30 parts of Acorus calamus, 100-120 parts of Cistanche deserticola, 40-60 parts of Ginseng, 30-60 parts of Deer Horn Glue, 100-120 parts of Cuscuta australis, 30-60 parts of Fish Bladder Pearls, and 10-15 parts of Pearls;

[0033] The auxiliary agent is made of the following materials in proportion by weight: 10-15 parts of licorice, 5-8 parts of white sugar, 20-40 parts of Imperata root and 20-30 parts of honeysuckle.

[0034] In this embodiment, the preparation method of the kidney-tonifying composition comprises the following steps:

[0035] Step S1, grinding the pearls into fine powder and filtering the ground pearl powder; mixing licorice, white sugar, Imperata root and honeysuckle and blending them, crushing the pearls separately according to the characteristics of the raw materials and passing through an 80-90 mesh sieve;

[0036] Step S2, ginseng, antler glue, fish bladder beads, and dodder seeds are mixed and crushed into fine powder, and the crushed mixed powder is sieved and filtered. According to the characteristics of the raw materials, ginseng, antler glue, fish bladder beads, and dog whip are mixed and crushed, and passed through an 80-90 mesh sieve;

[0037] Step S3, except pearl, ginseng, antler glue, dodder seed, fish maw pearl and auxiliary medicinal materials, the remaining 22 medicinal materials are combined and decocted to prepare an extract, and the remaining 22 medicinal materials are ophiopogon japonicus, schisandra chinensis, asparagus cochinchinensis, rehmannia root, prepared rehmannia root, oriental rhizome, tuckahoe, cyathula, cornus officinalis, eucommia bark, salvia miltiorrhiza, wolfberry, raspberry, costus root, polygala tenuifolia, cypress seed, yam, zanthoxylum bungeanum, morinda officinalis, calamus calamus and cistanche deserticola;

[0038] The extract preparation method comprises the following steps: adding 8 to 12 times the weight of water to the 22 mixed medicinal materials, decocting and extracting for 2 to 3 times, each time for 1.5 to 2 hours, combining the decoctions, concentrating the filtrate under reduced pressure, and drying under reduced pressure to obtain the extract;

[0039] Step S4, mixing the fine powder extracts of pearl, ginseng, deer antler glue, dodder seed, and fish maw pearl with auxiliary medicinal materials to prepare a kidney-tonifying composition, and performing a mixing and drying treatment on the kidney-tonifying composition, and storing and sorting the treated kidney-tonifying composition; wherein the kidney-tonifying composition dosage forms include pills, granules, tablets, and capsules.

[0040] This embodiment also proposes an application of a kidney-tonifying composition, which is used for preparing a drug for treating kidney-yin deficiency.

[0041] Embodiment 2:

[0042] A kidney-tonifying composition, which is made from the following materials in proportion by weight:

[0043] 25-30 parts of raw material agent, 12-15 parts of flavor enhancer, 7-8 parts of qi replenisher, 3-4 parts of auxiliary agent;

[0044] The raw material preparation is made by the following materials in proportion by mass: 40-60 parts of Ophiopogon japonicus, 50-70 parts of Schisandra chinensis, 50-70 parts of Asparagus cochinchinensis, 60-80 parts of Rehmannia glutinosa, 50-60 parts of Rehmannia glutinosa, 30-60 parts of Alisma orientalis, 30-60 parts of Poria cocos, 30-60 parts of Achyranthes bidentata, 50-60 parts of Cornus officinalis, 50-60 parts of Eucommia ulmoides, 30-60 parts of Lycium barbarum, 100-120 parts of Salvia miltiorrhiza, 50-60 parts of Lycium barbarum, and 30-60 parts of Rubus idaeus.

[0045] The flavor enhancer is made of the following materials in proportion by weight: 50-60 parts of costusroot, 20-30 parts of polygala, 60-80 parts of pine nuts, 50-60 parts of yam, and 20-30 parts of prickly ash;

[0046] The Qi-replenishing agent is made of the following materials in proportion by weight: 60-80 parts of Morinda officinalis, 20-30 parts of Acorus calamus, 100-120 parts of Cistanche deserticola, 40-60 parts of Ginseng, 30-60 parts of Deer Horn Glue, 100-120 parts of Cuscuta australis, 30-60 parts of Fish Bladder Pearls, and 10-15 parts of Pearls;

[0047] The auxiliary agent is made of the following materials in proportion by weight: 10-15 parts of licorice, 5-8 parts of white sugar, 20-40 parts of Imperata root and 20-30 parts of honeysuckle.

[0048] In this embodiment, the preparation method of the kidney-tonifying composition comprises the following steps:

[0049] Step S1, grinding the pearls into fine powder and filtering the ground pearl powder; mixing licorice, white sugar, Imperata root and honeysuckle and blending them, crushing the pearls separately according to the characteristics of the raw materials, and passing through a 90-100 mesh sieve;

[0050] Step S2, ginseng, antler glue, fish bladder beads, and dodder seeds are mixed and crushed into fine powder, and the crushed mixed powder is sieved and filtered. According to the characteristics of the raw materials, ginseng, antler glue, fish bladder beads, and dog whip are mixed and crushed, and passed through a 90-100 mesh sieve;

[0051] Step S3, except pearl, ginseng, antler glue, dodder seed, fish maw pearl and auxiliary medicinal materials, the remaining 22 medicinal materials are combined and decocted to prepare an extract, and the remaining 22 medicinal materials are ophiopogon japonicus, schisandra chinensis, asparagus cochinchinensis, rehmannia root, prepared rehmannia root, oriental rhizome, tuckahoe, cyathula, cornus officinalis, eucommia bark, salvia miltiorrhiza, wolfberry, raspberry, costus root, polygala tenuifolia, cypress seed, yam, zanthoxylum bungeanum, morinda officinalis, calamus calamus and cistanche deserticola;

[0052] The extract preparation method comprises the following steps: adding 8 to 12 times the weight of water to the 22 mixed medicinal materials, decocting and extracting for 2 to 3 times, each time for 1.5 to 2 hours, combining the decoctions, concentrating the filtrate under reduced pressure, and drying under reduced pressure to obtain the extract;

[0053] Step S4, mixing the fine powder extracts of pearl, ginseng, deer antler glue, dodder seed, and fish maw pearl with auxiliary medicinal materials to prepare a kidney-tonifying composition, and performing a mixing and drying treatment on the kidney-tonifying composition, and storing and sorting the treated kidney-tonifying composition; wherein the kidney-tonifying composition dosage forms include pills, granules, tablets, and capsules.

[0054] As an application of this embodiment: the kidney-tonifying composition has a small dosage, good compliance, and is easy to carry, and can effectively enhance the drug treatment effect of the kidney yin deficiency composition on kidney yin deficiency symptoms; the composition can effectively improve the weight loss of rats caused by kidney yin deficiency, and can play a role in strengthening the body and nourishing yin by improving the serum hormone levels of the kidney yin deficiency rat model, and the composition can significantly improve the symptoms of kidney yin deficiency.

[0055] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A kidney-tonifying composition, characterized in that: The kidney-tonifying composition is made of the following materials in proportion by mass: 20-30 parts of raw material agent, 10-15 parts of flavor enhancer, 5-8 parts of qi replenisher, 2-4 parts of auxiliary agent; The raw material agent is made of the following materials in proportion by mass: 40-60 parts of Ophiopogon japonicus, 50-70 parts of Schisandra chinensis, 50-70 parts of Asparagus cochinchinensis, 60-80 parts of Rehmannia glutinosa, 50-60 parts of Rehmannia glutinosa, 30-60 parts of Alisma orientalis, 30-60 parts of Poria cocos, 30-60 parts of Achyranthes bidentata, 50-60 parts of Cornus officinalis, 50-60 parts of Eucommia ulmoides, 30-60 parts of Lycium barbarum, 100-120 parts of Salvia miltiorrhiza, 50-60 parts of Lycium barbarum, and 30-60 parts of Rubus idaeus. The flavor enhancer is made of the following materials in proportion by weight: 50-60 parts of costusroot, 20-30 parts of polygala, 60-80 parts of pine nuts, 50-60 parts of yam, and 20-30 parts of prickly ash; The Qi-replenishing agent is made of the following materials in proportion by weight: 60-80 parts of Morinda officinalis, 20-30 parts of Acorus calamus, 100-120 parts of Cistanche deserticola, 40-60 parts of Ginseng, 30-60 parts of Deer Horn Glue, 100-120 parts of Cuscuta australis, 30-60 parts of Fish Bladder Pearls, and 10-15 parts of Pearls; The auxiliary agent is made of the following materials in proportion by weight: 10-15 parts of licorice, 5-8 parts of white sugar, 20-40 parts of Imperata root, and 20-30 parts of honeysuckle.

2. A method for preparing a kidney-tonifying composition according to claim 1, comprising the following steps: Step S1, grinding the pearls into fine powder and filtering the ground pearl powder; mixing licorice, white sugar, Imperata root and honeysuckle and grinding them; Step S2, ginseng, antler glue, fish maw beads, and dodder seeds are mixed and crushed into fine powder, and the crushed mixed powder is sieved and filtered; Step S3, decocting the remaining 22 medicinal materials except pearl, ginseng, deer antler glue, dodder seed, fish maw pearl and auxiliary medicinal materials to prepare an extract; Step S4, mixing the fine powder extracts of pearl, ginseng, antler glue, dodder seed, and fish bladder pearl with auxiliary medicinal materials to prepare a kidney-tonifying composition, and performing a mixing and drying process on the kidney-tonifying composition, and storing and sorting the treated kidney-tonifying composition.

3. The method for preparing the kidney-tonifying composition according to claim 2, characterized in that: In step S1, the pearls are crushed separately according to the characteristics of the raw materials and passed through a 80-100 mesh sieve.

4. The method for preparing the kidney-tonifying composition according to claim 2, characterized in that: In step S2, according to the raw material characteristics, ginseng, deer antler glue, fish maw beads and dog whip are mixed and crushed, and passed through a 80-100 mesh sieve.

5. The method for preparing the kidney-tonifying composition according to claim 2, characterized in that: The remaining 22 medicinal materials described in step S3 are Ophiopogon japonicus, Schisandra chinensis, Asparagus cochinchinensis, Rehmannia glutinosa, Rehmannia glutinosa, Alisma orientalis, Poria cocos, Achyranthes bidentata, Cornus officinalis, Eucommia ulmoides, Lycium bark, Salvia miltiorrhiza, Lycium barbarum, Rubus idaeus, Costus root, Polygala tenuifolia, Semen cypress, Dioscorea batatas, Zanthoxylum bungeanum, Morinda officinalis, Acorus calamus, and Cistanche deserticola.

6. The method for preparing the kidney-tonifying composition according to claim 2, characterized in that: The extract preparation method described in step S3 is as follows: 8 to 12 times the weight of 22 mixed medicinal materials are added with water, and the mixture is decocted and extracted 2 to 3 times, each time for 1.5 to 2 hours, the decoctions are combined, and the filtrate is concentrated under reduced pressure and dried under reduced pressure to obtain the extract.

7. The method for preparing the kidney-tonifying composition according to claim 2, characterized in that: The dosage forms of the kidney-tonifying composition in step S4 include pills, granules, tablets and capsules.

8. The use of the kidney-tonifying composition according to any one of claims 1 to 7, characterized in that: The kidney-tonifying composition is used for preparing medicine for treating kidney-yin deficiency.

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